The association of pre-pregnancy alcohol drinking with child neuropsychological functioning
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The association of pre-pregnancy alcohol drinking with child neuropsychological functioning. / Kesmodel, Ulrik Schiøler; Kjaersgaard, M. I. S.; Denny, C. H.; Bertrand, J.; Skogerbø, A.; Eriksen, H-LF; Bay, B.; Underbjerg, M.; Mortensen, E. L.
In: B J O G, Vol. 122, No. 13, 12.2015, p. 1728-1738.Research output: Contribution to journal › Journal article › peer-review
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TY - JOUR
T1 - The association of pre-pregnancy alcohol drinking with child neuropsychological functioning
AU - Kesmodel, Ulrik Schiøler
AU - Kjaersgaard, M. I. S.
AU - Denny, C. H.
AU - Bertrand, J.
AU - Skogerbø, A.
AU - Eriksen, H-LF
AU - Bay, B.
AU - Underbjerg, M.
AU - Mortensen, E. L.
PY - 2015/12
Y1 - 2015/12
N2 - Objective: To examine the effects of pre-pregnancy alcohol drinking on child neuropsychological functioning.Design: Prospective follow-up study.Setting and population: 154 women and their children sampled from the Danish National Birth Cohort.Methods: Participants were sampled based on maternal alcohol consumption before pregnancy. At 5 years of age, the children were tested with the Wechsler Preschool and Primary Scale of Intelligence-Revised, the Test of Everyday Attention for Children atFive (TEACh-5), and the Movement Assessment Battery for Children (MABC). The Behaviour Rating Inventory of Executive Function (BRIEF) was completed by the mothers and a preschool teacher. Parental education, maternal IQ, prenatal maternal smoking, child’s age at testing, child’s sex, and maternal alcohol intake during pregnancy were considered potential confounders.Main outcome measures: Performance on the Wechsler Preschool and Primary Scale of Intelligence-Revised, the TEACh-5, theMABC, and the BRIEF.Results: Intake of 15–21 drinks/week on average prior to pregnancy was not associated with any of the outcomes, but intake of ≥22 drinks/week on average was associated with a significantly lower adjusted mean full scale IQ and lower adjusted means in overall attention and sustained attention score, but not in selective attention score or any of the BRIEF index scores or MABC scores.Conclusions: Intake of ≥22 drinks/week before pregnancy was associated with lower mean full scale IQ, overall attention and sustained attention. Assessment of pre-pregnancy drinking provides additional information regarding potential prenatal alcohol exposure and its implications for child neurodevelopment.
AB - Objective: To examine the effects of pre-pregnancy alcohol drinking on child neuropsychological functioning.Design: Prospective follow-up study.Setting and population: 154 women and their children sampled from the Danish National Birth Cohort.Methods: Participants were sampled based on maternal alcohol consumption before pregnancy. At 5 years of age, the children were tested with the Wechsler Preschool and Primary Scale of Intelligence-Revised, the Test of Everyday Attention for Children atFive (TEACh-5), and the Movement Assessment Battery for Children (MABC). The Behaviour Rating Inventory of Executive Function (BRIEF) was completed by the mothers and a preschool teacher. Parental education, maternal IQ, prenatal maternal smoking, child’s age at testing, child’s sex, and maternal alcohol intake during pregnancy were considered potential confounders.Main outcome measures: Performance on the Wechsler Preschool and Primary Scale of Intelligence-Revised, the TEACh-5, theMABC, and the BRIEF.Results: Intake of 15–21 drinks/week on average prior to pregnancy was not associated with any of the outcomes, but intake of ≥22 drinks/week on average was associated with a significantly lower adjusted mean full scale IQ and lower adjusted means in overall attention and sustained attention score, but not in selective attention score or any of the BRIEF index scores or MABC scores.Conclusions: Intake of ≥22 drinks/week before pregnancy was associated with lower mean full scale IQ, overall attention and sustained attention. Assessment of pre-pregnancy drinking provides additional information regarding potential prenatal alcohol exposure and its implications for child neurodevelopment.
KW - Alcohol drinking
KW - attention
KW - executive function
KW - intelligence
KW - motor function
KW - neurodevelopmental effects
KW - pregnancy
U2 - 10.1111/1471-0528.13172
DO - 10.1111/1471-0528.13172
M3 - Journal article
C2 - 25395365
VL - 122
SP - 1728
EP - 1738
JO - BJOG: An International Journal of Obstetrics and Gynaecology
JF - BJOG: An International Journal of Obstetrics and Gynaecology
SN - 0140-7686
IS - 13
ER -
ID: 160892584