Urinary excretion of 8-oxo-7,8-dihydroguanine as biomarker of oxidative damage to DNA
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Urinary excretion of 8-oxo-7,8-dihydroguanine as biomarker of oxidative damage to DNA. / Loft, Steffen; Danielsen, Pernille Høgh; Løhr, Mille; Jantzen, Kim; Hemmingsen, Jette G; Roursgaard, Martin; Karottki, Dorina Gabriela; Møller, Peter.
In: Archives of Biochemistry and Biophysics, Vol. 518, No. 2, 2012, p. 142-50.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Urinary excretion of 8-oxo-7,8-dihydroguanine as biomarker of oxidative damage to DNA
AU - Loft, Steffen
AU - Danielsen, Pernille Høgh
AU - Løhr, Mille
AU - Jantzen, Kim
AU - Hemmingsen, Jette G
AU - Roursgaard, Martin
AU - Karottki, Dorina Gabriela
AU - Møller, Peter
N1 - Copyright © 2012 Elsevier Inc. All rights reserved.
PY - 2012
Y1 - 2012
N2 - Oxidatively damaged DNA may be important in carcinogenesis. 8-Oxo-7,8-dihydroguanine (8-oxoGua) is an abundant and mutagenic lesion excised by oxoguanine DNA glycosylase 1 (OGG1) and measurable in urine or plasma by chromatographic methods with electrochemical or mass spectrometric detectors, reflecting the rate of damage in steady state. A common genetic OGG1 variant may affect the activity and was associated with increased levels of oxidized purines in leukocytes without apparent effect on 8-oxoGua excretion or major change in cancer risk. 8-OxoGua excretion has been associated with exposure to air pollution, toxic metals, tobacco smoke and low plasma antioxidant levels, whereas fruit and vegetable intake or dietary interventions showed no association. In rodent studies some types of feed may be source of 8-oxoGua in collected urine. Of cancer therapies, cisplatin increased 8-oxoGua excretion, whereas radiotherapy only showed such effects in experimental animals. Case-control studies found high excretion of 8-oxoGua in relation to cancer, dementia and celiac disease but not hemochromatosis, although associations could be a consequence rather than reflecting causality of disease. One prospective study found increased risk of developing lung cancer among non-smokers associated with high excretion of 8-oxoGua. Urinary excretion of 8-oxoGua is a promising biomarker of oxidatively damaged DNA.
AB - Oxidatively damaged DNA may be important in carcinogenesis. 8-Oxo-7,8-dihydroguanine (8-oxoGua) is an abundant and mutagenic lesion excised by oxoguanine DNA glycosylase 1 (OGG1) and measurable in urine or plasma by chromatographic methods with electrochemical or mass spectrometric detectors, reflecting the rate of damage in steady state. A common genetic OGG1 variant may affect the activity and was associated with increased levels of oxidized purines in leukocytes without apparent effect on 8-oxoGua excretion or major change in cancer risk. 8-OxoGua excretion has been associated with exposure to air pollution, toxic metals, tobacco smoke and low plasma antioxidant levels, whereas fruit and vegetable intake or dietary interventions showed no association. In rodent studies some types of feed may be source of 8-oxoGua in collected urine. Of cancer therapies, cisplatin increased 8-oxoGua excretion, whereas radiotherapy only showed such effects in experimental animals. Case-control studies found high excretion of 8-oxoGua in relation to cancer, dementia and celiac disease but not hemochromatosis, although associations could be a consequence rather than reflecting causality of disease. One prospective study found increased risk of developing lung cancer among non-smokers associated with high excretion of 8-oxoGua. Urinary excretion of 8-oxoGua is a promising biomarker of oxidatively damaged DNA.
U2 - 10.1016/j.abb.2011.12.026
DO - 10.1016/j.abb.2011.12.026
M3 - Journal article
C2 - 22239988
VL - 518
SP - 142
EP - 150
JO - Archives of Biochemistry and Biophysics
JF - Archives of Biochemistry and Biophysics
SN - 0003-9861
IS - 2
ER -
ID: 37550520