School performance and psychiatric morbidity 6 years after pediatric acute disseminated encephalomyelitis: A nationwide population-based cohort study

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School performance and psychiatric morbidity 6 years after pediatric acute disseminated encephalomyelitis : A nationwide population-based cohort study. / Boesen, Magnus Spangsberg; Langkilde, Annika; Born, Alfred Peter; Magyari, Melinda; Blinkenberg, Morten Bjørn; Chitnis, Tanuja; Thygesen, Lau Caspar; Eriksson, Frank.

In: Multiple Sclerosis and Related Disorders, Vol. 36, 101425, 2019.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Boesen, MS, Langkilde, A, Born, AP, Magyari, M, Blinkenberg, MB, Chitnis, T, Thygesen, LC & Eriksson, F 2019, 'School performance and psychiatric morbidity 6 years after pediatric acute disseminated encephalomyelitis: A nationwide population-based cohort study', Multiple Sclerosis and Related Disorders, vol. 36, 101425. https://doi.org/10.1016/j.msard.2019.101425

APA

Boesen, M. S., Langkilde, A., Born, A. P., Magyari, M., Blinkenberg, M. B., Chitnis, T., ... Eriksson, F. (2019). School performance and psychiatric morbidity 6 years after pediatric acute disseminated encephalomyelitis: A nationwide population-based cohort study. Multiple Sclerosis and Related Disorders, 36, [101425]. https://doi.org/10.1016/j.msard.2019.101425

Vancouver

Boesen MS, Langkilde A, Born AP, Magyari M, Blinkenberg MB, Chitnis T et al. School performance and psychiatric morbidity 6 years after pediatric acute disseminated encephalomyelitis: A nationwide population-based cohort study. Multiple Sclerosis and Related Disorders. 2019;36. 101425. https://doi.org/10.1016/j.msard.2019.101425

Author

Boesen, Magnus Spangsberg ; Langkilde, Annika ; Born, Alfred Peter ; Magyari, Melinda ; Blinkenberg, Morten Bjørn ; Chitnis, Tanuja ; Thygesen, Lau Caspar ; Eriksson, Frank. / School performance and psychiatric morbidity 6 years after pediatric acute disseminated encephalomyelitis : A nationwide population-based cohort study. In: Multiple Sclerosis and Related Disorders. 2019 ; Vol. 36.

Bibtex

@article{3f9e12d2155b41169fa5844172ac795c,
title = "School performance and psychiatric morbidity 6 years after pediatric acute disseminated encephalomyelitis: A nationwide population-based cohort study",
abstract = "BACKGROUND: Acute disseminated encephalomyelitis (ADEM) can cause cognitive impairment in children. However, long-term consequences for school performance and psychiatric morbidity have never been characterized. Our aim was to investigate long-term school performance and psychiatric morbidity after pediatric ADEM (<18 years).METHODS: We identified all children with ADEM 2008-2015 in Denmark using hospital diagnostic codes for acquired demyelinating syndromes. We reviewed all medical records to validate ADEM including blinded MRI review. Reference children were the entire pediatric (<18 years) population or randomly sampled sex and age-matched reference children. Outcomes were from nationwide population-based registers on special needs assistance, grade point average, highest completed education, in-hospital psychiatric hospital diagnoses, out-of-hospital psychiatric consultations or psychopharmacological drug prescriptions.RESULTS: 52 children had ADEM (median onset age: 5.5 years; median age at follow-up end: 13.4 years). Secondary school grade point average was similar among children with ADEM and reference children; however, children with ADEM had increased psychiatric morbidity (hazard ratio = 2.4; 95{\%} confidence interval = 1.2-5.1; p = 0.02), primarily due to increased drug prescriptions for sleep problems and depression.CONCLUSION: Children with prior ADEM have increased sleep problems and possibly also depression; however, school performance is seemingly unaffected. Clinicians should consider problems with sleep and mood at follow-up.",
author = "Boesen, {Magnus Spangsberg} and Annika Langkilde and Born, {Alfred Peter} and Melinda Magyari and Blinkenberg, {Morten Bj{\o}rn} and Tanuja Chitnis and Thygesen, {Lau Caspar} and Frank Eriksson",
note = "Copyright {\circledC} 2019 Elsevier B.V. All rights reserved.",
year = "2019",
doi = "10.1016/j.msard.2019.101425",
language = "English",
volume = "36",
journal = "Multiple Sclerosis and Related Disorders",
issn = "2211-0348",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - School performance and psychiatric morbidity 6 years after pediatric acute disseminated encephalomyelitis

