Transmission of intelligence, working memory, and processing speed from parents to their seven-year-old offspring is function specific in families with schizophrenia or bipolar disorder

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Transmission of intelligence, working memory, and processing speed from parents to their seven-year-old offspring is function specific in families with schizophrenia or bipolar disorder. / Greve, Aja Neergaard; Jepsen, Jens Richardt Møllegaard; Mortensen, Erik Lykke; Uher, Rudolf; Mackenzie, Lynn; Foldager, Leslie; Gantriis, Ditte; Burton, Birgitte Klee; Ellersgaard, Ditte; Christiani, Camilla Jerlang; Spang, Katrine S.; Hemager, Nicoline; Uddin, Jamal; Henriksen, Maria Toft; Zahle, Kate Kold; Stadsgaard, Henriette; Plessen, Kerstin J.; Thorup, Anne A. E.; Nordentoft, Merete; Mors, Ole; Bliksted, Vibeke.

In: Schizophrenia Research, Vol. 246, 2022, p. 195-201.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Greve, AN, Jepsen, JRM, Mortensen, EL, Uher, R, Mackenzie, L, Foldager, L, Gantriis, D, Burton, BK, Ellersgaard, D, Christiani, CJ, Spang, KS, Hemager, N, Uddin, J, Henriksen, MT, Zahle, KK, Stadsgaard, H, Plessen, KJ, Thorup, AAE, Nordentoft, M, Mors, O & Bliksted, V 2022, 'Transmission of intelligence, working memory, and processing speed from parents to their seven-year-old offspring is function specific in families with schizophrenia or bipolar disorder', Schizophrenia Research, vol. 246, pp. 195-201. https://doi.org/10.1016/j.schres.2022.06.032

APA

Greve, A. N., Jepsen, J. R. M., Mortensen, E. L., Uher, R., Mackenzie, L., Foldager, L., Gantriis, D., Burton, B. K., Ellersgaard, D., Christiani, C. J., Spang, K. S., Hemager, N., Uddin, J., Henriksen, M. T., Zahle, K. K., Stadsgaard, H., Plessen, K. J., Thorup, A. A. E., Nordentoft, M., ... Bliksted, V. (2022). Transmission of intelligence, working memory, and processing speed from parents to their seven-year-old offspring is function specific in families with schizophrenia or bipolar disorder. Schizophrenia Research, 246, 195-201. https://doi.org/10.1016/j.schres.2022.06.032

Vancouver

Greve AN, Jepsen JRM, Mortensen EL, Uher R, Mackenzie L, Foldager L et al. Transmission of intelligence, working memory, and processing speed from parents to their seven-year-old offspring is function specific in families with schizophrenia or bipolar disorder. Schizophrenia Research. 2022;246:195-201. https://doi.org/10.1016/j.schres.2022.06.032

Author

Greve, Aja Neergaard ; Jepsen, Jens Richardt Møllegaard ; Mortensen, Erik Lykke ; Uher, Rudolf ; Mackenzie, Lynn ; Foldager, Leslie ; Gantriis, Ditte ; Burton, Birgitte Klee ; Ellersgaard, Ditte ; Christiani, Camilla Jerlang ; Spang, Katrine S. ; Hemager, Nicoline ; Uddin, Jamal ; Henriksen, Maria Toft ; Zahle, Kate Kold ; Stadsgaard, Henriette ; Plessen, Kerstin J. ; Thorup, Anne A. E. ; Nordentoft, Merete ; Mors, Ole ; Bliksted, Vibeke. / Transmission of intelligence, working memory, and processing speed from parents to their seven-year-old offspring is function specific in families with schizophrenia or bipolar disorder. In: Schizophrenia Research. 2022 ; Vol. 246. pp. 195-201.

Bibtex

@article{b4e4c37f34b742a3a322eba399a212a9,
title = "Transmission of intelligence, working memory, and processing speed from parents to their seven-year-old offspring is function specific in families with schizophrenia or bipolar disorder",
abstract = "Background: Prior studies have shown high heritability estimates regarding within-function transmission of neurocognition, both in healthy families and in families with schizophrenia but it remains an open question whether transmission from parents to offspring is function specific and whether the pattern is the same in healthy families and families with schizophrenia or bipolar disorder. We aimed to characterize the transmission of intelligence, processing speed, and verbal working memory functions from both biological parents to their 7-year old offspring in families with parental schizophrenia, bipolar disorder, and population-based control parents. Methods: The population-based cohort consists of 7-year-old children with one parent diagnosed with schizophrenia (n = 186), bipolar disorder (n = 114), and of parents without schizophrenia or bipolar disorder (n = 192). Children and both parents were assessed using identical, age-relevant neurocognitive tests of intelligence, verbal working memory, and processing speed. Results: In multiple regression analyses children's intelligence, verbal working memory, and processing speed scores were significantly associated with the corresponding parental cognitive function score. All associations from parents to offspring across functions were non-significant. No significant parental cognitive function by group interaction was observed. Conclusion: Transmissions of intelligence, processing speed, and verbal working memory from parents to offspring are function specific. The structure of transmission is comparable between families with schizophrenia, families with bipolar disorder and families without these disorders.",
keywords = "Familial high risk, Neurocognition, Transgenerational transmission, Heritability, DANISH HIGH-RISK, COGNITIVE DEFICITS, FLUID INTELLIGENCE, METAANALYSIS, ENDOPHENOTYPES, RESILIENCE, CHILDREN, COHORT",
author = "Greve, {Aja Neergaard} and Jepsen, {Jens Richardt M{\o}llegaard} and Mortensen, {Erik Lykke} and Rudolf Uher and Lynn Mackenzie and Leslie Foldager and Ditte Gantriis and Burton, {Birgitte Klee} and Ditte Ellersgaard and Christiani, {Camilla Jerlang} and Spang, {Katrine S.} and Nicoline Hemager and Jamal Uddin and Henriksen, {Maria Toft} and Zahle, {Kate Kold} and Henriette Stadsgaard and Plessen, {Kerstin J.} and Thorup, {Anne A. E.} and Merete Nordentoft and Ole Mors and Vibeke Bliksted",
year = "2022",
doi = "10.1016/j.schres.2022.06.032",
language = "English",
volume = "246",
pages = "195--201",
journal = "Schizophrenia Research",
issn = "0920-9964",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Transmission of intelligence, working memory, and processing speed from parents to their seven-year-old offspring is function specific in families with schizophrenia or bipolar disorder

