Tipping Points-Do the Prognostic Values of Multimorbidity and Functional Status Vary with Age?
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Tipping Points-Do the Prognostic Values of Multimorbidity and Functional Status Vary with Age? / Thygesen, Lau Caspar; Christensen, Kaare; Rorth, Mikael; Sørensen, Henrik Toft; Vandenbroucke, Jan P.; Westendorp, Rudi G. J.
In: Clinical Epidemiology, Vol. 13, 2021, p. 853-857.Research output: Contribution to journal › Editorial › Research › peer-review
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TY - JOUR
T1 - Tipping Points-Do the Prognostic Values of Multimorbidity and Functional Status Vary with Age?
AU - Thygesen, Lau Caspar
AU - Christensen, Kaare
AU - Rorth, Mikael
AU - Sørensen, Henrik Toft
AU - Vandenbroucke, Jan P.
AU - Westendorp, Rudi G. J.
PY - 2021
Y1 - 2021
N2 - Aging of the population is a pressing challenge for healthcare systems and knowledge of a patient's prognosis is a key to shaping effective interventions. As the prevalence of multimorbidity strongly increases with age, the prognostic value of multiple disease diagnoses for survival among older people may diminish, whereas other measures of health, such as functional status (defined as a measure of an individual's ability to perform activities of daily living), may become more important. In this commentary, the impact of age on the prognostic value of multimorbidity is discussed, with the aim of identifying relevant alternative risk indicators for different age groups. The key question is to determine at what age the prognostic value of multimorbidity for meaningful clinical outcomes decreases and is overridden by the prognostic value of functional status. This tipping point likely depends on age, calendar time, and birth cohort. The public health and clinical implications of these tipping points are important. Among younger and middle-aged persons, interventions could be directed towards prevention and treatment of specific diseases, while among older persons efforts should focus more on improving functional levels that include physical, emotional, and social dimensions.
AB - Aging of the population is a pressing challenge for healthcare systems and knowledge of a patient's prognosis is a key to shaping effective interventions. As the prevalence of multimorbidity strongly increases with age, the prognostic value of multiple disease diagnoses for survival among older people may diminish, whereas other measures of health, such as functional status (defined as a measure of an individual's ability to perform activities of daily living), may become more important. In this commentary, the impact of age on the prognostic value of multimorbidity is discussed, with the aim of identifying relevant alternative risk indicators for different age groups. The key question is to determine at what age the prognostic value of multimorbidity for meaningful clinical outcomes decreases and is overridden by the prognostic value of functional status. This tipping point likely depends on age, calendar time, and birth cohort. The public health and clinical implications of these tipping points are important. Among younger and middle-aged persons, interventions could be directed towards prevention and treatment of specific diseases, while among older persons efforts should focus more on improving functional levels that include physical, emotional, and social dimensions.
KW - chronic disease
KW - health services
KW - public health
KW - aged
KW - multimorbidity
KW - OLDER-ADULTS
KW - HEALTH
KW - COMORBIDITY
KW - FRAILTY
KW - TIME
KW - PREVALENCE
KW - MORTALITY
KW - DEMENTIA
KW - QUALITY
KW - TRENDS
U2 - 10.2147/CLEP.S325348
DO - 10.2147/CLEP.S325348
M3 - Editorial
C2 - 34588816
VL - 13
SP - 853
EP - 857
JO - Clinical Epidemiology
JF - Clinical Epidemiology
SN - 1179-1349
ER -
ID: 281701439