Use of nicotine replacement therapy during pregnancy and stillbirth: a cohort study

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Standard

Use of nicotine replacement therapy during pregnancy and stillbirth : a cohort study. / Strandberg-Larsen, K; Tinggaard, M; Andersen, Anne-Marie Nybo; Olsen, J; Grønbaek, M.

In: British Journal of Obstetrics and Gynecology, Vol. 115, No. 11, 2008, p. 1405-10.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Strandberg-Larsen, K, Tinggaard, M, Andersen, A-MN, Olsen, J & Grønbaek, M 2008, 'Use of nicotine replacement therapy during pregnancy and stillbirth: a cohort study', British Journal of Obstetrics and Gynecology, vol. 115, no. 11, pp. 1405-10. https://doi.org/10.1111/j.1471-0528.2008.01867.x

APA

Strandberg-Larsen, K., Tinggaard, M., Andersen, A-M. N., Olsen, J., & Grønbaek, M. (2008). Use of nicotine replacement therapy during pregnancy and stillbirth: a cohort study. British Journal of Obstetrics and Gynecology, 115(11), 1405-10. https://doi.org/10.1111/j.1471-0528.2008.01867.x

Vancouver

Strandberg-Larsen K, Tinggaard M, Andersen A-MN, Olsen J, Grønbaek M. Use of nicotine replacement therapy during pregnancy and stillbirth: a cohort study. British Journal of Obstetrics and Gynecology. 2008;115(11):1405-10. https://doi.org/10.1111/j.1471-0528.2008.01867.x

Author

Strandberg-Larsen, K ; Tinggaard, M ; Andersen, Anne-Marie Nybo ; Olsen, J ; Grønbaek, M. / Use of nicotine replacement therapy during pregnancy and stillbirth : a cohort study. In: British Journal of Obstetrics and Gynecology. 2008 ; Vol. 115, No. 11. pp. 1405-10.

Bibtex

@article{24b608109f0011df928f000ea68e967b,
title = "Use of nicotine replacement therapy during pregnancy and stillbirth: a cohort study",
abstract = "OBJECTIVE: The objective of this study was to examine whether the use of nicotine replacement therapy (NRT) during pregnancy increases the risk of stillbirth. DESIGN: Cohort study with prospective data. SETTING: Denmark 1996-2002. POPULATION: A total of 87,032 singleton pregnancies enrolled in the Danish National Birth Cohort for which information on NRT use as well as smoking was available. METHODS: Outcome of pregnancy was identified by register linkage, with <1{\%} loss to follow up. We conducted Cox regression analyses to estimate the hazard ratio (HR) and 95{\%} CI of stillbirth according to the use of NRT, type of NRT use and a combination of NRT use and smoking. MAIN OUTCOME MEASURES: Stillbirth, defined as delivery of a dead fetus after 20 completed weeks of gestation. RESULTS: A total of 495 pregnancies (5.7 in 1000 births) ended in stillbirth, 8 of which were among NRT users (4.2 in 1000 births). After adjustment for confounders, women who used NRT during pregnancy had a HR of 0.57 (95{\%} CI 0.28-1.16) for stillbirth compared with those who did not use NRT. Smoking during pregnancy was associated with an increased risk of stillbirth (HR 1.46, 95{\%} CI 1.17-1.82), while women who both smoked and used NRT had a HR of 0.83 (95{\%} CI 0.34-2.00) compared with nonsmoking women who did not use NRT. CONCLUSION: Our study does not indicate that use of NRT during pregnancy increases the risk of stillbirth.",
author = "K Strandberg-Larsen and M Tinggaard and Andersen, {Anne-Marie Nybo} and J Olsen and M Gr{\o}nbaek",
year = "2008",
doi = "10.1111/j.1471-0528.2008.01867.x",
language = "English",
volume = "115",
pages = "1405--10",
journal = "B J O G",
issn = "1470-0328",
publisher = "Wiley-Blackwell",
number = "11",

}

RIS

TY - JOUR

T1 - Use of nicotine replacement therapy during pregnancy and stillbirth

T2 - a cohort study

AU - Strandberg-Larsen, K

AU - Tinggaard, M

AU - Andersen, Anne-Marie Nybo

AU - Olsen, J

AU - Grønbaek, M

PY - 2008

Y1 - 2008

N2 - OBJECTIVE: The objective of this study was to examine whether the use of nicotine replacement therapy (NRT) during pregnancy increases the risk of stillbirth. DESIGN: Cohort study with prospective data. SETTING: Denmark 1996-2002. POPULATION: A total of 87,032 singleton pregnancies enrolled in the Danish National Birth Cohort for which information on NRT use as well as smoking was available. METHODS: Outcome of pregnancy was identified by register linkage, with <1% loss to follow up. We conducted Cox regression analyses to estimate the hazard ratio (HR) and 95% CI of stillbirth according to the use of NRT, type of NRT use and a combination of NRT use and smoking. MAIN OUTCOME MEASURES: Stillbirth, defined as delivery of a dead fetus after 20 completed weeks of gestation. RESULTS: A total of 495 pregnancies (5.7 in 1000 births) ended in stillbirth, 8 of which were among NRT users (4.2 in 1000 births). After adjustment for confounders, women who used NRT during pregnancy had a HR of 0.57 (95% CI 0.28-1.16) for stillbirth compared with those who did not use NRT. Smoking during pregnancy was associated with an increased risk of stillbirth (HR 1.46, 95% CI 1.17-1.82), while women who both smoked and used NRT had a HR of 0.83 (95% CI 0.34-2.00) compared with nonsmoking women who did not use NRT. CONCLUSION: Our study does not indicate that use of NRT during pregnancy increases the risk of stillbirth.

AB - OBJECTIVE: The objective of this study was to examine whether the use of nicotine replacement therapy (NRT) during pregnancy increases the risk of stillbirth. DESIGN: Cohort study with prospective data. SETTING: Denmark 1996-2002. POPULATION: A total of 87,032 singleton pregnancies enrolled in the Danish National Birth Cohort for which information on NRT use as well as smoking was available. METHODS: Outcome of pregnancy was identified by register linkage, with <1% loss to follow up. We conducted Cox regression analyses to estimate the hazard ratio (HR) and 95% CI of stillbirth according to the use of NRT, type of NRT use and a combination of NRT use and smoking. MAIN OUTCOME MEASURES: Stillbirth, defined as delivery of a dead fetus after 20 completed weeks of gestation. RESULTS: A total of 495 pregnancies (5.7 in 1000 births) ended in stillbirth, 8 of which were among NRT users (4.2 in 1000 births). After adjustment for confounders, women who used NRT during pregnancy had a HR of 0.57 (95% CI 0.28-1.16) for stillbirth compared with those who did not use NRT. Smoking during pregnancy was associated with an increased risk of stillbirth (HR 1.46, 95% CI 1.17-1.82), while women who both smoked and used NRT had a HR of 0.83 (95% CI 0.34-2.00) compared with nonsmoking women who did not use NRT. CONCLUSION: Our study does not indicate that use of NRT during pregnancy increases the risk of stillbirth.

U2 - 10.1111/j.1471-0528.2008.01867.x

DO - 10.1111/j.1471-0528.2008.01867.x

M3 - Journal article

C2 - 18717669

VL - 115

SP - 1405

EP - 1410

JO - B J O G

JF - B J O G

SN - 1470-0328

IS - 11

ER -

ID: 21161635