Research areas

  1. Published

    Phorbol Rearrangements

    Zimmermann, T., Franzyk, Henrik & Christensen, Søren Brøgger, 15 Sep 2018, In : Journal of Natural Products. 81, 9, p. 2134-2137 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    Preparation of Enzyme-Activated Thapsigargin Prodrugs by Solid-Phase Synthesis

    Zimmermann, T., Christensen, Søren Brøgger & Franzyk, Henrik, 15 Jun 2018, In : Molecules. 23, 6, 13 p., 1463.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Urban Displacement and Resettlement in Zimbabwe: The Paradoxes of Propertied Citizenship

    Hammar, Amanda, Dec 2017, In : African Studies Review.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Lithostratigraphy, geology and geochemisttry of the volcanic rocks of the Vaigat Formation on Disko and Nuussuaq, Paleocene of West Greenland

    Pedersen, Asger Ken, Larsen, L. M. & Pedersen, G. K., 2017, Copenhagen: The Geological Survey of Denmark and Greenland. 244 p. (Geological Survey of Denmark and Greenland (GEUS) Bulletin, Vol. 39).

    Research output: Book/ReportBookResearchpeer-review

  5. Published

    Molecular Hybridization of Potent and Selective γ-Hydroxybutyric Acid (GHB) Ligands: Design, Synthesis, Binding Studies, and Molecular Modeling of Novel 3-Hydroxycyclopent-1-enecarboxylic Acid (HOCPCA) and trans-γ-Hydroxycrotonic Acid (T-HCA) Analogs

    Krall, J., Jensen, C. H., Bavo, F., Falk-Petersen, Christina Birkedahl, Haugaard, A. S., Vogensen, S. B., Tian, Y., Nittegaard-Nielsen, M., Sigurdardóttir, S. B., Kehler, J., Kongstad, Kenneth Thermann, Gloriam, David E., Clausen, Rasmus Prætorius, Harpsøe, Kasper, Wellendorph, Petrine & Frølund, Bente, 2017, In : Journal of Medicinal Chemistry. 60, 21, p. 9022-9039 18 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Structure/activity Relationship of Thapsigargin Inhibition on the Purified Golgi/secretory Pathway Ca2+/Mn2+-Transport ATPase (SPCA1a)

    Jialin, C., de Raeymaecker, J., Hovgaard, J. B., Smaardijk, S., Vandecaetsbeek, I., Wuytack, F., Møller, J. V., Eggermont, J., de Meyer, M., Christensen, Søren Brøgger & Vangheluwe, P., 2017, In : Journal of Biological Chemistry. 292, 17, p. 6938-6951 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Basic characteristics and kinetics of degradation in aqueous buffer of selected diclofenac prodrugs intended for joint injection

    Mertz, Nina, Larsen, Susan Weng & Larsen, C. S., 6 Apr 2016. 1 p.

    Research output: Contribution to conferencePosterResearchpeer-review

  8. Published

    The potential of protein-nanomaterial interaction for advanced drug delivery

    Peng, Q. & Mu, Huiling, 23 Jan 2016, In : Journal of Controlled Release. 225, p. 121-132 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Cytochrome P450 Mediated Drug Metabolism

    Olsen, L., Jørgensen, Flemming Steen & Oostenbrink, C., 2016, New Horizons in Predictive Drug Metabolism and Pharmacokinetics. Wilson, A. G. E. (ed.). Cambridge: Royal Society of Chemistry, p. 66-78 13 p. (RSC Drug Discovery, Vol. 49).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  10. Published

    Iminolactones as Tools for Inversion of the Absolute Configuration of alpha-Amino Acids and as Inhibitors of Cancer Cell Proliferation

    Jensen, C. M., Chow, H., Chen, M., Zhai, L., Frydenvang, Karla Andrea, Liu, H., Franzyk, Henrik & Christensen, Søren Brøgger, 2016, In : European Journal of Medicinal Chemistry. 114, p. 118-133 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Thapsigargin, origin, chemistry, structure-activity relationships and prodrug development.

    Doan, T. Q. N. & Christensen, Søren Brøgger, Oct 2015, In : Current Pharmaceutical Design. 21, 38, p. 5505-5517 13 p.

    Research output: Contribution to journalReviewResearchpeer-review

  12. Published

    Selecting key toxins for focused development of elapid snake antivenoms and inhibitors guided by a Toxicity Score

    Laustsen, A. H. & Lohse, Brian, 15 Sep 2015, In : Toxicon. 104, p. 43-45 3 p.

    Research output: Contribution to journalLetterResearchpeer-review

  13. Published

    Kolliphor surfactants affect solubilization and bioavailability of fenofibrate. Studies of in vitro digestion and absorption in rats.

    Berthelsen, Ragna, Holm, R., Jacobsen, Jette, Kristensen, J., Abrahamsson, B. & Mullertz, Anette , 6 Apr 2015, In : Molecular Pharmaceutics. 12, 4, p. 1062-1071 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Noter til Organisk Kemi for Biovidenskab: Organisk og bioorganisk kemi 2015

    Nielsen, John, 9 Feb 2015, 25 p.

    Research output: Other contributionEducation

  15. Published

    Investigations and design of pyridine-2-carboxylic acid thiazol-2-ylamide analogs as methionine aminopeptidase inhibitors using 3D-QSAR and molecular docking

    Hauser, Alexander Sebastian, 1 Aug 2014, In : Medicinal Chemistry Research. 23, 8, p. 3861 3875 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    The PPARalpha agonist, fenofibrate decreases levels of anorectic N-acylethanolamines in the small intestine of mice

    Diep, T. A., Golbas, G. & Hansen, Harald S., 28 Jun 2014. 1 p.

