Single nucleotide polymorphisms in genes encoding toll-like receptors 7, 8 and 9 in Danish patients with systemic lupus erythematosus

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Single nucleotide polymorphisms in genes encoding toll-like receptors 7, 8 and 9 in Danish patients with systemic lupus erythematosus. / Enevold, C; Nielsen, Claus Henrik; Jacobsen, Rasmus Sleimann; Hermansen, Marie-Louise From; Molbo, Drude; Avlund, Kirsten; Bendtzen, Klaus; Jacobsen, Søren.

In: Molecular Biology Reports, Vol. 41, No. 9, 2014, p. 5755-5763.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Enevold, C, Nielsen, CH, Jacobsen, RS, Hermansen, M-LF, Molbo, D, Avlund, K, Bendtzen, K & Jacobsen, S 2014, 'Single nucleotide polymorphisms in genes encoding toll-like receptors 7, 8 and 9 in Danish patients with systemic lupus erythematosus', Molecular Biology Reports, vol. 41, no. 9, pp. 5755-5763. https://doi.org/10.1007/s11033-014-3447-4

APA

Enevold, C., Nielsen, C. H., Jacobsen, R. S., Hermansen, M-L. F., Molbo, D., Avlund, K., Bendtzen, K., & Jacobsen, S. (2014). Single nucleotide polymorphisms in genes encoding toll-like receptors 7, 8 and 9 in Danish patients with systemic lupus erythematosus. Molecular Biology Reports, 41(9), 5755-5763. https://doi.org/10.1007/s11033-014-3447-4

Vancouver

Enevold C, Nielsen CH, Jacobsen RS, Hermansen M-LF, Molbo D, Avlund K et al. Single nucleotide polymorphisms in genes encoding toll-like receptors 7, 8 and 9 in Danish patients with systemic lupus erythematosus. Molecular Biology Reports. 2014;41(9):5755-5763. https://doi.org/10.1007/s11033-014-3447-4

Author

Enevold, C ; Nielsen, Claus Henrik ; Jacobsen, Rasmus Sleimann ; Hermansen, Marie-Louise From ; Molbo, Drude ; Avlund, Kirsten ; Bendtzen, Klaus ; Jacobsen, Søren. / Single nucleotide polymorphisms in genes encoding toll-like receptors 7, 8 and 9 in Danish patients with systemic lupus erythematosus. In: Molecular Biology Reports. 2014 ; Vol. 41, No. 9. pp. 5755-5763.

Bibtex

@article{8ed78814c53b4f2b9e398c408a0a48dc,
title = "Single nucleotide polymorphisms in genes encoding toll-like receptors 7, 8 and 9 in Danish patients with systemic lupus erythematosus",
abstract = "Several studies indicate a role for toll-like receptors (TLRs) in the pathogenesis of systemic lupus erythematosus (SLE). We aimed to investigate the risk of SLE and typical clinical and serological manifestations of SLE potentially conferred by selected single nucleotide polymorphisms (SNPs) of genes encoding TLR7, TLR8, and TLR9. Using a multiplexed bead-based assay, we analyzed eight SNPs in a cohort of 142 Danish SLE patients and a gender-matched control cohort comprising 443 individuals. Our results showed an association between the rs3853839 polymorphism of TLR7 and SLE (G vs. C, P = 0.008, OR 1.60, 95 % CI 1.12-2.27 in females; P = 0.02, OR 4.50, 95 % CI 1.18-16.7 in males) confirming recent findings in other populations. Additionally, an association between the rs3764879 polymorphism of TLR8 and SLE (G vs. C, P < 0.05, OR 1.36, 95 % CI 0.99-1.86 in females; P = 0.06, OR 4.00, 95 % CI 0.90-17.3 in males) was found. None of the other investigated SNPs were associated with SLE but several SNPs were associated with clinical and serological manifestations. In summary, a previously shown association between the rs3853839 SNP of TLR7 and SLE in Asian patients was also found in Danish patients. Together with the association of several other SNPs of TLR8 and TLR9 with various clinical and serological manifestations of SLE these findings corroborate the pathogenic significance of TLRs in SLE.",
author = "C Enevold and Nielsen, {Claus Henrik} and Jacobsen, {Rasmus Sleimann} and Hermansen, {Marie-Louise From} and Drude Molbo and Kirsten Avlund and Klaus Bendtzen and S{\o}ren Jacobsen",
year = "2014",
doi = "10.1007/s11033-014-3447-4",
language = "English",
volume = "41",
pages = "5755--5763",
journal = "Molecular Biology Reports",
issn = "0301-4851",
publisher = "Springer",
number = "9",

