Associations between birth size and later height from infancy through adulthood: An individual based pooled analysis of 28 twin cohorts participating in the CODATwins project
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Associations between birth size and later height from infancy through adulthood : An individual based pooled analysis of 28 twin cohorts participating in the CODATwins project. / Jelenkovic, Aline; Yokoyama, Yoshie; Sund, Reijo; Hur, Yoon-Mi; Harris, Jennifer R; Brandt, Ingunn; Nilsen, Thomas Sevenius; Ooki, Syuichi; Ullemar, Vilhelmina; Almqvist, Catarina; Magnusson, Patrik K E; Saudino, Kimberly J; Stazi, Maria A; Fagnani, Corrado; Brescianini, Sonia; Nelson, Tracy L; Whitfield, Keith E; Knafo-Noam, Ariel; Mankuta, David; Abramson, Lior; Cutler, Tessa L; Hopper, John L; Llewellyn, Clare H; Fisher, Abigail; Corley, Robin P; Huibregtse, Brooke M; Derom, Catherine A; Vlietinck, Robert F; Bjerregaard-Andersen, Morten; Beck-Nielsen, Henning; Sodemann, Morten; Krueger, Robert F; McGue, Matt; Pahlen, Shandell; Alexandra Burt, S; Klump, Kelly L; Dubois, Lise; Boivin, Michel; Brendgen, Mara; Dionne, Ginette; Vitaro, Frank; Willemsen, Gonneke; Bartels, Meike; van Beijsterveld, Catharina E M; Craig, Jeffrey M; Saffery, Richard; Rasmussen, Finn; Tynelius, Per; Heikkilä, Kauko; Sørensen, Thorkild I. A.; et al.
In: Early Human Development, Vol. 120, 2018, p. 53-60.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Associations between birth size and later height from infancy through adulthood
T2 - An individual based pooled analysis of 28 twin cohorts participating in the CODATwins project
AU - Jelenkovic, Aline
AU - Yokoyama, Yoshie
AU - Sund, Reijo
AU - Hur, Yoon-Mi
AU - Harris, Jennifer R
AU - Brandt, Ingunn
AU - Nilsen, Thomas Sevenius
AU - Ooki, Syuichi
AU - Ullemar, Vilhelmina
AU - Almqvist, Catarina
AU - Magnusson, Patrik K E
AU - Saudino, Kimberly J
AU - Stazi, Maria A
AU - Fagnani, Corrado
AU - Brescianini, Sonia
AU - Nelson, Tracy L
AU - Whitfield, Keith E
AU - Knafo-Noam, Ariel
AU - Mankuta, David
AU - Abramson, Lior
AU - Cutler, Tessa L
AU - Hopper, John L
AU - Llewellyn, Clare H
AU - Fisher, Abigail
AU - Corley, Robin P
AU - Huibregtse, Brooke M
AU - Derom, Catherine A
AU - Vlietinck, Robert F
AU - Bjerregaard-Andersen, Morten
AU - Beck-Nielsen, Henning
AU - Sodemann, Morten
AU - Krueger, Robert F
AU - McGue, Matt
AU - Pahlen, Shandell
AU - Alexandra Burt, S
AU - Klump, Kelly L
AU - Dubois, Lise
AU - Boivin, Michel
AU - Brendgen, Mara
AU - Dionne, Ginette
AU - Vitaro, Frank
AU - Willemsen, Gonneke
AU - Bartels, Meike
AU - van Beijsterveld, Catharina E M
AU - Craig, Jeffrey M
AU - Saffery, Richard
AU - Rasmussen, Finn
AU - Tynelius, Per
AU - Heikkilä, Kauko
AU - Sørensen, Thorkild I. A.
AU - et al.
N1 - Copyright © 2018 The Authors. Published by Elsevier B.V. All rights reserved.
PY - 2018
Y1 - 2018
N2 - BACKGROUND: There is evidence that birth size is positively associated with height in later life, but it remains unclear whether this is explained by genetic factors or the intrauterine environment.AIM: To analyze the associations of birth weight, length and ponderal index with height from infancy through adulthood within mono- and dizygotic twin pairs, which provides insights into the role of genetic and environmental individual-specific factors.METHODS: This study is based on the data from 28 twin cohorts in 17 countries. The pooled data included 41,852 complete twin pairs (55% monozygotic and 45% same-sex dizygotic) with information on birth weight and a total of 112,409 paired height measurements at ages ranging from 1 to 69 years. Birth length was available for 19,881 complete twin pairs, with a total of 72,692 paired height measurements. The association between birth size and later height was analyzed at both the individual and within-pair level by linear regression analyses.RESULTS: Within twin pairs, regression coefficients showed that a 1-kg increase in birth weight and a 1-cm increase in birth length were associated with 1.14-4.25 cm and 0.18-0.90 cm taller height, respectively. The magnitude of the associations was generally greater within dizygotic than within monozygotic twin pairs, and this difference between zygosities was more pronounced for birth length.CONCLUSION: Both genetic and individual-specific environmental factors play a role in the association between birth size and later height from infancy to adulthood, with a larger role for genetics in the association with birth length than with birth weight.
AB - BACKGROUND: There is evidence that birth size is positively associated with height in later life, but it remains unclear whether this is explained by genetic factors or the intrauterine environment.AIM: To analyze the associations of birth weight, length and ponderal index with height from infancy through adulthood within mono- and dizygotic twin pairs, which provides insights into the role of genetic and environmental individual-specific factors.METHODS: This study is based on the data from 28 twin cohorts in 17 countries. The pooled data included 41,852 complete twin pairs (55% monozygotic and 45% same-sex dizygotic) with information on birth weight and a total of 112,409 paired height measurements at ages ranging from 1 to 69 years. Birth length was available for 19,881 complete twin pairs, with a total of 72,692 paired height measurements. The association between birth size and later height was analyzed at both the individual and within-pair level by linear regression analyses.RESULTS: Within twin pairs, regression coefficients showed that a 1-kg increase in birth weight and a 1-cm increase in birth length were associated with 1.14-4.25 cm and 0.18-0.90 cm taller height, respectively. The magnitude of the associations was generally greater within dizygotic than within monozygotic twin pairs, and this difference between zygosities was more pronounced for birth length.CONCLUSION: Both genetic and individual-specific environmental factors play a role in the association between birth size and later height from infancy to adulthood, with a larger role for genetics in the association with birth length than with birth weight.
U2 - 10.1016/j.earlhumdev.2018.04.004
DO - 10.1016/j.earlhumdev.2018.04.004
M3 - Journal article
C2 - 29656171
VL - 120
SP - 53
EP - 60
JO - Early Human Development
JF - Early Human Development
SN - 0378-3782
ER -
ID: 202026049