The apolipoprotein E epsilon4-allele and antihypertensive treatment are associated with increased risk of cerebral MRI white matter hyperintensities.

Research output: Contribution to journal › Journal article › peer-review

Standard

The apolipoprotein E epsilon4-allele and antihypertensive treatment are associated with increased risk of cerebral MRI white matter hyperintensities. / Høgh, P; Garde, Ellen; Mortensen, Erik Lykke; Jorgensen, O. S.; Krabbe, Katrine; Waldemar, G.

In: Acta Neurologica Scandinavica, Vol. 115, No. 4, 2007, p. 248-53.

Research output: Contribution to journal › Journal article › peer-review

Harvard

Høgh, P, Garde, E, Mortensen, EL, Jorgensen, OS, Krabbe, K & Waldemar, G 2007, 'The apolipoprotein E epsilon4-allele and antihypertensive treatment are associated with increased risk of cerebral MRI white matter hyperintensities.', Acta Neurologica Scandinavica, vol. 115, no. 4, pp. 248-53. https://doi.org/10.1111/j.1600-0404.2006.00779.x

APA

Høgh, P., Garde, E., Mortensen, E. L., Jorgensen, O. S., Krabbe, K., & Waldemar, G. (2007). The apolipoprotein E epsilon4-allele and antihypertensive treatment are associated with increased risk of cerebral MRI white matter hyperintensities. Acta Neurologica Scandinavica, 115(4), 248-53. https://doi.org/10.1111/j.1600-0404.2006.00779.x

Vancouver

Høgh P, Garde E, Mortensen EL, Jorgensen OS, Krabbe K, Waldemar G. The apolipoprotein E epsilon4-allele and antihypertensive treatment are associated with increased risk of cerebral MRI white matter hyperintensities. Acta Neurologica Scandinavica. 2007;115(4):248-53. https://doi.org/10.1111/j.1600-0404.2006.00779.x

Author

Høgh, P ; Garde, Ellen ; Mortensen, Erik Lykke ; Jorgensen, O. S. ; Krabbe, Katrine ; Waldemar, G. / The apolipoprotein E epsilon4-allele and antihypertensive treatment are associated with increased risk of cerebral MRI white matter hyperintensities. In: Acta Neurologica Scandinavica. 2007 ; Vol. 115, No. 4. pp. 248-53.

Bibtex

@article{be5c2780aa7c11ddb5e9000ea68e967b,
title = "The apolipoprotein E epsilon4-allele and antihypertensive treatment are associated with increased risk of cerebral MRI white matter hyperintensities.",
abstract = "OBJECTIVE: Apolipoprotein E-epsilon4 (APOE-epsilon4) is a potential risk factor for cerebral vascular disease. The aim of the present study was to examine the relative importance of APOE-epsilon4 and other relevant risk factors for the extent of cerebral white matter hyperintensity (WMH) in a community-based sample of elderly subjects. MATERIALS AND METHODS: From a cohort of 976 subjects born in 1914, APOE genotype was determined and MRI examinations were carried out in 75 subjects. WMH were rated using a standard semi-quantitative method. ANOVA and regression analyses were conducted to explore the relative importance of the potential risk factors. RESULTS: APOE genotype and antihypertensive treatment were significantly associated with severity of total WMH load (P < 0.05). CONCLUSIONS: The study confirmed the association between APOE-epsilon4 and WMH. Pharmaceutical treatment for arterial hypertension was also associated with the total burden of WMH in this study.",
author = "P H{\o}gh and Ellen Garde and Mortensen, {Erik Lykke} and Jorgensen, {O. S.} and Katrine Krabbe and G Waldemar",
note = "Keywords: Aged, 80 and over; Alcohol Drinking; Antihypertensive Agents; Apolipoprotein E4; Brain; Cohort Studies; Female; Genotype; Humans; Magnetic Resonance Imaging; Male; Risk Factors",
year = "2007",
doi = "10.1111/j.1600-0404.2006.00779.x",
language = "English",
volume = "115",
pages = "248--53",
journal = "Acta Neurologica Scandinavica",
issn = "0001-6314",
publisher = "Wiley-Blackwell",
number = "4",

}

RIS

TY - JOUR

T1 - The apolipoprotein E epsilon4-allele and antihypertensive treatment are associated with increased risk of cerebral MRI white matter hyperintensities.

AU - Høgh, P

AU - Garde, Ellen

AU - Mortensen, Erik Lykke

AU - Jorgensen, O. S.

AU - Krabbe, Katrine

AU - Waldemar, G

N1 - Keywords: Aged, 80 and over; Alcohol Drinking; Antihypertensive Agents; Apolipoprotein E4; Brain; Cohort Studies; Female; Genotype; Humans; Magnetic Resonance Imaging; Male; Risk Factors

PY - 2007

Y1 - 2007

N2 - OBJECTIVE: Apolipoprotein E-epsilon4 (APOE-epsilon4) is a potential risk factor for cerebral vascular disease. The aim of the present study was to examine the relative importance of APOE-epsilon4 and other relevant risk factors for the extent of cerebral white matter hyperintensity (WMH) in a community-based sample of elderly subjects. MATERIALS AND METHODS: From a cohort of 976 subjects born in 1914, APOE genotype was determined and MRI examinations were carried out in 75 subjects. WMH were rated using a standard semi-quantitative method. ANOVA and regression analyses were conducted to explore the relative importance of the potential risk factors. RESULTS: APOE genotype and antihypertensive treatment were significantly associated with severity of total WMH load (P < 0.05). CONCLUSIONS: The study confirmed the association between APOE-epsilon4 and WMH. Pharmaceutical treatment for arterial hypertension was also associated with the total burden of WMH in this study.

AB - OBJECTIVE: Apolipoprotein E-epsilon4 (APOE-epsilon4) is a potential risk factor for cerebral vascular disease. The aim of the present study was to examine the relative importance of APOE-epsilon4 and other relevant risk factors for the extent of cerebral white matter hyperintensity (WMH) in a community-based sample of elderly subjects. MATERIALS AND METHODS: From a cohort of 976 subjects born in 1914, APOE genotype was determined and MRI examinations were carried out in 75 subjects. WMH were rated using a standard semi-quantitative method. ANOVA and regression analyses were conducted to explore the relative importance of the potential risk factors. RESULTS: APOE genotype and antihypertensive treatment were significantly associated with severity of total WMH load (P < 0.05). CONCLUSIONS: The study confirmed the association between APOE-epsilon4 and WMH. Pharmaceutical treatment for arterial hypertension was also associated with the total burden of WMH in this study.

U2 - 10.1111/j.1600-0404.2006.00779.x

DO - 10.1111/j.1600-0404.2006.00779.x

M3 - Journal article

C2 - 17376122

VL - 115

SP - 248

EP - 253

JO - Acta Neurologica Scandinavica

JF - Acta Neurologica Scandinavica

SN - 0001-6314

IS - 4

ER -

ID: 8396453