The effect of flexible cognitive-behavioural therapy and medical treatment, including antidepressants on post-traumatic stress disorder and depression in traumatised refugees: pragmatic randomised controlled clinical trial

Research output: Contribution to journalJournal articleResearchpeer-review

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The effect of flexible cognitive-behavioural therapy and medical treatment, including antidepressants on post-traumatic stress disorder and depression in traumatised refugees : pragmatic randomised controlled clinical trial. / Buhmann, Caecilie Böck; Nordentoft, Merete; Ekstrøm, Morten; Lohmann, Jessica Mariana Carlsson; Mortensen, Erik Lykke.

In: British Journal of Psychiatry, Vol. 208, No. 3, 03.2016, p. 252-9.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Buhmann, CB, Nordentoft, M, Ekstrøm, M, Lohmann, JMC & Mortensen, EL 2016, 'The effect of flexible cognitive-behavioural therapy and medical treatment, including antidepressants on post-traumatic stress disorder and depression in traumatised refugees: pragmatic randomised controlled clinical trial', British Journal of Psychiatry, vol. 208, no. 3, pp. 252-9. https://doi.org/10.1192/bjp.bp.114.150961

APA

Buhmann, C. B., Nordentoft, M., Ekstrøm, M., Lohmann, J. M. C., & Mortensen, E. L. (2016). The effect of flexible cognitive-behavioural therapy and medical treatment, including antidepressants on post-traumatic stress disorder and depression in traumatised refugees: pragmatic randomised controlled clinical trial. British Journal of Psychiatry, 208(3), 252-9. https://doi.org/10.1192/bjp.bp.114.150961

Vancouver

Buhmann CB, Nordentoft M, Ekstrøm M, Lohmann JMC, Mortensen EL. The effect of flexible cognitive-behavioural therapy and medical treatment, including antidepressants on post-traumatic stress disorder and depression in traumatised refugees: pragmatic randomised controlled clinical trial. British Journal of Psychiatry. 2016 Mar;208(3):252-9. https://doi.org/10.1192/bjp.bp.114.150961

Author

Buhmann, Caecilie Böck ; Nordentoft, Merete ; Ekstrøm, Morten ; Lohmann, Jessica Mariana Carlsson ; Mortensen, Erik Lykke. / The effect of flexible cognitive-behavioural therapy and medical treatment, including antidepressants on post-traumatic stress disorder and depression in traumatised refugees : pragmatic randomised controlled clinical trial. In: British Journal of Psychiatry. 2016 ; Vol. 208, No. 3. pp. 252-9.

Bibtex

@article{8650b10e20324876bc8c33776c1c6d81,
title = "The effect of flexible cognitive-behavioural therapy and medical treatment, including antidepressants on post-traumatic stress disorder and depression in traumatised refugees: pragmatic randomised controlled clinical trial",
abstract = "BACKGROUND: Little evidence exists on the treatment of traumatised refugees.AIMS: To estimate treatment effects of flexible cognitive-behavioural therapy (CBT) and antidepressants (sertraline and mianserin) in traumatised refugees.METHOD: Randomised controlled clinical trial with 2 × 2 factorial design (registered with Clinicaltrials.gov, NCT00917397, EUDRACT no. 2008-006714-15). Participants were refugees with war-related traumatic experiences, post-traumatic stress disorder (PTSD) and without psychotic disorder. Treatment was weekly sessions with a physician and/or psychologist over 6 months.RESULTS: A total of 217 of 280 patients completed treatment (78%). There was no effect on PTSD symptoms, no effect of psychotherapy and no interaction between psychotherapy and medicine. A small but significant effect of treatment with antidepressants was found on depression.CONCLUSIONS: In a pragmatic clinical setting, there was no effect of flexible CBT and antidepressants on PTSD, and there was a small-to-moderate effect of antidepressants and psychoeducation on depression in traumatised refugees.",
keywords = "Journal Article, Research Support, Non-U.S. Gov't",
author = "Buhmann, {Caecilie B{\"o}ck} and Merete Nordentoft and Morten Ekstr{\o}m and Lohmann, {Jessica Mariana Carlsson} and Mortensen, {Erik Lykke}",
note = "{\textcopyright} The Royal College of Psychiatrists 2016.",
year = "2016",
month = mar,
doi = "10.1192/bjp.bp.114.150961",
language = "English",
volume = "208",
pages = "252--9",
journal = "British Journal of Psychiatry",
issn = "0007-1250",
publisher = "Royal College of Psychiatrists",
number = "3",

}

RIS

TY - JOUR

T1 - The effect of flexible cognitive-behavioural therapy and medical treatment, including antidepressants on post-traumatic stress disorder and depression in traumatised refugees

T2 - pragmatic randomised controlled clinical trial

AU - Buhmann, Caecilie Böck

AU - Nordentoft, Merete

AU - Ekstrøm, Morten

AU - Lohmann, Jessica Mariana Carlsson

AU - Mortensen, Erik Lykke

N1 - © The Royal College of Psychiatrists 2016.

PY - 2016/3

Y1 - 2016/3

N2 - BACKGROUND: Little evidence exists on the treatment of traumatised refugees.AIMS: To estimate treatment effects of flexible cognitive-behavioural therapy (CBT) and antidepressants (sertraline and mianserin) in traumatised refugees.METHOD: Randomised controlled clinical trial with 2 × 2 factorial design (registered with Clinicaltrials.gov, NCT00917397, EUDRACT no. 2008-006714-15). Participants were refugees with war-related traumatic experiences, post-traumatic stress disorder (PTSD) and without psychotic disorder. Treatment was weekly sessions with a physician and/or psychologist over 6 months.RESULTS: A total of 217 of 280 patients completed treatment (78%). There was no effect on PTSD symptoms, no effect of psychotherapy and no interaction between psychotherapy and medicine. A small but significant effect of treatment with antidepressants was found on depression.CONCLUSIONS: In a pragmatic clinical setting, there was no effect of flexible CBT and antidepressants on PTSD, and there was a small-to-moderate effect of antidepressants and psychoeducation on depression in traumatised refugees.

AB - BACKGROUND: Little evidence exists on the treatment of traumatised refugees.AIMS: To estimate treatment effects of flexible cognitive-behavioural therapy (CBT) and antidepressants (sertraline and mianserin) in traumatised refugees.METHOD: Randomised controlled clinical trial with 2 × 2 factorial design (registered with Clinicaltrials.gov, NCT00917397, EUDRACT no. 2008-006714-15). Participants were refugees with war-related traumatic experiences, post-traumatic stress disorder (PTSD) and without psychotic disorder. Treatment was weekly sessions with a physician and/or psychologist over 6 months.RESULTS: A total of 217 of 280 patients completed treatment (78%). There was no effect on PTSD symptoms, no effect of psychotherapy and no interaction between psychotherapy and medicine. A small but significant effect of treatment with antidepressants was found on depression.CONCLUSIONS: In a pragmatic clinical setting, there was no effect of flexible CBT and antidepressants on PTSD, and there was a small-to-moderate effect of antidepressants and psychoeducation on depression in traumatised refugees.

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1192/bjp.bp.114.150961

DO - 10.1192/bjp.bp.114.150961

M3 - Journal article

C2 - 26541687

VL - 208

SP - 252

EP - 259

JO - British Journal of Psychiatry

JF - British Journal of Psychiatry

SN - 0007-1250

IS - 3

ER -

ID: 164455393