Relationship of frontal D2/3 binding potentials to cognition: a study of antipsychotic-naive schizophrenia patients

Research output: Contribution to journalJournal articlepeer-review

Standard

Relationship of frontal D2/3 binding potentials to cognition : a study of antipsychotic-naive schizophrenia patients. / Fagerlund, Birgitte; Pinborg, Lars H; Mortensen, Erik Lykke; Friberg, Lars; Baaré, William F C; Gade, Anders; Svarer, Claus; Glenthøj, Birte Y.

In: International Journal of Neuropsychopharmacology, Vol. 16, No. 1, 2013, p. 23-36.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Fagerlund, B, Pinborg, LH, Mortensen, EL, Friberg, L, Baaré, WFC, Gade, A, Svarer, C & Glenthøj, BY 2013, 'Relationship of frontal D2/3 binding potentials to cognition: a study of antipsychotic-naive schizophrenia patients', International Journal of Neuropsychopharmacology, vol. 16, no. 1, pp. 23-36. https://doi.org/10.1017/S146114571200003X

APA

Fagerlund, B., Pinborg, L. H., Mortensen, E. L., Friberg, L., Baaré, W. F. C., Gade, A., Svarer, C., & Glenthøj, B. Y. (2013). Relationship of frontal D2/3 binding potentials to cognition: a study of antipsychotic-naive schizophrenia patients. International Journal of Neuropsychopharmacology, 16(1), 23-36. https://doi.org/10.1017/S146114571200003X

Vancouver

Fagerlund B, Pinborg LH, Mortensen EL, Friberg L, Baaré WFC, Gade A et al. Relationship of frontal D2/3 binding potentials to cognition: a study of antipsychotic-naive schizophrenia patients. International Journal of Neuropsychopharmacology. 2013;16(1):23-36. https://doi.org/10.1017/S146114571200003X

Author

Fagerlund, Birgitte ; Pinborg, Lars H ; Mortensen, Erik Lykke ; Friberg, Lars ; Baaré, William F C ; Gade, Anders ; Svarer, Claus ; Glenthøj, Birte Y. / Relationship of frontal D2/3 binding potentials to cognition : a study of antipsychotic-naive schizophrenia patients. In: International Journal of Neuropsychopharmacology. 2013 ; Vol. 16, No. 1. pp. 23-36.

Bibtex

@article{1cf80061f1114667843d7aa6bbaad5aa,
title = "Relationship of frontal D2/3 binding potentials to cognition: a study of antipsychotic-naive schizophrenia patients",
abstract = "Studies of in vivo dopamine receptors in schizophrenia have mostly focused on D2 receptors in striatal areas or on D1 receptors in cortex. No previous study has examined the correlation between cortical dopamine D2/3 receptor binding potentials and cognition in schizophrenia patients. The objective was to examine this relation in the frontal cortex in first-episode, drug-naive schizophrenia patients. Based on preclinical and pharmacological evidence, we specifically expected to find a relation between D2/3 receptor binding potentials and set shifting. This was a cross-sectional, case-control study using single-photon emission computerized tomography with the D2/3-receptor ligand [123I]epidepride, co-registered with structural magnetic resonance imaging and correlated to cognitive measures. Participants were 24 antipsychotic-naive, first-episode schizophrenia patients and 20 healthy controls matched for gender and age. For patients, a significant linear correlation between D2/3 BPND and set shifting was found, while significant quadratic associations were observed for verbal fluency, planning and attention. For controls, the only significant association with D2/3 BPND was a quadratic partial correlation for set shifting. The main findings indicated a relation between D2/3 receptor binding in the frontal cortex and set shifting, planning and attention, but also support a differential involvement of cortical dopamine D2/3 receptor binding in at least some cognitive functions, perhaps particularly attention, in schizophrenia patients compared to healthy people. The results suggest that cortical D2/3 receptor function may be more involved in some cognitive functions (i.e. attention, fluency and planning) in patients with schizophrenia than in healthy people, suggesting that information processing in schizophrenia may be characterized by lower signal:noise ratios.",
author = "Birgitte Fagerlund and Pinborg, {Lars H} and Mortensen, {Erik Lykke} and Lars Friberg and Baar{\'e}, {William F C} and Anders Gade and Claus Svarer and Glenth{\o}j, {Birte Y}",
year = "2013",
doi = "10.1017/S146114571200003X",
language = "English",
volume = "16",
pages = "23--36",
journal = "International Journal of Neuropsychopharmacology",
issn = "1461-1457",
publisher = "Oxford University Press",
number = "1",

