Trait aggression and trait impulsivity are not related to frontal cortex 5-HT2A receptor binding in healthy individuals

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Trait aggression and trait impulsivity are not related to frontal cortex 5-HT2A receptor binding in healthy individuals. / da Cunha-Bang, Sophie; Stenbæk, Dea Siggaard; Holst, Klaus; Licht, Cecilie Löe; Jensen, Peter Steen; Frokjaer, Vibe Gedsø; Mortensen, Erik Lykke; Knudsen, Gitte Moos.

In: Psychiatry Research, Vol. 212, No. 2, 2013, p. 125-131.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

da Cunha-Bang, S, Stenbæk, DS, Holst, K, Licht, CL, Jensen, PS, Frokjaer, VG, Mortensen, EL & Knudsen, GM 2013, 'Trait aggression and trait impulsivity are not related to frontal cortex 5-HT2A receptor binding in healthy individuals', Psychiatry Research, vol. 212, no. 2, pp. 125-131. https://doi.org/10.1016/j.pscychresns.2012.09.007

APA

da Cunha-Bang, S., Stenbæk, D. S., Holst, K., Licht, C. L., Jensen, P. S., Frokjaer, V. G., ... Knudsen, G. M. (2013). Trait aggression and trait impulsivity are not related to frontal cortex 5-HT2A receptor binding in healthy individuals. Psychiatry Research, 212(2), 125-131. https://doi.org/10.1016/j.pscychresns.2012.09.007

Vancouver

da Cunha-Bang S, Stenbæk DS, Holst K, Licht CL, Jensen PS, Frokjaer VG et al. Trait aggression and trait impulsivity are not related to frontal cortex 5-HT2A receptor binding in healthy individuals. Psychiatry Research. 2013;212(2):125-131. https://doi.org/10.1016/j.pscychresns.2012.09.007

Author

da Cunha-Bang, Sophie ; Stenbæk, Dea Siggaard ; Holst, Klaus ; Licht, Cecilie Löe ; Jensen, Peter Steen ; Frokjaer, Vibe Gedsø ; Mortensen, Erik Lykke ; Knudsen, Gitte Moos. / Trait aggression and trait impulsivity are not related to frontal cortex 5-HT2A receptor binding in healthy individuals. In: Psychiatry Research. 2013 ; Vol. 212, No. 2. pp. 125-131.

Bibtex

@article{f1d925fcd880480084601363a867d792,
title = "Trait aggression and trait impulsivity are not related to frontal cortex 5-HT2A receptor binding in healthy individuals",
abstract = "Numerous studies indicate that the serotonergic (5-HT) transmitter system is involved in the regulation of impulsive aggression and there is from post-mortem, in vivo imaging and genetic studies evidence that the 5-HT2A receptor may be involved. We investigated 94 healthy individuals (60 men, mean age 47.0±18.7, range 23-86) to determine if trait aggression and trait impulsivity were related to frontal cortex 5-HT2A receptor binding (5-HT2AR) as measured with [(18)F]-altanserin PET imaging. Trait aggression and trait impulsivity were assessed with the Buss-Perry Aggression Questionnaire (AQ) and the Barratt Impulsiveness Scale 11 (BIS-11). Statistical analyses were conducted using a multiple linear regression model and internal consistency reliability of the AQ and BIS-11 was evaluated by Cronbach's alpha. Contrary to our hypothesis, results revealed no significant associations between 5-HT2AR and the AQ or BIS-11 total scores. Also, there was no significant interaction between gender and frontal cortex 5-HT2AR in predicting trait aggression and trait impulsivity. This is the first study to examine how 5-HT2AR relates to trait aggression and trait impulsivity in a large sample of healthy individuals. Our findings are not supportive of a selective role for 5-HT2AR in mediating the 5-HT related effects on aggression and impulsivity in psychiatrically healthy individuals.",
keywords = "Aggression, Impulsivity, Positron Emission Tomography (PET), Serotonin",
author = "{da Cunha-Bang}, Sophie and Stenb{\ae}k, {Dea Siggaard} and Klaus Holst and Licht, {Cecilie L{\"o}e} and Jensen, {Peter Steen} and Frokjaer, {Vibe Geds{\o}} and Mortensen, {Erik Lykke} and Knudsen, {Gitte Moos}",
note = "Copyright {\circledC} 2012 Elsevier Ireland Ltd. All rights reserved.",
year = "2013",
doi = "10.1016/j.pscychresns.2012.09.007",
language = "English",
volume = "212",
pages = "125--131",
journal = "Psychiatry Research",
issn = "0165-1781",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

