Severe COVID-19 during pregnancy in Sweden, Norway, and Denmark

Research output: Contribution to journalJournal articlepeer-review

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Severe COVID-19 during pregnancy in Sweden, Norway, and Denmark. / Örtqvist, Anne K; Magnus, Maria C; Aabakke, Anna J M; Urhoj, Stine Kjaer; Vinkel Hansen, Anne; Nybo Andersen, Anne-Marie; Krebs, Lone; Pettersson, Karin; Håberg, Siri E; Stephansson, Olof.

In: Acta Obstetricia et Gynecologica Scandinavica, Vol. 102, No. 6, 2023, p. 681-689.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Örtqvist, AK, Magnus, MC, Aabakke, AJM, Urhoj, SK, Vinkel Hansen, A, Nybo Andersen, A-M, Krebs, L, Pettersson, K, Håberg, SE & Stephansson, O 2023, 'Severe COVID-19 during pregnancy in Sweden, Norway, and Denmark', Acta Obstetricia et Gynecologica Scandinavica, vol. 102, no. 6, pp. 681-689. https://doi.org/10.1111/aogs.14552

APA

Örtqvist, A. K., Magnus, M. C., Aabakke, A. J. M., Urhoj, S. K., Vinkel Hansen, A., Nybo Andersen, A-M., Krebs, L., Pettersson, K., Håberg, S. E., & Stephansson, O. (2023). Severe COVID-19 during pregnancy in Sweden, Norway, and Denmark. Acta Obstetricia et Gynecologica Scandinavica, 102(6), 681-689. https://doi.org/10.1111/aogs.14552

Vancouver

Örtqvist AK, Magnus MC, Aabakke AJM, Urhoj SK, Vinkel Hansen A, Nybo Andersen A-M et al. Severe COVID-19 during pregnancy in Sweden, Norway, and Denmark. Acta Obstetricia et Gynecologica Scandinavica. 2023;102(6):681-689. https://doi.org/10.1111/aogs.14552

Author

Örtqvist, Anne K ; Magnus, Maria C ; Aabakke, Anna J M ; Urhoj, Stine Kjaer ; Vinkel Hansen, Anne ; Nybo Andersen, Anne-Marie ; Krebs, Lone ; Pettersson, Karin ; Håberg, Siri E ; Stephansson, Olof. / Severe COVID-19 during pregnancy in Sweden, Norway, and Denmark. In: Acta Obstetricia et Gynecologica Scandinavica. 2023 ; Vol. 102, No. 6. pp. 681-689.

Bibtex

@article{a4351ebdb2734365972e089dfcf39989,
title = "Severe COVID-19 during pregnancy in Sweden, Norway, and Denmark",
abstract = "INTRODUCTION: Pregnancy is a risk factor for severe coronavirus disease 2019 (COVID-19) and adverse pregnancy outcomes. We aimed to explore maternal characteristics, pregnancy outcomes, vaccination status, and virus variants among pregnant women admitted to intensive care units (ICU) with severe COVID-19.MATERIAL AND METHODS: We identified pregnant women admitted to ICU in Sweden (n = 96), Norway (n = 31), and Denmark (n = 16) because of severe COVID-19, from national registers and clinical databases between March 2020 and February 2022 (Denmark), August 2022 (Sweden), or December 2022 (Norway). Their background characteristics, pregnancy outcome, and vaccination status were compared with all birthing women and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) test-positive pregnant women during the same time period. We calculated the number admitted to ICU per 10 000 birthing and per 1000 SARS-CoV-2 test-positive women during the Index, Alpha, Delta, and Omicron periods.RESULTS: Women admitted to ICU had a higher mean body mass index, were more often of non-Scandinavian origin, had on average lower education and income levels, had a higher proportion of chronic and pregnancy-related conditions, delivered preterm, had neonates with low Apgar scores, and had more infants admitted to neonatal care, compared with all birthing and test-positive pregnant women. Of those admitted to ICU, only 7% had been vaccinated before admission. Overall, the highest proportion of women admitted to ICU per birthing was during the Delta period (4.1 per 10 000 birthing women). In Norway, the highest proportion admitted to ICU per test-positive pregnant women was during the Delta period (17.8 per 1000 test-positive), whereas the highest proportion of admitted per test-positive in Sweden and Denmark was seen during the Index period (15.4 and 8.9 per 1000 test-positive, respectively).CONCLUSIONS: Admission to ICU because of COVID-19 in pregnancy was a rare event in the Scandinavian countries, but women who were unvaccinated, of non-Scandinavian origin, and with lower socio-economic status were at higher risk of admission to ICU. In addition, women admitted to ICU for COVID-19 had higher risk of adverse pregnancy outcomes.",
author = "{\"O}rtqvist, {Anne K} and Magnus, {Maria C} and Aabakke, {Anna J M} and Urhoj, {Stine Kjaer} and {Vinkel Hansen}, Anne and {Nybo Andersen}, Anne-Marie and Lone Krebs and Karin Pettersson and H{\aa}berg, {Siri E} and Olof Stephansson",
note = "{\textcopyright} 2023 The Authors. Acta Obstetricia et Gynecologica Scandinavica published by John Wiley & Sons Ltd on behalf of Nordic Federation of Societies of Obstetrics and Gynecology (NFOG).",
year = "2023",
doi = "10.1111/aogs.14552",
language = "English",
volume = "102",
pages = "681--689",
journal = "Acta Obstetricia et Gynecologica Scandinavica",
issn = "0001-6349",
publisher = "JohnWiley & Sons Ltd",
number = "6",