}

RIS

TY - JOUR

T1 - Relationship of frontal D2/3 binding potentials to cognition

T2 - a study of antipsychotic-naive schizophrenia patients

AU - Fagerlund, Birgitte

AU - Pinborg, Lars H

AU - Mortensen, Erik Lykke

AU - Friberg, Lars

AU - Baaré, William F C

AU - Gade, Anders

AU - Svarer, Claus

AU - Glenthøj, Birte Y

PY - 2013

Y1 - 2013

N2 - Studies of in vivo dopamine receptors in schizophrenia have mostly focused on D2 receptors in striatal areas or on D1 receptors in cortex. No previous study has examined the correlation between cortical dopamine D2/3 receptor binding potentials and cognition in schizophrenia patients. The objective was to examine this relation in the frontal cortex in first-episode, drug-naive schizophrenia patients. Based on preclinical and pharmacological evidence, we specifically expected to find a relation between D2/3 receptor binding potentials and set shifting. This was a cross-sectional, case-control study using single-photon emission computerized tomography with the D2/3-receptor ligand [123I]epidepride, co-registered with structural magnetic resonance imaging and correlated to cognitive measures. Participants were 24 antipsychotic-naive, first-episode schizophrenia patients and 20 healthy controls matched for gender and age. For patients, a significant linear correlation between D2/3 BPND and set shifting was found, while significant quadratic associations were observed for verbal fluency, planning and attention. For controls, the only significant association with D2/3 BPND was a quadratic partial correlation for set shifting. The main findings indicated a relation between D2/3 receptor binding in the frontal cortex and set shifting, planning and attention, but also support a differential involvement of cortical dopamine D2/3 receptor binding in at least some cognitive functions, perhaps particularly attention, in schizophrenia patients compared to healthy people. The results suggest that cortical D2/3 receptor function may be more involved in some cognitive functions (i.e. attention, fluency and planning) in patients with schizophrenia than in healthy people, suggesting that information processing in schizophrenia may be characterized by lower signal:noise ratios.

AB - Studies of in vivo dopamine receptors in schizophrenia have mostly focused on D2 receptors in striatal areas or on D1 receptors in cortex. No previous study has examined the correlation between cortical dopamine D2/3 receptor binding potentials and cognition in schizophrenia patients. The objective was to examine this relation in the frontal cortex in first-episode, drug-naive schizophrenia patients. Based on preclinical and pharmacological evidence, we specifically expected to find a relation between D2/3 receptor binding potentials and set shifting. This was a cross-sectional, case-control study using single-photon emission computerized tomography with the D2/3-receptor ligand [123I]epidepride, co-registered with structural magnetic resonance imaging and correlated to cognitive measures. Participants were 24 antipsychotic-naive, first-episode schizophrenia patients and 20 healthy controls matched for gender and age. For patients, a significant linear correlation between D2/3 BPND and set shifting was found, while significant quadratic associations were observed for verbal fluency, planning and attention. For controls, the only significant association with D2/3 BPND was a quadratic partial correlation for set shifting. The main findings indicated a relation between D2/3 receptor binding in the frontal cortex and set shifting, planning and attention, but also support a differential involvement of cortical dopamine D2/3 receptor binding in at least some cognitive functions, perhaps particularly attention, in schizophrenia patients compared to healthy people. The results suggest that cortical D2/3 receptor function may be more involved in some cognitive functions (i.e. attention, fluency and planning) in patients with schizophrenia than in healthy people, suggesting that information processing in schizophrenia may be characterized by lower signal:noise ratios.

U2 - 10.1017/S146114571200003X

DO - 10.1017/S146114571200003X

M3 - Journal article

C2 - 22338593

VL - 16

SP - 23

EP - 36

JO - International Journal of Neuropsychopharmacology

JF - International Journal of Neuropsychopharmacology

SN - 1461-1457

IS - 1

ER -

ID: 122547971