Harrie C.M. Boonen
External examinor
Education & Student Services
Jagtvej 160, 2100 København Ø, Bygning 21, Building: 105
Primary fields of research
My primary field of research has, since 1987, been vascular pharmacology and physiology. Initially (Maastricht University) focussing on changes in vascular function and structure in animal models of hypertension but changing towards vascular pathophysiology of diabetes and obesity during my 15 years in the pharmaceutical industry (Novo Nordisk).
Basic in vivo and in vitro vascular research at Maastricht University was supplemented with applied vascular research during the period in the pharmaceutical industry (Novo Nordisk) were the emphasis was on discovery and development of novel oral anti-diabetic treatments, and the first generation of modern insulins. Drug development led my interest into exploratory safety and safety assessment of new drugs and the translational aspects of this process.
Systems Pharmacology
Current research is aimed at finding and utilising novel computational methods enabling multi-level integrative simulations of biological systems and the changes herein as a result of disease or treatment. Adaptation of vascular function in health and disease is the framework that will be used to achieve this goal.
Fields of interest
Cardiovascular Pharmacology and Physiology,
Complex adaptive systems (CAS),
Drug development and safety assessment
Diabetes, Metabolism, Hypertension
ID: 12697485
Most downloads
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1909
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Genetic fuzzy system modeling and simulation of vascular behaviour
Research output: Contribution to conference › Poster › Research › peer-review
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1756
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Functional network analysis of obese and lean Göttingen minipigs elucidates changes in oxidative and inflammatory networks in obese pigs
Research output: Contribution to journal › Journal article › Research › peer-review
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1589
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Pattern-oriented Agent-based Monte Carlo simulation of Cellular Redox Environment
Research output: Contribution to conference › Poster › Research
Published