Serum 25-hydroxyvitamin D and self-reported mental health status in adult Danes

Research output: Contribution to journalJournal articlepeer-review

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Serum 25-hydroxyvitamin D and self-reported mental health status in adult Danes. / Husemoen, L L N; Ebstrup, J F; Mortensen, E L; Schwarz, P; Skaaby, T; Thuesen, B H; Jørgensen, Torben; Linneberg, A.

In: European Journal of Clinical Nutrition, Vol. 70, No. 1, 01.2016, p. 78-84.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Husemoen, LLN, Ebstrup, JF, Mortensen, EL, Schwarz, P, Skaaby, T, Thuesen, BH, Jørgensen, T & Linneberg, A 2016, 'Serum 25-hydroxyvitamin D and self-reported mental health status in adult Danes', European Journal of Clinical Nutrition, vol. 70, no. 1, pp. 78-84. https://doi.org/10.1038/ejcn.2015.129

APA

Husemoen, L. L. N., Ebstrup, J. F., Mortensen, E. L., Schwarz, P., Skaaby, T., Thuesen, B. H., Jørgensen, T., & Linneberg, A. (2016). Serum 25-hydroxyvitamin D and self-reported mental health status in adult Danes. European Journal of Clinical Nutrition, 70(1), 78-84. https://doi.org/10.1038/ejcn.2015.129

Vancouver

Husemoen LLN, Ebstrup JF, Mortensen EL, Schwarz P, Skaaby T, Thuesen BH et al. Serum 25-hydroxyvitamin D and self-reported mental health status in adult Danes. European Journal of Clinical Nutrition. 2016 Jan;70(1):78-84. https://doi.org/10.1038/ejcn.2015.129

Author

Husemoen, L L N ; Ebstrup, J F ; Mortensen, E L ; Schwarz, P ; Skaaby, T ; Thuesen, B H ; Jørgensen, Torben ; Linneberg, A. / Serum 25-hydroxyvitamin D and self-reported mental health status in adult Danes. In: European Journal of Clinical Nutrition. 2016 ; Vol. 70, No. 1. pp. 78-84.

Bibtex

@article{13619416256a4411b0c9a0c16ef4c8f5,
title = "Serum 25-hydroxyvitamin D and self-reported mental health status in adult Danes",
abstract = "BACKGROUND/OBJECTIVES: Vitamin D receptors and vitamin D-metabolising enzymes are present in the brain and in the central nervous system at sites responsible for the regulation of emotions and behaviour. This raises the hypothesis that low vitamin D is related to poor mental health. Our aim was to examine the association between serum 25-hydroxyvitamin D (25(OH)D) and the self-reported symptoms and diagnosis of depression and anxiety in the adult general population.SUBJECTS/METHODS: Serum 25(OH)D was measured in three Danish population-based studies, including 5308 adults aged 18-64 years. After 5 years, 2004 participants were re-examined. Symptoms of depression and anxiety were assessed by the Symptom Check List (SCL)-90-R, and self-reported doctor-diagnosed depression and anxiety was recorded by using a questionnaire.RESULTS: Serum 25(OH)D was not associated with SCL average scores for depression and anxiety when analysed by quantile median regression adjusted for sex, age and other potential confounders. The β-coefficient and 95% confidence interval (CI) per 10 nmol/l serum 25(OH)D were 0.00 (-0.00 to 0.01) and P=0.23 for depression and -0.00 (-0.01 to 0.00) and P=0.19 for anxiety. Furthermore, no evidence of an association was observed with longitudinal changes (combining depression and anxiety score: β (95% CI)=0.00 (-0.00 to 0.00), P=0.90), with scores >90 percentiles (odds ratio (OR) (95% CI)=1.02 (0.98-1.07), P=0.32), or with self-reported history (OR (95% CI)=1.02 (0.97-1.07), P=0.47) or incidence (OR (95% CI)=1.02 (0.92-1.12), P=0.77) of doctor-diagnosed depression and/or anxiety.CONCLUSIONS: Our results suggest that low serum 25(OH)D is not associated with self-reported symptoms/diagnosis of depression and anxiety.",
keywords = "Journal Article, Research Support, Non-U.S. Gov't",
author = "Husemoen, {L L N} and Ebstrup, {J F} and Mortensen, {E L} and P Schwarz and T Skaaby and Thuesen, {B H} and Torben J{\o}rgensen and A Linneberg",
year = "2016",
month = jan,
doi = "10.1038/ejcn.2015.129",
language = "English",
volume = "70",
pages = "78--84",
journal = "European Journal of Clinical Nutrition",
issn = "0954-3007",
publisher = "nature publishing group",
number = "1",

