Rax: Developmental and Daily Expression Patterns in the Rat Pineal Gland and Retina

Research output: Contribution to journalJournal articleResearchpeer-review

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Rax: Developmental and Daily Expression Patterns in the Rat Pineal Gland and Retina. / Rohde, Kristian; Klein, David C; Møller, Morten; Rath, Martin F.

In: Journal of Neurochemistry, Vol. 118, No. 6, 2011, p. 999-1007.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Rohde, K, Klein, DC, Møller, M & Rath, MF 2011, 'Rax: Developmental and Daily Expression Patterns in the Rat Pineal Gland and Retina', Journal of Neurochemistry, vol. 118, no. 6, pp. 999-1007. https://doi.org/10.1111/j.1471-4159.2011.07385.x

APA

Rohde, K., Klein, D. C., Møller, M., & Rath, M. F. (2011). Rax: Developmental and Daily Expression Patterns in the Rat Pineal Gland and Retina. Journal of Neurochemistry, 118(6), 999-1007. https://doi.org/10.1111/j.1471-4159.2011.07385.x

Vancouver

Rohde K, Klein DC, Møller M, Rath MF. Rax: Developmental and Daily Expression Patterns in the Rat Pineal Gland and Retina. Journal of Neurochemistry. 2011;118(6):999-1007. https://doi.org/10.1111/j.1471-4159.2011.07385.x

Author

Rohde, Kristian ; Klein, David C ; Møller, Morten ; Rath, Martin F. / Rax: Developmental and Daily Expression Patterns in the Rat Pineal Gland and Retina. In: Journal of Neurochemistry. 2011 ; Vol. 118, No. 6. pp. 999-1007.

Bibtex

@article{197941b23d1d40a389213b2a3593b732,
title = "Rax: Developmental and Daily Expression Patterns in the Rat Pineal Gland and Retina",
abstract = "Retina and anterior neural fold homeobox (Rax) gene encodes a transcription factor essential for vertebrate eye development. Recent microarray studies indicate that Rax is expressed in the adult rat pineal gland and retina. The present study reveals that Rax expression levels in the rat change significantly during retinal development with a peak occurring at embryonic day (E) 18, whereas Rax expression in the pineal is relatively delayed and not detectable until E20. In both tissues, Rax is expressed throughout postnatal development into adulthood. In the mature rat pineal gland, the abundance of Rax transcripts increases 2-fold during the light period with a peak occurring at dusk. These findings are consistent with the evidence that Rax is of functional importance in eye development and suggest a role of Rax in the developing pineal gland. In addition, it would appear possible that Rax contributes to phenotype maintenance in the mature retina and pineal gland and may facilitate 24-h changes in the pineal transcriptome.",
keywords = "Faculty of Health and Medical Sciences, circadian rhythm, retina, gene expression",
author = "Kristian Rohde and Klein, {David C} and Morten M{\o}ller and Rath, {Martin F}",
note = "Journal of Neurochemistry {\circledC} 2011 International Society for Neurochemistry.",
year = "2011",
doi = "10.1111/j.1471-4159.2011.07385.x",
language = "English",
volume = "118",
pages = "999--1007",
journal = "Journal of Neurochemistry",
issn = "0022-3042",
publisher = "Wiley-Blackwell",
number = "6",

}

RIS

TY - JOUR

T1 - Rax: Developmental and Daily Expression Patterns in the Rat Pineal Gland and Retina

AU - Rohde, Kristian

AU - Klein, David C

AU - Møller, Morten

AU - Rath, Martin F

N1 - Journal of Neurochemistry © 2011 International Society for Neurochemistry.

PY - 2011

Y1 - 2011

N2 - Retina and anterior neural fold homeobox (Rax) gene encodes a transcription factor essential for vertebrate eye development. Recent microarray studies indicate that Rax is expressed in the adult rat pineal gland and retina. The present study reveals that Rax expression levels in the rat change significantly during retinal development with a peak occurring at embryonic day (E) 18, whereas Rax expression in the pineal is relatively delayed and not detectable until E20. In both tissues, Rax is expressed throughout postnatal development into adulthood. In the mature rat pineal gland, the abundance of Rax transcripts increases 2-fold during the light period with a peak occurring at dusk. These findings are consistent with the evidence that Rax is of functional importance in eye development and suggest a role of Rax in the developing pineal gland. In addition, it would appear possible that Rax contributes to phenotype maintenance in the mature retina and pineal gland and may facilitate 24-h changes in the pineal transcriptome.

AB - Retina and anterior neural fold homeobox (Rax) gene encodes a transcription factor essential for vertebrate eye development. Recent microarray studies indicate that Rax is expressed in the adult rat pineal gland and retina. The present study reveals that Rax expression levels in the rat change significantly during retinal development with a peak occurring at embryonic day (E) 18, whereas Rax expression in the pineal is relatively delayed and not detectable until E20. In both tissues, Rax is expressed throughout postnatal development into adulthood. In the mature rat pineal gland, the abundance of Rax transcripts increases 2-fold during the light period with a peak occurring at dusk. These findings are consistent with the evidence that Rax is of functional importance in eye development and suggest a role of Rax in the developing pineal gland. In addition, it would appear possible that Rax contributes to phenotype maintenance in the mature retina and pineal gland and may facilitate 24-h changes in the pineal transcriptome.

KW - Faculty of Health and Medical Sciences

KW - circadian rhythm, retina, gene expression

U2 - 10.1111/j.1471-4159.2011.07385.x

DO - 10.1111/j.1471-4159.2011.07385.x

M3 - Journal article

C2 - 21749377

VL - 118

SP - 999

EP - 1007

JO - Journal of Neurochemistry

JF - Journal of Neurochemistry

SN - 0022-3042

IS - 6

ER -

ID: 33855232