Risk of breast cancer in Danish women occupationally exposed to organic solvents, including ethanol
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Risk of breast cancer in Danish women occupationally exposed to organic solvents, including ethanol. / Pedersen, Julie Elbaek; Strandberg-Larsen, Katrine; Andersson, Michael; Hansen, Johnni.
In: American Journal of Industrial Medicine, Vol. 65, No. 8, 2022, p. 660-668.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Risk of breast cancer in Danish women occupationally exposed to organic solvents, including ethanol
AU - Pedersen, Julie Elbaek
AU - Strandberg-Larsen, Katrine
AU - Andersson, Michael
AU - Hansen, Johnni
N1 - Publisher Copyright: © 2022 Wiley Periodicals LLC.
PY - 2022
Y1 - 2022
N2 - Background: Organic solvents have been suggested to increase the risk of breast cancer although the epidemiologic evidence is limited. This study explored the association between organic solvents and breast cancer. Methods: This nested population-based case-control study comprised 845 women with primary breast cancer initially identified in the Danish Cancer Registry between 2000 and 2003, and 1500 controls matched on year of birth who were randomly selected from the Danish Civil Registration System. Information on occupational exposure to organic solvents, and specifically ethanol, as well as risk factors for breast cancer was collected through structured interviews. Results: For organic solvents, an increased risk was indicated for ever-exposure (odds ratio = 3.20, 95% confidence interval: 2.27–4.52), however, no noteworthy risk patterns were detected when exploring duration of exposure and cumulative exposure. Ever-exposure to organic solvents was associated with an increased risk of estrogen receptor negative and positive tumors as well as pre- and postmenopausal breast cancer. No associations were detected between occupational exposure to ethanol and breast cancer. Conclusions: This study indicates a positive association between organic solvents and breast cancer.
AB - Background: Organic solvents have been suggested to increase the risk of breast cancer although the epidemiologic evidence is limited. This study explored the association between organic solvents and breast cancer. Methods: This nested population-based case-control study comprised 845 women with primary breast cancer initially identified in the Danish Cancer Registry between 2000 and 2003, and 1500 controls matched on year of birth who were randomly selected from the Danish Civil Registration System. Information on occupational exposure to organic solvents, and specifically ethanol, as well as risk factors for breast cancer was collected through structured interviews. Results: For organic solvents, an increased risk was indicated for ever-exposure (odds ratio = 3.20, 95% confidence interval: 2.27–4.52), however, no noteworthy risk patterns were detected when exploring duration of exposure and cumulative exposure. Ever-exposure to organic solvents was associated with an increased risk of estrogen receptor negative and positive tumors as well as pre- and postmenopausal breast cancer. No associations were detected between occupational exposure to ethanol and breast cancer. Conclusions: This study indicates a positive association between organic solvents and breast cancer.
KW - breast cancer
KW - epidemiology
KW - occupational health
KW - organic solvents
KW - women
U2 - 10.1002/ajim.23397
DO - 10.1002/ajim.23397
M3 - Journal article
C2 - 35615993
AN - SCOPUS:85130593819
VL - 65
SP - 660
EP - 668
JO - American Journal of Industrial Medicine
JF - American Journal of Industrial Medicine
SN - 0271-3586
IS - 8
ER -
ID: 308755062