Short-term acetaminophen consumption enhances the exercise-induced increase in Achilles peritendinous IL-6 in humans
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Short-term acetaminophen consumption enhances the exercise-induced increase in Achilles peritendinous IL-6 in humans. / Gump, Brian S; McMullan, David R; Cauthon, David J; Whitt, Jamie A; Del Mundo, Jonathon D; Letham, Tanya; Kim, Paul J; Friedlander, Gary N; Pingel, Jessica; Langberg, Henning; Carroll, Chad C.
In: Journal of Applied Physiology, Vol. 115, No. 6, 2013, p. 929-936.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Short-term acetaminophen consumption enhances the exercise-induced increase in Achilles peritendinous IL-6 in humans
AU - Gump, Brian S
AU - McMullan, David R
AU - Cauthon, David J
AU - Whitt, Jamie A
AU - Del Mundo, Jonathon D
AU - Letham, Tanya
AU - Kim, Paul J
AU - Friedlander, Gary N
AU - Pingel, Jessica
AU - Langberg, Henning
AU - Carroll, Chad C
N1 - CURIS 2013 NEXS 274
PY - 2013
Y1 - 2013
N2 - Through an unknown mechanism the cyclooxygenase (COX) inhibitor acetaminophen (APAP) alters tendon mechanical properties in humans when consumed during exercise. Interleukin-6 (IL-6) is produced by tendon during exercise and is a potent stimulator of collagen synthesis. In non-tendon tissue, IL-6 is upregulated in presence of COX-inhibitors and may contribute to alterations in extracellular matrix turnover, possibly due to inhibition of prostaglandin E2 (PGE2). We evaluated the effects of APAP on IL-6 and PGE2 in human Achilles peritendinous tissue after 1-hour of treadmill exercise. Subjects were randomly assigned to a placebo (n=8, 26±1 y) or APAP (n=8, 25±1 y) group. Each subject completed a non-exercise and exercise experiment consisting of 6-hours of microdialysis. Drug (APAP, 1000 mg) or placebo was administered in a double-blind manner during both experiments. PGE2 and IL-6 were determined via enzyme immunoassay and APAP via high performance liquid chromatography. In subjects given APAP, peritendinous APAP levels increased to 4.08±0.65 μg•ml(-1) (p0.05), nor was PGE2 significantly reduced in the APAP group. IL-6 levels increased with exercise in both groups (p
AB - Through an unknown mechanism the cyclooxygenase (COX) inhibitor acetaminophen (APAP) alters tendon mechanical properties in humans when consumed during exercise. Interleukin-6 (IL-6) is produced by tendon during exercise and is a potent stimulator of collagen synthesis. In non-tendon tissue, IL-6 is upregulated in presence of COX-inhibitors and may contribute to alterations in extracellular matrix turnover, possibly due to inhibition of prostaglandin E2 (PGE2). We evaluated the effects of APAP on IL-6 and PGE2 in human Achilles peritendinous tissue after 1-hour of treadmill exercise. Subjects were randomly assigned to a placebo (n=8, 26±1 y) or APAP (n=8, 25±1 y) group. Each subject completed a non-exercise and exercise experiment consisting of 6-hours of microdialysis. Drug (APAP, 1000 mg) or placebo was administered in a double-blind manner during both experiments. PGE2 and IL-6 were determined via enzyme immunoassay and APAP via high performance liquid chromatography. In subjects given APAP, peritendinous APAP levels increased to 4.08±0.65 μg•ml(-1) (p0.05), nor was PGE2 significantly reduced in the APAP group. IL-6 levels increased with exercise in both groups (p
U2 - 10.1152/japplphysiol.00219.2013
DO - 10.1152/japplphysiol.00219.2013
M3 - Journal article
C2 - 23743397
VL - 115
SP - 929
EP - 936
JO - Journal of Applied Physiology
JF - Journal of Applied Physiology
SN - 8750-7587
IS - 6
ER -
ID: 46148542