Estimated exposure to perfluoroalkyl substances during infancy and serum-adipokine concentrations in later childhood
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Estimated exposure to perfluoroalkyl substances during infancy and serum-adipokine concentrations in later childhood. / Grandjean, Philippe; Shih, Yu Hsuan; Jørgensen, Louise Helskov; Nielsen, Flemming; Weihe, Pál; Budtz-Jørgensen, Esben.
In: Pediatric Research, Vol. 94, 2023, p. 1832–1837 .Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - Estimated exposure to perfluoroalkyl substances during infancy and serum-adipokine concentrations in later childhood
AU - Grandjean, Philippe
AU - Shih, Yu Hsuan
AU - Jørgensen, Louise Helskov
AU - Nielsen, Flemming
AU - Weihe, Pál
AU - Budtz-Jørgensen, Esben
N1 - Publisher Copyright: © 2023, The Author(s).
PY - 2023
Y1 - 2023
N2 - Background: Perfluoroalkyl substances (PFASs) are transferred through human milk and may cause elevated exposure during infancy. Given the lack of early postnatal blood samples, PFAS concentrations can be estimated to serve as predictors of subsequent metabolic toxicity. Methods: A total of 298 children from a prospective birth cohort were followed up through to age 9 years. Serum-PFAS was measured at birth and 18 months of age, while exposures during infancy were estimated by structural equations. Adiponectin, resistin, leptin, and the leptin receptor were measured in serum at age 9. Adjusted regression coefficients for estimated serum-PFAS concentrations were calculated, with additional consideration of the duration of breastfeeding and potential effect modification by sex. Results: A doubling in estimated serum-PFAS concentrations, particularly at ages 6 and 12 months, was associated with a loss of about 10–15% in age 9 resistin concentrations, while other associations were much weaker. Sex dependence of the associations was not observed, and neither did the duration of breastfeeding affect outcomes at age 9. Conclusion: Lowered serum-resistin concentrations at age 9 years were most strongly associated with early postnatal PFAS exposures. These findings suggest that infancy may represent a vulnerable time window for some aspects of metabolic programming that may be affected by PFAS exposure. Impact: Serum-PFAS concentrations during infancy can be estimated in the absence of blood samples.Adipokine concentrations were measured at age 9 years as metabolic biomarkers.Resistin was significantly lower in children with elevated PFAS exposures in infancy.The findings suggest that early postnatal PFAS exposures may affect subsequent metabolic health.Assessment of infancy vulnerability to PFAS can be explored using estimated serum-PFAS concentrations.
AB - Background: Perfluoroalkyl substances (PFASs) are transferred through human milk and may cause elevated exposure during infancy. Given the lack of early postnatal blood samples, PFAS concentrations can be estimated to serve as predictors of subsequent metabolic toxicity. Methods: A total of 298 children from a prospective birth cohort were followed up through to age 9 years. Serum-PFAS was measured at birth and 18 months of age, while exposures during infancy were estimated by structural equations. Adiponectin, resistin, leptin, and the leptin receptor were measured in serum at age 9. Adjusted regression coefficients for estimated serum-PFAS concentrations were calculated, with additional consideration of the duration of breastfeeding and potential effect modification by sex. Results: A doubling in estimated serum-PFAS concentrations, particularly at ages 6 and 12 months, was associated with a loss of about 10–15% in age 9 resistin concentrations, while other associations were much weaker. Sex dependence of the associations was not observed, and neither did the duration of breastfeeding affect outcomes at age 9. Conclusion: Lowered serum-resistin concentrations at age 9 years were most strongly associated with early postnatal PFAS exposures. These findings suggest that infancy may represent a vulnerable time window for some aspects of metabolic programming that may be affected by PFAS exposure. Impact: Serum-PFAS concentrations during infancy can be estimated in the absence of blood samples.Adipokine concentrations were measured at age 9 years as metabolic biomarkers.Resistin was significantly lower in children with elevated PFAS exposures in infancy.The findings suggest that early postnatal PFAS exposures may affect subsequent metabolic health.Assessment of infancy vulnerability to PFAS can be explored using estimated serum-PFAS concentrations.
U2 - 10.1038/s41390-023-02665-4
DO - 10.1038/s41390-023-02665-4
M3 - Journal article
C2 - 37316707
AN - SCOPUS:85161933450
VL - 94
SP - 1832
EP - 1837
JO - Pediatric Research
JF - Pediatric Research
SN - 0031-3998
ER -
ID: 358567245