Temocene: the porphycene analogue of temoporfin (Foscan®)

Research output: Contribution to journalJournal articleResearchpeer-review

Maria Garcia-Diaz, David Sanchez-Garcia, Santi Nonell, Jorge Soriano, Angeles Villanueva, Juan Carlos Stockert, Magdalena Canete, Maria Lluisa Sagrista, Margarita Mora

Temocene, a porphycene analogue of temoporfin, has been synthesized. Compared to temoporfin, temocene is endowed with 2.5-fold larger absorption coefficients in the red part of the spectrum while keeping its excellent photophysical and singlet oxygen photosensitization ability. While its photodynamic activity towards HeLa cells is lower than that of temoporfin, its higher photostability, lower dark toxicity and mitochondrial localisation make temocene a promising candidate for photodynamic therapy applications.
Original languageEnglish
JournalMedChemComm
Volume2
Issue number7
Pages (from-to)616-619
Number of pages4
ISSN2040-2503
DOIs
Publication statusPublished - 1 Jul 2011
Externally publishedYes

ID: 46457104