Thyroid status and mortality in nonagenarians from long-lived families and the general population

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Thyroid status and mortality in nonagenarians from long-lived families and the general population. / van Vliet, Nicolien A.; van der Spoel, Evie; Beekman, Marian; Slagboom, P. Eline; Blauw, Gerard Jan; Gussekloo, Jacobijn; Westendorp, Rudi G. J.; van Heemst, Diana.

In: Aging, Vol. 9, No. 10, 10.2017, p. 2223—2234.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

van Vliet, NA, van der Spoel, E, Beekman, M, Slagboom, PE, Blauw, GJ, Gussekloo, J, Westendorp, RGJ & van Heemst, D 2017, 'Thyroid status and mortality in nonagenarians from long-lived families and the general population', Aging, vol. 9, no. 10, pp. 2223—2234. https://doi.org/10.18632/aging.101310

APA

van Vliet, N. A., van der Spoel, E., Beekman, M., Slagboom, P. E., Blauw, G. J., Gussekloo, J., ... van Heemst, D. (2017). Thyroid status and mortality in nonagenarians from long-lived families and the general population. Aging, 9(10), 2223—2234. https://doi.org/10.18632/aging.101310

Vancouver

van Vliet NA, van der Spoel E, Beekman M, Slagboom PE, Blauw GJ, Gussekloo J et al. Thyroid status and mortality in nonagenarians from long-lived families and the general population. Aging. 2017 Oct;9(10):2223—2234. https://doi.org/10.18632/aging.101310

Author

van Vliet, Nicolien A. ; van der Spoel, Evie ; Beekman, Marian ; Slagboom, P. Eline ; Blauw, Gerard Jan ; Gussekloo, Jacobijn ; Westendorp, Rudi G. J. ; van Heemst, Diana. / Thyroid status and mortality in nonagenarians from long-lived families and the general population. In: Aging. 2017 ; Vol. 9, No. 10. pp. 2223—2234.

Bibtex

@article{2a010c2c5b4849faac65b8ae1d3c37d2,
title = "Thyroid status and mortality in nonagenarians from long-lived families and the general population",
abstract = "The relationship between thyroid status and longevity has been investigated extensively. However, data on thyroid status and survival in old age is scarce. In this study we investigated associations of different parameters of thyroid status with mortality in nonagenarians, and whether these associations were different in nonagenarians from long-lived families than in nonagenarians from the general population. In total, 805 nonagenarians from the Leiden Longevity Study and 259 nonagenarians from the Leiden 85-plus Study were followed up to collect mortality data. At baseline, levels of thyrotropin (TSH), free thyroxine (fT4) and free triiodothyronine (fT3) were measured. In nonagenarians from long-lived families and from the general population, associations between thyroid parameters and mortality were similar. We found no interaction between study population and parameters of thyroid status on mortality (P-values>0.70). The results from both studies were combined to derive generalizable associations. Hazard ratios (HRs) for the highest compared to lowest tertiles were determined, resulting in TSH HR 0.91 (P=0.25), fT4 HR 1.22 (P=0.02), fT3 HR 0.74 (P=1.31e-4), and fT3/fT4 HR 0.66 (P=5.64e-7). In conclusion, higher fT3/fT4 ratios, higher levels of fT3, and lower levels of fT4 were associated with lower mortality rate in nonagenarians and independent of familial longevity status.",
keywords = "Journal Article",
author = "{van Vliet}, {Nicolien A.} and {van der Spoel}, Evie and Marian Beekman and Slagboom, {P. Eline} and Blauw, {Gerard Jan} and Jacobijn Gussekloo and Westendorp, {Rudi G. J.} and {van Heemst}, Diana",
year = "2017",
month = "10",
doi = "10.18632/aging.101310",
language = "English",
volume = "9",
pages = "2223—2234",
journal = "Aging",
issn = "1945-4589",
publisher = "Impact Journals LLC",
number = "10",

}

RIS

TY - JOUR

T1 - Thyroid status and mortality in nonagenarians from long-lived families and the general population

AU - van Vliet, Nicolien A.

AU - van der Spoel, Evie

AU - Beekman, Marian

AU - Slagboom, P. Eline

AU - Blauw, Gerard Jan

AU - Gussekloo, Jacobijn

AU - Westendorp, Rudi G. J.

AU - van Heemst, Diana

PY - 2017/10

Y1 - 2017/10

N2 - The relationship between thyroid status and longevity has been investigated extensively. However, data on thyroid status and survival in old age is scarce. In this study we investigated associations of different parameters of thyroid status with mortality in nonagenarians, and whether these associations were different in nonagenarians from long-lived families than in nonagenarians from the general population. In total, 805 nonagenarians from the Leiden Longevity Study and 259 nonagenarians from the Leiden 85-plus Study were followed up to collect mortality data. At baseline, levels of thyrotropin (TSH), free thyroxine (fT4) and free triiodothyronine (fT3) were measured. In nonagenarians from long-lived families and from the general population, associations between thyroid parameters and mortality were similar. We found no interaction between study population and parameters of thyroid status on mortality (P-values>0.70). The results from both studies were combined to derive generalizable associations. Hazard ratios (HRs) for the highest compared to lowest tertiles were determined, resulting in TSH HR 0.91 (P=0.25), fT4 HR 1.22 (P=0.02), fT3 HR 0.74 (P=1.31e-4), and fT3/fT4 HR 0.66 (P=5.64e-7). In conclusion, higher fT3/fT4 ratios, higher levels of fT3, and lower levels of fT4 were associated with lower mortality rate in nonagenarians and independent of familial longevity status.

AB - The relationship between thyroid status and longevity has been investigated extensively. However, data on thyroid status and survival in old age is scarce. In this study we investigated associations of different parameters of thyroid status with mortality in nonagenarians, and whether these associations were different in nonagenarians from long-lived families than in nonagenarians from the general population. In total, 805 nonagenarians from the Leiden Longevity Study and 259 nonagenarians from the Leiden 85-plus Study were followed up to collect mortality data. At baseline, levels of thyrotropin (TSH), free thyroxine (fT4) and free triiodothyronine (fT3) were measured. In nonagenarians from long-lived families and from the general population, associations between thyroid parameters and mortality were similar. We found no interaction between study population and parameters of thyroid status on mortality (P-values>0.70). The results from both studies were combined to derive generalizable associations. Hazard ratios (HRs) for the highest compared to lowest tertiles were determined, resulting in TSH HR 0.91 (P=0.25), fT4 HR 1.22 (P=0.02), fT3 HR 0.74 (P=1.31e-4), and fT3/fT4 HR 0.66 (P=5.64e-7). In conclusion, higher fT3/fT4 ratios, higher levels of fT3, and lower levels of fT4 were associated with lower mortality rate in nonagenarians and independent of familial longevity status.

KW - Journal Article

U2 - 10.18632/aging.101310

DO - 10.18632/aging.101310

M3 - Journal article

VL - 9

SP - 2223—2234

JO - Aging

JF - Aging

SN - 1945-4589

IS - 10

ER -

ID: 185192507