Role of oxidative damage in toxicity of particulates
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Role of oxidative damage in toxicity of particulates. / Møller, Peter; Jacobsen, Nicklas R; Folkmann, Janne K; Danielsen, Pernille H; Mikkelsen, Lone; Hemmingsen, Jette G; Vesterdal, Lise K; Forchhammer, Lykke; Wallin, Håkan; Loft, Steffen.
In: Free Radical Research, Vol. 44, No. 1, 2010, p. 1-46.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Role of oxidative damage in toxicity of particulates
AU - Møller, Peter
AU - Jacobsen, Nicklas R
AU - Folkmann, Janne K
AU - Danielsen, Pernille H
AU - Mikkelsen, Lone
AU - Hemmingsen, Jette G
AU - Vesterdal, Lise K
AU - Forchhammer, Lykke
AU - Wallin, Håkan
AU - Loft, Steffen
PY - 2010
Y1 - 2010
N2 - Particulates are small particles of solid or liquid suspended in liquid or air. In vitro studies show that particles generate reactive oxygen species, deplete endogenous antioxidants, alter mitochondrial function and produce oxidative damage to lipids and DNA. Surface area, reactivity and chemical composition play important roles in the oxidative potential of particulates. Studies in animal models indicate that particles from combustion processes (generated by combustion of wood or diesel oil), silicate, titanium dioxide and nanoparticles (C60 fullerenes and carbon nanotubes) produce elevated levels of lipid peroxidation products and oxidatively damaged DNA. Biomonitoring studies in humans have shown associations between exposure to air pollution and wood smoke particulates and oxidative damage to DNA, deoxynucleotides and lipids measured in leukocytes, plasma, urine and/or exhaled breath. The results indicate that oxidative stress and elevated levels of oxidatively altered biomolecules are important intermediate endpoints that may be useful markers in hazard characterization of particulates.
AB - Particulates are small particles of solid or liquid suspended in liquid or air. In vitro studies show that particles generate reactive oxygen species, deplete endogenous antioxidants, alter mitochondrial function and produce oxidative damage to lipids and DNA. Surface area, reactivity and chemical composition play important roles in the oxidative potential of particulates. Studies in animal models indicate that particles from combustion processes (generated by combustion of wood or diesel oil), silicate, titanium dioxide and nanoparticles (C60 fullerenes and carbon nanotubes) produce elevated levels of lipid peroxidation products and oxidatively damaged DNA. Biomonitoring studies in humans have shown associations between exposure to air pollution and wood smoke particulates and oxidative damage to DNA, deoxynucleotides and lipids measured in leukocytes, plasma, urine and/or exhaled breath. The results indicate that oxidative stress and elevated levels of oxidatively altered biomolecules are important intermediate endpoints that may be useful markers in hazard characterization of particulates.
U2 - 10.3109/10715760903300691
DO - 10.3109/10715760903300691
M3 - Journal article
C2 - 19886744
VL - 44
SP - 1
EP - 46
JO - Free Radical Research
JF - Free Radical Research
SN - 1071-5762
IS - 1
ER -
ID: 18360208