Selective loss of blood group antigens during wound healing

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Frozen sections of healing wounds of the oral mucosa of 3 rhesus monkeys were examined by a double layer immunofluorescent technic for the presence of blood group B-like antigens. Antigen activity was present in normal epithelium and in the epithelial outgrowth into the wounds but was absent from the outgrowth following treatment with lipid solvents. This finding suggests that glycoprotein but not glycolipid associated antigen is lost from the surface of epithelial cells during wound healing, a pattern of selective loss which may reflect a difference between regenerative and neoplastic lesions.
Original languageEnglish
JournalActa Pathologica et Microbiologica Scandinavica - Section A Pathology
Issue number6
Pages (from-to)445-450
Publication statusPublished - 1976
Externally publishedYes

ID: 137063471