Uncarboxylated matrix Gla-protein: A biomarker of vitamin K status and cardiovascular risk

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Uncarboxylated matrix Gla-protein : A biomarker of vitamin K status and cardiovascular risk. / Jespersen, T.; Møllehave, L. T.; Thuesen, B. H.; Skaaby, T.; Rossing, P.; Toft, U.; Jørgensen, N. R.; Corfixen, B. L.; Jakobsen, J.; Frimodt-Møller, M.; Linneberg, A.

In: Clinical Biochemistry, Vol. 83, 2020, p. 49-56.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Jespersen, T, Møllehave, LT, Thuesen, BH, Skaaby, T, Rossing, P, Toft, U, Jørgensen, NR, Corfixen, BL, Jakobsen, J, Frimodt-Møller, M & Linneberg, A 2020, 'Uncarboxylated matrix Gla-protein: A biomarker of vitamin K status and cardiovascular risk', Clinical Biochemistry, vol. 83, pp. 49-56. https://doi.org/10.1016/j.clinbiochem.2020.05.005

APA

Jespersen, T., Møllehave, L. T., Thuesen, B. H., Skaaby, T., Rossing, P., Toft, U., Jørgensen, N. R., Corfixen, B. L., Jakobsen, J., Frimodt-Møller, M., & Linneberg, A. (2020). Uncarboxylated matrix Gla-protein: A biomarker of vitamin K status and cardiovascular risk. Clinical Biochemistry, 83, 49-56. https://doi.org/10.1016/j.clinbiochem.2020.05.005

Vancouver

Jespersen T, Møllehave LT, Thuesen BH, Skaaby T, Rossing P, Toft U et al. Uncarboxylated matrix Gla-protein: A biomarker of vitamin K status and cardiovascular risk. Clinical Biochemistry. 2020;83:49-56. https://doi.org/10.1016/j.clinbiochem.2020.05.005

Author

Jespersen, T. ; Møllehave, L. T. ; Thuesen, B. H. ; Skaaby, T. ; Rossing, P. ; Toft, U. ; Jørgensen, N. R. ; Corfixen, B. L. ; Jakobsen, J. ; Frimodt-Møller, M. ; Linneberg, A. / Uncarboxylated matrix Gla-protein : A biomarker of vitamin K status and cardiovascular risk. In: Clinical Biochemistry. 2020 ; Vol. 83. pp. 49-56.

Bibtex

@article{157b5e93a5a54dfaa2e7101d7b5f0981,
title = "Uncarboxylated matrix Gla-protein: A biomarker of vitamin K status and cardiovascular risk",
abstract = "Background: Dephosphorylated uncarboxylated matrix Gla-protein (dp-ucMGP) is a biomarker of functional vitamin K status. High plasma dp-ucMGP concentrations reflect a low vitamin K status and have been related to vascular calcification. Our aims were to assess plasma levels of dp-ucMGP and their association with cardiovascular risk in a general population. Methods: Plasma dp-ucMGP measurements were performed using the IDS-iSYS InaKtif MGP assay in 491 consecutive participants in a Danish general population study (229 males and 262 females, aged 19–71 years). Multivariable linear and logistic regressions were used to assess the association between dp-ucMGP levels and cardiovascular risk factors. Results: Mean ± standard deviation (SD) for dp-ucMGP was 465 ± 181 pmol/L, and upper 95th percentile was 690 pmol/L. In logistic regression analyses, an increase in dp-ucMGP category (<300, 300–399, 400–499, ≥500 pmol/L) was positively associated with obesity, odds ratio (OR) 2.27 (95% confidence interval (CI) 1.54–3.33), history of cardiovascular disease, OR 1.77 (CI 1.02–3.05), and above-median estimated pulse wave velocity (ePWV), OR 1.54 (CI 1.21–1.96), when adjusted for age, sex, and lifestyle factors. 1 SD increase in diastolic and systolic blood pressure (BP) corresponded to a 5.5% (CI 2.9–8.0%) and 4.7% (CI 2.1–7.4%) increase in dp-ucMGP, respectively, when adjusted for age and sex. Conclusion: Plasma dp-ucMGP levels were positively associated with obesity, BP, ePWV, and history of cardiovascular disease. These findings support that dp-ucMGP is a biomarker of cardiovascular risk, and that vitamin K status could play a role in vascular calcification. The strong association with obesity deserves further attention.",
keywords = "Cardiovascular risk, dp-ucMGP, Matrix Gla protein, Vitamin K",
author = "T. Jespersen and M{\o}llehave, {L. T.} and Thuesen, {B. H.} and T. Skaaby and P. Rossing and U. Toft and J{\o}rgensen, {N. R.} and Corfixen, {B. L.} and J. Jakobsen and M. Frimodt-M{\o}ller and A. Linneberg",
year = "2020",
doi = "10.1016/j.clinbiochem.2020.05.005",
language = "English",
volume = "83",
pages = "49--56",
journal = "Clinical Biochemistry",
issn = "0009-9120",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Uncarboxylated matrix Gla-protein

T2 - A biomarker of vitamin K status and cardiovascular risk

AU - Jespersen, T.