T2 - A nationwide population-based cohort study

AU - Boesen, Magnus Spangsberg

AU - Langkilde, Annika

AU - Born, Alfred Peter

AU - Magyari, Melinda

AU - Blinkenberg, Morten Bjørn

AU - Chitnis, Tanuja

AU - Thygesen, Lau Caspar

AU - Eriksson, Frank

N1 - Copyright © 2019 Elsevier B.V. All rights reserved.

PY - 2019

Y1 - 2019

N2 - BACKGROUND: Acute disseminated encephalomyelitis (ADEM) can cause cognitive impairment in children. However, long-term consequences for school performance and psychiatric morbidity have never been characterized. Our aim was to investigate long-term school performance and psychiatric morbidity after pediatric ADEM (<18 years).METHODS: We identified all children with ADEM 2008-2015 in Denmark using hospital diagnostic codes for acquired demyelinating syndromes. We reviewed all medical records to validate ADEM including blinded MRI review. Reference children were the entire pediatric (<18 years) population or randomly sampled sex and age-matched reference children. Outcomes were from nationwide population-based registers on special needs assistance, grade point average, highest completed education, in-hospital psychiatric hospital diagnoses, out-of-hospital psychiatric consultations or psychopharmacological drug prescriptions.RESULTS: 52 children had ADEM (median onset age: 5.5 years; median age at follow-up end: 13.4 years). Secondary school grade point average was similar among children with ADEM and reference children; however, children with ADEM had increased psychiatric morbidity (hazard ratio = 2.4; 95% confidence interval = 1.2-5.1; p = 0.02), primarily due to increased drug prescriptions for sleep problems and depression.CONCLUSION: Children with prior ADEM have increased sleep problems and possibly also depression; however, school performance is seemingly unaffected. Clinicians should consider problems with sleep and mood at follow-up.

AB - BACKGROUND: Acute disseminated encephalomyelitis (ADEM) can cause cognitive impairment in children. However, long-term consequences for school performance and psychiatric morbidity have never been characterized. Our aim was to investigate long-term school performance and psychiatric morbidity after pediatric ADEM (<18 years).METHODS: We identified all children with ADEM 2008-2015 in Denmark using hospital diagnostic codes for acquired demyelinating syndromes. We reviewed all medical records to validate ADEM including blinded MRI review. Reference children were the entire pediatric (<18 years) population or randomly sampled sex and age-matched reference children. Outcomes were from nationwide population-based registers on special needs assistance, grade point average, highest completed education, in-hospital psychiatric hospital diagnoses, out-of-hospital psychiatric consultations or psychopharmacological drug prescriptions.RESULTS: 52 children had ADEM (median onset age: 5.5 years; median age at follow-up end: 13.4 years). Secondary school grade point average was similar among children with ADEM and reference children; however, children with ADEM had increased psychiatric morbidity (hazard ratio = 2.4; 95% confidence interval = 1.2-5.1; p = 0.02), primarily due to increased drug prescriptions for sleep problems and depression.CONCLUSION: Children with prior ADEM have increased sleep problems and possibly also depression; however, school performance is seemingly unaffected. Clinicians should consider problems with sleep and mood at follow-up.

U2 - 10.1016/j.msard.2019.101425

DO - 10.1016/j.msard.2019.101425

M3 - Journal article

C2 - 31655433

VL - 36

JO - Multiple Sclerosis and Related Disorders

JF - Multiple Sclerosis and Related Disorders

SN - 2211-0348

M1 - 101425

ER -

ID: 229372318