}

RIS

TY - JOUR

T1 - Single nucleotide polymorphisms in genes encoding toll-like receptors 7, 8 and 9 in Danish patients with systemic lupus erythematosus

AU - Enevold, C

AU - Nielsen, Claus Henrik

AU - Jacobsen, Rasmus Sleimann

AU - Hermansen, Marie-Louise From

AU - Molbo, Drude

AU - Avlund, Kirsten

AU - Bendtzen, Klaus

AU - Jacobsen, Søren

PY - 2014

Y1 - 2014

N2 - Several studies indicate a role for toll-like receptors (TLRs) in the pathogenesis of systemic lupus erythematosus (SLE). We aimed to investigate the risk of SLE and typical clinical and serological manifestations of SLE potentially conferred by selected single nucleotide polymorphisms (SNPs) of genes encoding TLR7, TLR8, and TLR9. Using a multiplexed bead-based assay, we analyzed eight SNPs in a cohort of 142 Danish SLE patients and a gender-matched control cohort comprising 443 individuals. Our results showed an association between the rs3853839 polymorphism of TLR7 and SLE (G vs. C, P = 0.008, OR 1.60, 95 % CI 1.12-2.27 in females; P = 0.02, OR 4.50, 95 % CI 1.18-16.7 in males) confirming recent findings in other populations. Additionally, an association between the rs3764879 polymorphism of TLR8 and SLE (G vs. C, P < 0.05, OR 1.36, 95 % CI 0.99-1.86 in females; P = 0.06, OR 4.00, 95 % CI 0.90-17.3 in males) was found. None of the other investigated SNPs were associated with SLE but several SNPs were associated with clinical and serological manifestations. In summary, a previously shown association between the rs3853839 SNP of TLR7 and SLE in Asian patients was also found in Danish patients. Together with the association of several other SNPs of TLR8 and TLR9 with various clinical and serological manifestations of SLE these findings corroborate the pathogenic significance of TLRs in SLE.

AB - Several studies indicate a role for toll-like receptors (TLRs) in the pathogenesis of systemic lupus erythematosus (SLE). We aimed to investigate the risk of SLE and typical clinical and serological manifestations of SLE potentially conferred by selected single nucleotide polymorphisms (SNPs) of genes encoding TLR7, TLR8, and TLR9. Using a multiplexed bead-based assay, we analyzed eight SNPs in a cohort of 142 Danish SLE patients and a gender-matched control cohort comprising 443 individuals. Our results showed an association between the rs3853839 polymorphism of TLR7 and SLE (G vs. C, P = 0.008, OR 1.60, 95 % CI 1.12-2.27 in females; P = 0.02, OR 4.50, 95 % CI 1.18-16.7 in males) confirming recent findings in other populations. Additionally, an association between the rs3764879 polymorphism of TLR8 and SLE (G vs. C, P < 0.05, OR 1.36, 95 % CI 0.99-1.86 in females; P = 0.06, OR 4.00, 95 % CI 0.90-17.3 in males) was found. None of the other investigated SNPs were associated with SLE but several SNPs were associated with clinical and serological manifestations. In summary, a previously shown association between the rs3853839 SNP of TLR7 and SLE in Asian patients was also found in Danish patients. Together with the association of several other SNPs of TLR8 and TLR9 with various clinical and serological manifestations of SLE these findings corroborate the pathogenic significance of TLRs in SLE.

U2 - 10.1007/s11033-014-3447-4

DO - 10.1007/s11033-014-3447-4

M3 - Journal article

C2 - 24919757

VL - 41

SP - 5755

EP - 5763

JO - Molecular Biology Reports

JF - Molecular Biology Reports

SN - 0301-4851

IS - 9

ER -

ID: 120409860