AU - Greve, Aja Neergaard

AU - Jepsen, Jens Richardt Møllegaard

AU - Mortensen, Erik Lykke

AU - Uher, Rudolf

AU - Mackenzie, Lynn

AU - Foldager, Leslie

AU - Gantriis, Ditte

AU - Burton, Birgitte Klee

AU - Ellersgaard, Ditte

AU - Christiani, Camilla Jerlang

AU - Spang, Katrine S.

AU - Hemager, Nicoline

AU - Uddin, Jamal

AU - Henriksen, Maria Toft

AU - Zahle, Kate Kold

AU - Stadsgaard, Henriette

AU - Plessen, Kerstin J.

AU - Thorup, Anne A. E.

AU - Nordentoft, Merete

AU - Mors, Ole

AU - Bliksted, Vibeke

PY - 2022

Y1 - 2022

N2 - Background: Prior studies have shown high heritability estimates regarding within-function transmission of neurocognition, both in healthy families and in families with schizophrenia but it remains an open question whether transmission from parents to offspring is function specific and whether the pattern is the same in healthy families and families with schizophrenia or bipolar disorder. We aimed to characterize the transmission of intelligence, processing speed, and verbal working memory functions from both biological parents to their 7-year old offspring in families with parental schizophrenia, bipolar disorder, and population-based control parents. Methods: The population-based cohort consists of 7-year-old children with one parent diagnosed with schizophrenia (n = 186), bipolar disorder (n = 114), and of parents without schizophrenia or bipolar disorder (n = 192). Children and both parents were assessed using identical, age-relevant neurocognitive tests of intelligence, verbal working memory, and processing speed. Results: In multiple regression analyses children's intelligence, verbal working memory, and processing speed scores were significantly associated with the corresponding parental cognitive function score. All associations from parents to offspring across functions were non-significant. No significant parental cognitive function by group interaction was observed. Conclusion: Transmissions of intelligence, processing speed, and verbal working memory from parents to offspring are function specific. The structure of transmission is comparable between families with schizophrenia, families with bipolar disorder and families without these disorders.

AB - Background: Prior studies have shown high heritability estimates regarding within-function transmission of neurocognition, both in healthy families and in families with schizophrenia but it remains an open question whether transmission from parents to offspring is function specific and whether the pattern is the same in healthy families and families with schizophrenia or bipolar disorder. We aimed to characterize the transmission of intelligence, processing speed, and verbal working memory functions from both biological parents to their 7-year old offspring in families with parental schizophrenia, bipolar disorder, and population-based control parents. Methods: The population-based cohort consists of 7-year-old children with one parent diagnosed with schizophrenia (n = 186), bipolar disorder (n = 114), and of parents without schizophrenia or bipolar disorder (n = 192). Children and both parents were assessed using identical, age-relevant neurocognitive tests of intelligence, verbal working memory, and processing speed. Results: In multiple regression analyses children's intelligence, verbal working memory, and processing speed scores were significantly associated with the corresponding parental cognitive function score. All associations from parents to offspring across functions were non-significant. No significant parental cognitive function by group interaction was observed. Conclusion: Transmissions of intelligence, processing speed, and verbal working memory from parents to offspring are function specific. The structure of transmission is comparable between families with schizophrenia, families with bipolar disorder and families without these disorders.

KW - Familial high risk

KW - Neurocognition

KW - Transgenerational transmission

KW - Heritability

KW - DANISH HIGH-RISK

KW - COGNITIVE DEFICITS

KW - FLUID INTELLIGENCE

KW - METAANALYSIS

KW - ENDOPHENOTYPES

KW - RESILIENCE

KW - CHILDREN

KW - COHORT

U2 - 10.1016/j.schres.2022.06.032

DO - 10.1016/j.schres.2022.06.032

M3 - Journal article

C2 - 35802954

VL - 246

SP - 195

EP - 201

JO - Schizophrenia Research

JF - Schizophrenia Research

SN - 0920-9964

ER -

ID: 314896065