Associations between placental DNA methylation and emotional and behavioral outcomes in preschoolers: insights from the EDEN Mother-Child Cohort study
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Associations between placental DNA methylation and emotional and behavioral outcomes in preschoolers : insights from the EDEN Mother-Child Cohort study. / Nakamura, A.; Broseus, L.; Tost, J.; Vaiman, D.; Martins, S.; Keyes, K.; Bonello, K.; Fekom, M.; Strandberg-larsen, K.; Sutter-dallay, A.-l.; Melchior, M.; Heude, B.; Lepeule, J.
In: European Psychiatry, Vol. 66, No. S1, 2023, p. S532-S533.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Associations between placental DNA methylation and emotional and behavioral outcomes in preschoolers
T2 - insights from the EDEN Mother-Child Cohort study
AU - Nakamura, A.
AU - Broseus, L.
AU - Tost, J.
AU - Vaiman, D.
AU - Martins, S.
AU - Keyes, K.
AU - Bonello, K.
AU - Fekom, M.
AU - Strandberg-larsen, K.
AU - Sutter-dallay, A.-l.
AU - Melchior, M.
AU - Heude, B.
AU - Lepeule, J.
PY - 2023
Y1 - 2023
N2 - IntroductionBehavioral (externalizing) and emotional (internalizing) problems were showed to be associated with the prenatal environment. Changes in placental DNA methylation was identified as a relevant potential mechanism of such association.ObjectivesWe aimed to explore the associations between placental DNA methylation and child behavior in order to explore pathways that could link prenatal exposures to child behavior.MethodsData including 441 children of 3 years of age from the EDEN mother-child cohort. Child behavior assessed using the Strengths and Difficulties Questionnaire (SDQ). Both hypotheses-driven and exploratory analyses (including epigenome-wide association studies (EWAS) and differentially methylated regions (DMR) analyses) were conducted. The analyses were adjusted for confounding and technical factors and estimated placental cell composition. All the p-values were corrected using a false discovery rate (FDR) procedure for multiple tests.ResultsIn the hypothesis-driven analysis, cg26703534 (AHRR), was significantly associated with emotional problems (pFDR = 0.03). In the exploratory analyses, cg09126090 (pFDR = 0.04) and cg10305789 (PPP1R16B; pFDR < 0.01) were significantly associated with peer-relationship problems and 33 DMRs were significantly associated with at least one of the SDQ subscales. Placental DNA methylation showed more associations with internalizing than externalizing symptoms, especially among girls. DMRs tented to include highly methylated CpGs.ConclusionsThis study investigated for the first time the associations between placental DNA methylation and internalizing and externalizing symptoms in preschoolers. Further analyses, such as consortium meta-analyses would be necessary to confirm and extend our results.
AB - IntroductionBehavioral (externalizing) and emotional (internalizing) problems were showed to be associated with the prenatal environment. Changes in placental DNA methylation was identified as a relevant potential mechanism of such association.ObjectivesWe aimed to explore the associations between placental DNA methylation and child behavior in order to explore pathways that could link prenatal exposures to child behavior.MethodsData including 441 children of 3 years of age from the EDEN mother-child cohort. Child behavior assessed using the Strengths and Difficulties Questionnaire (SDQ). Both hypotheses-driven and exploratory analyses (including epigenome-wide association studies (EWAS) and differentially methylated regions (DMR) analyses) were conducted. The analyses were adjusted for confounding and technical factors and estimated placental cell composition. All the p-values were corrected using a false discovery rate (FDR) procedure for multiple tests.ResultsIn the hypothesis-driven analysis, cg26703534 (AHRR), was significantly associated with emotional problems (pFDR = 0.03). In the exploratory analyses, cg09126090 (pFDR = 0.04) and cg10305789 (PPP1R16B; pFDR < 0.01) were significantly associated with peer-relationship problems and 33 DMRs were significantly associated with at least one of the SDQ subscales. Placental DNA methylation showed more associations with internalizing than externalizing symptoms, especially among girls. DMRs tented to include highly methylated CpGs.ConclusionsThis study investigated for the first time the associations between placental DNA methylation and internalizing and externalizing symptoms in preschoolers. Further analyses, such as consortium meta-analyses would be necessary to confirm and extend our results.
U2 - 10.1192/j.eurpsy.2023.1127
DO - 10.1192/j.eurpsy.2023.1127
M3 - Journal article
VL - 66
SP - S532-S533
JO - European Psychiatry
JF - European Psychiatry
SN - 0924-9338
IS - S1
ER -
ID: 370662048