}

RIS

TY - JOUR

T1 - Serum 25-hydroxyvitamin D and self-reported mental health status in adult Danes

AU - Husemoen, L L N

AU - Ebstrup, J F

AU - Mortensen, E L

AU - Schwarz, P

AU - Skaaby, T

AU - Thuesen, B H

AU - Jørgensen, Torben

AU - Linneberg, A

PY - 2016/1

Y1 - 2016/1

N2 - BACKGROUND/OBJECTIVES: Vitamin D receptors and vitamin D-metabolising enzymes are present in the brain and in the central nervous system at sites responsible for the regulation of emotions and behaviour. This raises the hypothesis that low vitamin D is related to poor mental health. Our aim was to examine the association between serum 25-hydroxyvitamin D (25(OH)D) and the self-reported symptoms and diagnosis of depression and anxiety in the adult general population.SUBJECTS/METHODS: Serum 25(OH)D was measured in three Danish population-based studies, including 5308 adults aged 18-64 years. After 5 years, 2004 participants were re-examined. Symptoms of depression and anxiety were assessed by the Symptom Check List (SCL)-90-R, and self-reported doctor-diagnosed depression and anxiety was recorded by using a questionnaire.RESULTS: Serum 25(OH)D was not associated with SCL average scores for depression and anxiety when analysed by quantile median regression adjusted for sex, age and other potential confounders. The β-coefficient and 95% confidence interval (CI) per 10 nmol/l serum 25(OH)D were 0.00 (-0.00 to 0.01) and P=0.23 for depression and -0.00 (-0.01 to 0.00) and P=0.19 for anxiety. Furthermore, no evidence of an association was observed with longitudinal changes (combining depression and anxiety score: β (95% CI)=0.00 (-0.00 to 0.00), P=0.90), with scores >90 percentiles (odds ratio (OR) (95% CI)=1.02 (0.98-1.07), P=0.32), or with self-reported history (OR (95% CI)=1.02 (0.97-1.07), P=0.47) or incidence (OR (95% CI)=1.02 (0.92-1.12), P=0.77) of doctor-diagnosed depression and/or anxiety.CONCLUSIONS: Our results suggest that low serum 25(OH)D is not associated with self-reported symptoms/diagnosis of depression and anxiety.

AB - BACKGROUND/OBJECTIVES: Vitamin D receptors and vitamin D-metabolising enzymes are present in the brain and in the central nervous system at sites responsible for the regulation of emotions and behaviour. This raises the hypothesis that low vitamin D is related to poor mental health. Our aim was to examine the association between serum 25-hydroxyvitamin D (25(OH)D) and the self-reported symptoms and diagnosis of depression and anxiety in the adult general population.SUBJECTS/METHODS: Serum 25(OH)D was measured in three Danish population-based studies, including 5308 adults aged 18-64 years. After 5 years, 2004 participants were re-examined. Symptoms of depression and anxiety were assessed by the Symptom Check List (SCL)-90-R, and self-reported doctor-diagnosed depression and anxiety was recorded by using a questionnaire.RESULTS: Serum 25(OH)D was not associated with SCL average scores for depression and anxiety when analysed by quantile median regression adjusted for sex, age and other potential confounders. The β-coefficient and 95% confidence interval (CI) per 10 nmol/l serum 25(OH)D were 0.00 (-0.00 to 0.01) and P=0.23 for depression and -0.00 (-0.01 to 0.00) and P=0.19 for anxiety. Furthermore, no evidence of an association was observed with longitudinal changes (combining depression and anxiety score: β (95% CI)=0.00 (-0.00 to 0.00), P=0.90), with scores >90 percentiles (odds ratio (OR) (95% CI)=1.02 (0.98-1.07), P=0.32), or with self-reported history (OR (95% CI)=1.02 (0.97-1.07), P=0.47) or incidence (OR (95% CI)=1.02 (0.92-1.12), P=0.77) of doctor-diagnosed depression and/or anxiety.CONCLUSIONS: Our results suggest that low serum 25(OH)D is not associated with self-reported symptoms/diagnosis of depression and anxiety.

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1038/ejcn.2015.129

DO - 10.1038/ejcn.2015.129

M3 - Journal article

C2 - 26264349

VL - 70

SP - 78

EP - 84

JO - European Journal of Clinical Nutrition

JF - European Journal of Clinical Nutrition

SN - 0954-3007

IS - 1

ER -

ID: 164159501