Self-reported stress and risk of endometrial cancer: a prospective cohort study

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Standard

Self-reported stress and risk of endometrial cancer: a prospective cohort study. / Nielsen, Naja Rod; Strandberg-Larsen, Katrine; Grønbaek, Morten; Kristensen, Tage S; Schnohr, Peter; Zhang, Zuo-Feng.

In: Psychosomatic Medicine, Vol. 69, No. 4, 2007, p. 383-9.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Nielsen, NR, Strandberg-Larsen, K, Grønbaek, M, Kristensen, TS, Schnohr, P & Zhang, Z-F 2007, 'Self-reported stress and risk of endometrial cancer: a prospective cohort study', Psychosomatic Medicine, vol. 69, no. 4, pp. 383-9. https://doi.org/10.1097/PSY.0b013e31804301d3

APA

Nielsen, N. R., Strandberg-Larsen, K., Grønbaek, M., Kristensen, T. S., Schnohr, P., & Zhang, Z-F. (2007). Self-reported stress and risk of endometrial cancer: a prospective cohort study. Psychosomatic Medicine, 69(4), 383-9. https://doi.org/10.1097/PSY.0b013e31804301d3

Vancouver

Nielsen NR, Strandberg-Larsen K, Grønbaek M, Kristensen TS, Schnohr P, Zhang Z-F. Self-reported stress and risk of endometrial cancer: a prospective cohort study. Psychosomatic Medicine. 2007;69(4):383-9. https://doi.org/10.1097/PSY.0b013e31804301d3

Author

Nielsen, Naja Rod ; Strandberg-Larsen, Katrine ; Grønbaek, Morten ; Kristensen, Tage S ; Schnohr, Peter ; Zhang, Zuo-Feng. / Self-reported stress and risk of endometrial cancer: a prospective cohort study. In: Psychosomatic Medicine. 2007 ; Vol. 69, No. 4. pp. 383-9.

Bibtex

@article{08a8b510de3511ddb5fc000ea68e967b,
title = "Self-reported stress and risk of endometrial cancer: a prospective cohort study",
abstract = "OBJECTIVES: To assess a possible relationship between perceived stress and first-time incidence of primary endometrial cancer. Psychological stress may affect the synthesis and metabolism of estrogens and thereby be related to risk of endometrial cancer. METHODS: The 6760 women participating in the Copenhagen City Heart Study were asked about their stress level at baseline from 1981 to 1983. These women were prospectively followed up in the Danish nationwide cancer registry until 2000 and <0.1{\%} were lost to follow-up. Cox proportional hazard models were used to analyze data. RESULTS: During follow-up, 72 women were diagnosed with endometrial cancer. For each increase in stress level on a 7-point stress scale, there was a lower risk of primary endometrial cancer (hazard ratio (HR) = 0.88; 95{\%} confidence interval (CI), 0.76-1.01). This inverse association was particularly strong in women who received hormone therapy (HR = 0.77; 95{\%} CI, 0.61-0.96) and in normal-weight women (HR = 0.73; 95{\%} CI, 0.58-0.91). CONCLUSIONS: Stress may affect gonadal synthesis of estrogens and alter the sensitivity of the uterus toward estrogen stimulation. These mechanisms may explain the lower risk of endometrial cancer observed among stressed women in this study. Despite these results, stress may still be a risk factor for a range of other diseases and should therefore not be considered a healthy response.",
author = "Nielsen, {Naja Rod} and Katrine Strandberg-Larsen and Morten Gr{\o}nbaek and Kristensen, {Tage S} and Peter Schnohr and Zuo-Feng Zhang",
note = "Keywords: Adult; Aged; Aged, 80 and over; Cohort Studies; Endometrial Neoplasms; Estrogens; Female; Humans; Middle Aged; Prospective Studies; Risk Factors; Stress, Psychological",
year = "2007",
doi = "10.1097/PSY.0b013e31804301d3",
language = "English",
volume = "69",
pages = "383--9",
journal = "Psychosomatic Medicine",
issn = "0033-3174",
publisher = "Lippincott Williams & Wilkins",
number = "4",

}

RIS

TY - JOUR

T1 - Self-reported stress and risk of endometrial cancer: a prospective cohort study

AU - Nielsen, Naja Rod

AU - Strandberg-Larsen, Katrine

AU - Grønbaek, Morten

AU - Kristensen, Tage S

AU - Schnohr, Peter

AU - Zhang, Zuo-Feng

N1 - Keywords: Adult; Aged; Aged, 80 and over; Cohort Studies; Endometrial Neoplasms; Estrogens; Female; Humans; Middle Aged; Prospective Studies; Risk Factors; Stress, Psychological

PY - 2007

Y1 - 2007

N2 - OBJECTIVES: To assess a possible relationship between perceived stress and first-time incidence of primary endometrial cancer. Psychological stress may affect the synthesis and metabolism of estrogens and thereby be related to risk of endometrial cancer. METHODS: The 6760 women participating in the Copenhagen City Heart Study were asked about their stress level at baseline from 1981 to 1983. These women were prospectively followed up in the Danish nationwide cancer registry until 2000 and <0.1% were lost to follow-up. Cox proportional hazard models were used to analyze data. RESULTS: During follow-up, 72 women were diagnosed with endometrial cancer. For each increase in stress level on a 7-point stress scale, there was a lower risk of primary endometrial cancer (hazard ratio (HR) = 0.88; 95% confidence interval (CI), 0.76-1.01). This inverse association was particularly strong in women who received hormone therapy (HR = 0.77; 95% CI, 0.61-0.96) and in normal-weight women (HR = 0.73; 95% CI, 0.58-0.91). CONCLUSIONS: Stress may affect gonadal synthesis of estrogens and alter the sensitivity of the uterus toward estrogen stimulation. These mechanisms may explain the lower risk of endometrial cancer observed among stressed women in this study. Despite these results, stress may still be a risk factor for a range of other diseases and should therefore not be considered a healthy response.

AB - OBJECTIVES: To assess a possible relationship between perceived stress and first-time incidence of primary endometrial cancer. Psychological stress may affect the synthesis and metabolism of estrogens and thereby be related to risk of endometrial cancer. METHODS: The 6760 women participating in the Copenhagen City Heart Study were asked about their stress level at baseline from 1981 to 1983. These women were prospectively followed up in the Danish nationwide cancer registry until 2000 and <0.1% were lost to follow-up. Cox proportional hazard models were used to analyze data. RESULTS: During follow-up, 72 women were diagnosed with endometrial cancer. For each increase in stress level on a 7-point stress scale, there was a lower risk of primary endometrial cancer (hazard ratio (HR) = 0.88; 95% confidence interval (CI), 0.76-1.01). This inverse association was particularly strong in women who received hormone therapy (HR = 0.77; 95% CI, 0.61-0.96) and in normal-weight women (HR = 0.73; 95% CI, 0.58-0.91). CONCLUSIONS: Stress may affect gonadal synthesis of estrogens and alter the sensitivity of the uterus toward estrogen stimulation. These mechanisms may explain the lower risk of endometrial cancer observed among stressed women in this study. Despite these results, stress may still be a risk factor for a range of other diseases and should therefore not be considered a healthy response.

U2 - 10.1097/PSY.0b013e31804301d3

DO - 10.1097/PSY.0b013e31804301d3

M3 - Journal article

C2 - 17470667

VL - 69

SP - 383

EP - 389

JO - Psychosomatic Medicine

JF - Psychosomatic Medicine

SN - 0033-3174

IS - 4

ER -

ID: 9612128