Rationale, design, and method of the Diabetes & Women's Health study – a study of long-term health implications of glucose intolerance in pregnancy and their determinants
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Rationale, design, and method of the Diabetes & Women's Health study – a study of long-term health implications of glucose intolerance in pregnancy and their determinants. / Zhang, Cuilin; Hu, Frank B; Olsen, Sjurdur F; Vaag, Allan; Gore-Langton, Robert; Chavarro, Jorge E; Bao, Wei; Yeung, Edwina; Bowers, Katherine; Grunnet, Louise G; Sherman, Seth; Kiely, Michele; Strøm, Marin; Hansen, Susanne; Liu, Aiyi; Mills, James; Fan, Ruzong; DWH study team.
In: Acta Obstetricia et Gynecologica Scandinavica, Vol. 93, No. 11, 11.2014, p. 1123-1130.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - Rationale, design, and method of the Diabetes & Women's Health study – a study of long-term health implications of glucose intolerance in pregnancy and their determinants
AU - Zhang, Cuilin
AU - Hu, Frank B
AU - Olsen, Sjurdur F
AU - Vaag, Allan
AU - Gore-Langton, Robert
AU - Chavarro, Jorge E
AU - Bao, Wei
AU - Yeung, Edwina
AU - Bowers, Katherine
AU - Grunnet, Louise G
AU - Sherman, Seth
AU - Kiely, Michele
AU - Strøm, Marin
AU - Hansen, Susanne
AU - Liu, Aiyi
AU - Mills, James
AU - Fan, Ruzong
AU - DWH study team
N1 - © 2014 Nordic Federation of Societies of Obstetrics and Gynecology.
PY - 2014/11
Y1 - 2014/11
N2 - Women who develop gestational diabetes mellitus or impaired glucose tolerance during pregnancy are at substantially increased risk for type 2 diabetes and comorbidities after pregnancy. Little is known about the role of genetic factors and their interactions with environmental factors in determining the transition from gestational diabetes mellitus to overt type 2 diabetes mellitus. These critical data gaps served as the impetus for this Diabetes & Women's Health study with the overall goal of investigating genetic factors and their interactions with risk factors amenable to clinical or public health interventions in relation to the transition of gestational diabetes mellitus to type 2 diabetes mellitus. To achieve the goal efficiently, we are applying a hybrid design enrolling and collecting data longitudinally from approximately 4000 women with a medical history of gestational diabetes mellitus in two existing prospective cohorts, the Nurses' Health Study II and the Danish National Birth Cohort. Women who had a medical history of gestational diabetes mellitus in one or more of their pregnancies are eligible for the present study. After enrollment, we follow study participants for an additional 2 years to collect updated information on major clinical and environmental factors that may predict type 2 diabetes mellitus risk as well as with biospecimens to measure genetic and biochemical markers implicated in glucose metabolism. Newly collected data will be appended to the relevant existing data for the creation of a new database inclusive of genetic, epigenetic and environmental data. Findings from the study are critical for the development of targeted and more effective strategies to prevent type 2 diabetes mellitus and its complications in this high-risk population.
AB - Women who develop gestational diabetes mellitus or impaired glucose tolerance during pregnancy are at substantially increased risk for type 2 diabetes and comorbidities after pregnancy. Little is known about the role of genetic factors and their interactions with environmental factors in determining the transition from gestational diabetes mellitus to overt type 2 diabetes mellitus. These critical data gaps served as the impetus for this Diabetes & Women's Health study with the overall goal of investigating genetic factors and their interactions with risk factors amenable to clinical or public health interventions in relation to the transition of gestational diabetes mellitus to type 2 diabetes mellitus. To achieve the goal efficiently, we are applying a hybrid design enrolling and collecting data longitudinally from approximately 4000 women with a medical history of gestational diabetes mellitus in two existing prospective cohorts, the Nurses' Health Study II and the Danish National Birth Cohort. Women who had a medical history of gestational diabetes mellitus in one or more of their pregnancies are eligible for the present study. After enrollment, we follow study participants for an additional 2 years to collect updated information on major clinical and environmental factors that may predict type 2 diabetes mellitus risk as well as with biospecimens to measure genetic and biochemical markers implicated in glucose metabolism. Newly collected data will be appended to the relevant existing data for the creation of a new database inclusive of genetic, epigenetic and environmental data. Findings from the study are critical for the development of targeted and more effective strategies to prevent type 2 diabetes mellitus and its complications in this high-risk population.
KW - Adult
KW - Diabetes Mellitus, Type 2
KW - Diabetes, Gestational
KW - Female
KW - Gene-Environment Interaction
KW - Genetic Predisposition to Disease
KW - Glucose Intolerance
KW - Glucose Tolerance Test
KW - Humans
KW - Nurses
KW - Pregnancy
KW - Pregnancy Complications
KW - Prospective Studies
KW - Questionnaires
KW - Research Design
KW - Risk Factors
KW - United States
U2 - 10.1111/aogs.12425
DO - 10.1111/aogs.12425
M3 - Journal article
C2 - 24828694
VL - 93
SP - 1123
EP - 1130
JO - Acta Obstetricia et Gynecologica Scandinavica
JF - Acta Obstetricia et Gynecologica Scandinavica
SN - 0001-6349
IS - 11
ER -
ID: 138382535