}

RIS

TY - JOUR

T1 - Severe COVID-19 during pregnancy in Sweden, Norway, and Denmark

AU - Örtqvist, Anne K

AU - Magnus, Maria C

AU - Aabakke, Anna J M

AU - Urhoj, Stine Kjaer

AU - Vinkel Hansen, Anne

AU - Nybo Andersen, Anne-Marie

AU - Krebs, Lone

AU - Pettersson, Karin

AU - Håberg, Siri E

AU - Stephansson, Olof

N1 - © 2023 The Authors. Acta Obstetricia et Gynecologica Scandinavica published by John Wiley & Sons Ltd on behalf of Nordic Federation of Societies of Obstetrics and Gynecology (NFOG).

PY - 2023

Y1 - 2023

N2 - INTRODUCTION: Pregnancy is a risk factor for severe coronavirus disease 2019 (COVID-19) and adverse pregnancy outcomes. We aimed to explore maternal characteristics, pregnancy outcomes, vaccination status, and virus variants among pregnant women admitted to intensive care units (ICU) with severe COVID-19.MATERIAL AND METHODS: We identified pregnant women admitted to ICU in Sweden (n = 96), Norway (n = 31), and Denmark (n = 16) because of severe COVID-19, from national registers and clinical databases between March 2020 and February 2022 (Denmark), August 2022 (Sweden), or December 2022 (Norway). Their background characteristics, pregnancy outcome, and vaccination status were compared with all birthing women and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) test-positive pregnant women during the same time period. We calculated the number admitted to ICU per 10 000 birthing and per 1000 SARS-CoV-2 test-positive women during the Index, Alpha, Delta, and Omicron periods.RESULTS: Women admitted to ICU had a higher mean body mass index, were more often of non-Scandinavian origin, had on average lower education and income levels, had a higher proportion of chronic and pregnancy-related conditions, delivered preterm, had neonates with low Apgar scores, and had more infants admitted to neonatal care, compared with all birthing and test-positive pregnant women. Of those admitted to ICU, only 7% had been vaccinated before admission. Overall, the highest proportion of women admitted to ICU per birthing was during the Delta period (4.1 per 10 000 birthing women). In Norway, the highest proportion admitted to ICU per test-positive pregnant women was during the Delta period (17.8 per 1000 test-positive), whereas the highest proportion of admitted per test-positive in Sweden and Denmark was seen during the Index period (15.4 and 8.9 per 1000 test-positive, respectively).CONCLUSIONS: Admission to ICU because of COVID-19 in pregnancy was a rare event in the Scandinavian countries, but women who were unvaccinated, of non-Scandinavian origin, and with lower socio-economic status were at higher risk of admission to ICU. In addition, women admitted to ICU for COVID-19 had higher risk of adverse pregnancy outcomes.

AB - INTRODUCTION: Pregnancy is a risk factor for severe coronavirus disease 2019 (COVID-19) and adverse pregnancy outcomes. We aimed to explore maternal characteristics, pregnancy outcomes, vaccination status, and virus variants among pregnant women admitted to intensive care units (ICU) with severe COVID-19.MATERIAL AND METHODS: We identified pregnant women admitted to ICU in Sweden (n = 96), Norway (n = 31), and Denmark (n = 16) because of severe COVID-19, from national registers and clinical databases between March 2020 and February 2022 (Denmark), August 2022 (Sweden), or December 2022 (Norway). Their background characteristics, pregnancy outcome, and vaccination status were compared with all birthing women and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) test-positive pregnant women during the same time period. We calculated the number admitted to ICU per 10 000 birthing and per 1000 SARS-CoV-2 test-positive women during the Index, Alpha, Delta, and Omicron periods.RESULTS: Women admitted to ICU had a higher mean body mass index, were more often of non-Scandinavian origin, had on average lower education and income levels, had a higher proportion of chronic and pregnancy-related conditions, delivered preterm, had neonates with low Apgar scores, and had more infants admitted to neonatal care, compared with all birthing and test-positive pregnant women. Of those admitted to ICU, only 7% had been vaccinated before admission. Overall, the highest proportion of women admitted to ICU per birthing was during the Delta period (4.1 per 10 000 birthing women). In Norway, the highest proportion admitted to ICU per test-positive pregnant women was during the Delta period (17.8 per 1000 test-positive), whereas the highest proportion of admitted per test-positive in Sweden and Denmark was seen during the Index period (15.4 and 8.9 per 1000 test-positive, respectively).CONCLUSIONS: Admission to ICU because of COVID-19 in pregnancy was a rare event in the Scandinavian countries, but women who were unvaccinated, of non-Scandinavian origin, and with lower socio-economic status were at higher risk of admission to ICU. In addition, women admitted to ICU for COVID-19 had higher risk of adverse pregnancy outcomes.

U2 - 10.1111/aogs.14552

DO - 10.1111/aogs.14552

M3 - Journal article

C2 - 36928990

VL - 102

SP - 681

EP - 689

JO - Acta Obstetricia et Gynecologica Scandinavica

JF - Acta Obstetricia et Gynecologica Scandinavica

SN - 0001-6349

IS - 6

ER -

ID: 339620820