AU - Møllehave, L. T.

AU - Thuesen, B. H.

AU - Skaaby, T.

AU - Rossing, P.

AU - Toft, U.

AU - Jørgensen, N. R.

AU - Corfixen, B. L.

AU - Jakobsen, J.

AU - Frimodt-Møller, M.

AU - Linneberg, A.

PY - 2020

Y1 - 2020

N2 - Background: Dephosphorylated uncarboxylated matrix Gla-protein (dp-ucMGP) is a biomarker of functional vitamin K status. High plasma dp-ucMGP concentrations reflect a low vitamin K status and have been related to vascular calcification. Our aims were to assess plasma levels of dp-ucMGP and their association with cardiovascular risk in a general population. Methods: Plasma dp-ucMGP measurements were performed using the IDS-iSYS InaKtif MGP assay in 491 consecutive participants in a Danish general population study (229 males and 262 females, aged 19–71 years). Multivariable linear and logistic regressions were used to assess the association between dp-ucMGP levels and cardiovascular risk factors. Results: Mean ± standard deviation (SD) for dp-ucMGP was 465 ± 181 pmol/L, and upper 95th percentile was 690 pmol/L. In logistic regression analyses, an increase in dp-ucMGP category (<300, 300–399, 400–499, ≥500 pmol/L) was positively associated with obesity, odds ratio (OR) 2.27 (95% confidence interval (CI) 1.54–3.33), history of cardiovascular disease, OR 1.77 (CI 1.02–3.05), and above-median estimated pulse wave velocity (ePWV), OR 1.54 (CI 1.21–1.96), when adjusted for age, sex, and lifestyle factors. 1 SD increase in diastolic and systolic blood pressure (BP) corresponded to a 5.5% (CI 2.9–8.0%) and 4.7% (CI 2.1–7.4%) increase in dp-ucMGP, respectively, when adjusted for age and sex. Conclusion: Plasma dp-ucMGP levels were positively associated with obesity, BP, ePWV, and history of cardiovascular disease. These findings support that dp-ucMGP is a biomarker of cardiovascular risk, and that vitamin K status could play a role in vascular calcification. The strong association with obesity deserves further attention.

AB - Background: Dephosphorylated uncarboxylated matrix Gla-protein (dp-ucMGP) is a biomarker of functional vitamin K status. High plasma dp-ucMGP concentrations reflect a low vitamin K status and have been related to vascular calcification. Our aims were to assess plasma levels of dp-ucMGP and their association with cardiovascular risk in a general population. Methods: Plasma dp-ucMGP measurements were performed using the IDS-iSYS InaKtif MGP assay in 491 consecutive participants in a Danish general population study (229 males and 262 females, aged 19–71 years). Multivariable linear and logistic regressions were used to assess the association between dp-ucMGP levels and cardiovascular risk factors. Results: Mean ± standard deviation (SD) for dp-ucMGP was 465 ± 181 pmol/L, and upper 95th percentile was 690 pmol/L. In logistic regression analyses, an increase in dp-ucMGP category (<300, 300–399, 400–499, ≥500 pmol/L) was positively associated with obesity, odds ratio (OR) 2.27 (95% confidence interval (CI) 1.54–3.33), history of cardiovascular disease, OR 1.77 (CI 1.02–3.05), and above-median estimated pulse wave velocity (ePWV), OR 1.54 (CI 1.21–1.96), when adjusted for age, sex, and lifestyle factors. 1 SD increase in diastolic and systolic blood pressure (BP) corresponded to a 5.5% (CI 2.9–8.0%) and 4.7% (CI 2.1–7.4%) increase in dp-ucMGP, respectively, when adjusted for age and sex. Conclusion: Plasma dp-ucMGP levels were positively associated with obesity, BP, ePWV, and history of cardiovascular disease. These findings support that dp-ucMGP is a biomarker of cardiovascular risk, and that vitamin K status could play a role in vascular calcification. The strong association with obesity deserves further attention.

KW - Cardiovascular risk

KW - dp-ucMGP

KW - Matrix Gla protein

KW - Vitamin K

U2 - 10.1016/j.clinbiochem.2020.05.005

DO - 10.1016/j.clinbiochem.2020.05.005

M3 - Journal article

C2 - 32422228

AN - SCOPUS:85087039010

VL - 83

SP - 49

EP - 56

JO - Clinical Biochemistry

JF - Clinical Biochemistry

SN - 0009-9120

ER -

ID: 250548589