The mechanistic target of rapamycin (mTOR) exerts both rapamycin-sensitive and rapamycin-insensitive signaling events, and the rapamycin-sensitive components of mTOR signaling have been widely implicated in the pathway through which resistance exercise induces skeletal muscle hypertrophy. This review explores the hypothesis that rapamycin-insensitive components of mTOR signaling also contribute to this highly important process.

Summary: This review examines whether both rapamycin-sensitive, and rapamycin-insensitive, components of mTOR signaling contribute to the hypertrophic effects of resistance exercise.