Higher risk of cerebral palsy, seizures/epilepsy, visual- and hearing impairments, cancer, injury and child abuse in children with congenital anomalies: Data from the EUROlinkCAT study
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Higher risk of cerebral palsy, seizures/epilepsy, visual- and hearing impairments, cancer, injury and child abuse in children with congenital anomalies : Data from the EUROlinkCAT study. / Urhoj, Stine Kjaer; Morris, Joan; Loane, Maria; Ballardini, Elisa; Barrachina-Bonet, Laia; Cavero-Carbonell, Clara; Coi, Alessio; Gissler, Mika; Given, Joanne; Heino, Anna; Jordan, Sue; Neville, Amanda; Santoro, Michele; Tan, Joachim; Tucker, David; Wellesley, Diana; Garne, Ester; Damkjaer, Mads.
In: Acta paediatrica (Oslo, Norway : 1992), Vol. 113, No. 5, 2024, p. 1024-1031.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Higher risk of cerebral palsy, seizures/epilepsy, visual- and hearing impairments, cancer, injury and child abuse in children with congenital anomalies
T2 - Data from the EUROlinkCAT study
AU - Urhoj, Stine Kjaer
AU - Morris, Joan
AU - Loane, Maria
AU - Ballardini, Elisa
AU - Barrachina-Bonet, Laia
AU - Cavero-Carbonell, Clara
AU - Coi, Alessio
AU - Gissler, Mika
AU - Given, Joanne
AU - Heino, Anna
AU - Jordan, Sue
AU - Neville, Amanda
AU - Santoro, Michele
AU - Tan, Joachim
AU - Tucker, David
AU - Wellesley, Diana
AU - Garne, Ester
AU - Damkjaer, Mads
N1 - © 2024 The Authors. Acta Paediatrica published by John Wiley & Sons Ltd on behalf of Foundation Acta Paediatrica.
PY - 2024
Y1 - 2024
N2 - AIM: The aim is to examine the risk of cerebral palsy, seizures/epilepsy, visual- and hearing impairments, cancer, injury/poisoning and child abuse in children with and without a congenital anomaly up to age 5 and 10 years.METHODS: This is a population-based data linkage cohort study linking information from the European Surveillance of Congenital Anomalies network (EUROCAT) and birth registries to hospital discharge databases. We included 91 504 live born children with major congenital anomalies born from 1995 to 2014 from nine EUROCAT registries in five countries and 1 960 727 live born children without congenital anomalies (reference children). Prevalence and relative risk (RR) were estimated for each of the co-morbidities using Kaplan-Meier survival estimates.RESULTS: Children with congenital anomalies had higher risks of the co-morbidities than reference children. The prevalences in the reference children were generally very low. The RR was 13.8 (95% CI 12.5-15.1) for cerebral palsy, 2.5 (95% CI 2.4-2.6) for seizures/epilepsy, 40.8 (95% CI 33.2-50.2) for visual impairments, 10.0 (95% CI 9.2-10.9) for hearing loss, 3.6 (95% CI 3.2-4.2) for cancer, 1.5 (95% CI 1.4-1.5) for injuries/poisoning and 2.4 (95% CI 1.7-3.4) for child abuse.CONCLUSION: Children with congenital anomalies were more likely to be diagnosed with the specified co-morbidities compared to reference children.
AB - AIM: The aim is to examine the risk of cerebral palsy, seizures/epilepsy, visual- and hearing impairments, cancer, injury/poisoning and child abuse in children with and without a congenital anomaly up to age 5 and 10 years.METHODS: This is a population-based data linkage cohort study linking information from the European Surveillance of Congenital Anomalies network (EUROCAT) and birth registries to hospital discharge databases. We included 91 504 live born children with major congenital anomalies born from 1995 to 2014 from nine EUROCAT registries in five countries and 1 960 727 live born children without congenital anomalies (reference children). Prevalence and relative risk (RR) were estimated for each of the co-morbidities using Kaplan-Meier survival estimates.RESULTS: Children with congenital anomalies had higher risks of the co-morbidities than reference children. The prevalences in the reference children were generally very low. The RR was 13.8 (95% CI 12.5-15.1) for cerebral palsy, 2.5 (95% CI 2.4-2.6) for seizures/epilepsy, 40.8 (95% CI 33.2-50.2) for visual impairments, 10.0 (95% CI 9.2-10.9) for hearing loss, 3.6 (95% CI 3.2-4.2) for cancer, 1.5 (95% CI 1.4-1.5) for injuries/poisoning and 2.4 (95% CI 1.7-3.4) for child abuse.CONCLUSION: Children with congenital anomalies were more likely to be diagnosed with the specified co-morbidities compared to reference children.
U2 - 10.1111/apa.17136
DO - 10.1111/apa.17136
M3 - Journal article
C2 - 38324400
VL - 113
SP - 1024
EP - 1031
JO - Acta Paediatrica
JF - Acta Paediatrica
SN - 0803-5253
IS - 5
ER -
ID: 382094053