RIS

TY - JOUR

T1 - Trait aggression and trait impulsivity are not related to frontal cortex 5-HT2A receptor binding in healthy individuals

AU - da Cunha-Bang, Sophie

AU - Stenbæk, Dea Siggaard

AU - Holst, Klaus

AU - Licht, Cecilie Löe

AU - Jensen, Peter Steen

AU - Frokjaer, Vibe Gedsø

AU - Mortensen, Erik Lykke

AU - Knudsen, Gitte Moos

N1 - Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

PY - 2013

Y1 - 2013

N2 - Numerous studies indicate that the serotonergic (5-HT) transmitter system is involved in the regulation of impulsive aggression and there is from post-mortem, in vivo imaging and genetic studies evidence that the 5-HT2A receptor may be involved. We investigated 94 healthy individuals (60 men, mean age 47.0±18.7, range 23-86) to determine if trait aggression and trait impulsivity were related to frontal cortex 5-HT2A receptor binding (5-HT2AR) as measured with [(18)F]-altanserin PET imaging. Trait aggression and trait impulsivity were assessed with the Buss-Perry Aggression Questionnaire (AQ) and the Barratt Impulsiveness Scale 11 (BIS-11). Statistical analyses were conducted using a multiple linear regression model and internal consistency reliability of the AQ and BIS-11 was evaluated by Cronbach's alpha. Contrary to our hypothesis, results revealed no significant associations between 5-HT2AR and the AQ or BIS-11 total scores. Also, there was no significant interaction between gender and frontal cortex 5-HT2AR in predicting trait aggression and trait impulsivity. This is the first study to examine how 5-HT2AR relates to trait aggression and trait impulsivity in a large sample of healthy individuals. Our findings are not supportive of a selective role for 5-HT2AR in mediating the 5-HT related effects on aggression and impulsivity in psychiatrically healthy individuals.

AB - Numerous studies indicate that the serotonergic (5-HT) transmitter system is involved in the regulation of impulsive aggression and there is from post-mortem, in vivo imaging and genetic studies evidence that the 5-HT2A receptor may be involved. We investigated 94 healthy individuals (60 men, mean age 47.0±18.7, range 23-86) to determine if trait aggression and trait impulsivity were related to frontal cortex 5-HT2A receptor binding (5-HT2AR) as measured with [(18)F]-altanserin PET imaging. Trait aggression and trait impulsivity were assessed with the Buss-Perry Aggression Questionnaire (AQ) and the Barratt Impulsiveness Scale 11 (BIS-11). Statistical analyses were conducted using a multiple linear regression model and internal consistency reliability of the AQ and BIS-11 was evaluated by Cronbach's alpha. Contrary to our hypothesis, results revealed no significant associations between 5-HT2AR and the AQ or BIS-11 total scores. Also, there was no significant interaction between gender and frontal cortex 5-HT2AR in predicting trait aggression and trait impulsivity. This is the first study to examine how 5-HT2AR relates to trait aggression and trait impulsivity in a large sample of healthy individuals. Our findings are not supportive of a selective role for 5-HT2AR in mediating the 5-HT related effects on aggression and impulsivity in psychiatrically healthy individuals.

KW - Aggression

KW - Impulsivity

KW - Positron Emission Tomography (PET)

KW - Serotonin

U2 - 10.1016/j.pscychresns.2012.09.007

DO - 10.1016/j.pscychresns.2012.09.007

M3 - Journal article

C2 - 23137806

VL - 212

SP - 125

EP - 131

JO - Psychiatry Research

JF - Psychiatry Research

SN - 0165-1781

IS - 2

ER -

ID: 118042826