    Research output: Contribution to conferenceConference abstract for conferenceResearch

  17. Published

    Organ culture of C57BL/6 mouse arteries with LPS as an in vitro model of vascular inflammation

    Outzen, E. M., Mehryar, R., Boonen, Harrie C.M., Nielsen, A. S. & Sheykhzade, Majid, 28 Aug 2013. 1 p.

    Research output: Contribution to conferencePosterResearch

  18. Published

    Pattern-oriented Agent-based Monte Carlo simulation of Cellular Redox Environment

    Tang, J., Holcombe, M. & Boonen, Harrie C.M., 28 Aug 2013. 1 p.

    Research output: Contribution to conferencePosterResearch

  19. Published

    Prolonged naproxen joint residence time after intra-articular injection of lipophilic solutions comprising a naproxen glycolamide ester prodrug in the rat

    Thing, M., Lu, Y., Agårdh, L., Larsen, C. S., Østergaard, Jesper, He, W., Wu, W., Larsen, F. & Larsen, Susan Weng, 15 Jul 2013, In : International Journal of Pharmaceutics. 451, 1-2, p. 34-40 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Liposomal temocene (m-THPPo) photodynamic treatment induces cell death by mitochondria-independent apoptosis

    Soriano, J., Garcia-Diaz, M., Mora, M., Sagristá, M. L., Nonell, S., Villanueva, A., Stockert, J. C. & Cañete, M., 28 May 2013, In : BBA General Subjects. 1830, 10, p. 4611-4620 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Development and validation of an SPE methodology combined with LC-MS/MS for the determination of four ionophores in aqueous environmental matrices

    Bak, S. A., Hansen, M., Krogh, K. A., Brandt, A., Halling-Sørensen, B. & Björklund, E., 25 Feb 2013, In : International Journal of Environmental Analytical Chemistry. 93, 14, p. 1500-1512

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Altered anziety/depression-like behaviours in mice deficient in tetrahydrobiopterin

    Nasser, A., Birk Møller, L. & Andreasen T., Jesper, 13 Jan 2013.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  23. Exploring the solid-form landscape of pharmaceutical hydrates: transformation pathways of the sodium naproxen anhydrate-hydrate system

    Raijada, D. K., Bond, A., Larsen, F. H., Cornett, C., Qu, H. & Rantanen, J., Jan 2013, In : Pharmaceutical Research. 30, 1, p. 280-289 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Exploring the solid-form landscape of pharmaceutical hydrates: transformation pathways of the sodium naproxen anhydrate-hydrate system

    Raijada, D. K., Bond, A., Larsen, F. H., Cornett, Claus, Qu, H. & Rantanen, Jukka, 2013, In : Pharmaceutical Research. 30, 1, p. 280-289 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Lactate dehydrogenase assay for assessment of polycation cytotoxicity

    Parhamifar, L., Andersen, H. & Moghimi, S. M., 2013, Nanotechnology for Nucleic Acid Delivery. Vol. 948. p. 13-22 10 p. (Methods in Molecular Biology).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

  26. Published

    Pollution Pathways of Pharmaceutical Residues in the Aquatic Environment on the Island of Mallorca, Spain

    Rodríguez-Navas, C., Björklund, E., Bak, S. A., Hansen, M., Krogh, K. A., Maya, F., Forteza, R. & Cerdà, V., 2013, In : Archives of Environmental Contamination and Toxicology. 61, 1, p. 56-66

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Strategic funding priorities in the pharmaceutical sciences allied to Quality by Design (QbD) and Process Analytical Technology (PAT)

    Aksu, B., De Beer, T., Folestad, S., Ketolainen, J., Lindén, H., Lopes, J. A., de Matas, M., Oostra, W., Rantanen, Jukka & Weimer, M., 29 Sep 2012, In : European Journal of Pharmaceutical Sciences. 47, 2, p. 402-405 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Quality assessment of Tulbaghia rhizomes

    Jäger, A. & Stafford, G. I., Sep 2012, In : South African Journal of Botany. 82, p. 92-98 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Solvent-mediated amorphous-to-crystalline transformation of nitrendipine in amorphous particle suspensions containing polymers

    Xia, D., Wu, J., Cui, F., Qu, H., Rades, Thomas, Rantanen, Jukka & Yang, Mingshi, 15 Aug 2012, In : European Journal of Pharmaceutical Sciences. 46, 5, p. 446-454 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Genetic fuzzy system modeling and simulation of vascular behaviour

    Tang, J. & Boonen, Harrie C.M., 13 Jun 2012. 1 p.

    Research output: Contribution to conferencePosterResearchpeer-review

  31. Published

    Studies of H3K4me3 demethylation by KDM5B/Jarid1B/PLU1 reveals strong substrate recognition in vitro and identifies 2,4-pyridine-dicarboxylic acid as an in vitro and in cell inhibitor

    Kristensen, L. H., Nielsen, A. L., Helgstrand, C., Lees, M., Cloos, Paul, Kastrup, Jette Sandholm Jensen, Helin, Kristian, Olsen, L. & Gajhede, Michael, Jun 2012, In : F E B S Journal. 279, 11, p. 1905-1914

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Chemical composition of the essential oil from Microlicia graveolens growing wild in Minas Gerais

    Toudahl, A. B., Filho, S. A. V., Souza, G. H. B., Morais, L. D., dos Santos, O. D. H. & Jäger, A., May 2012, In : Revista Brasileira de Farmacognosia. 22, 3, p. 680-681

    Research output: Contribution to journalLetterResearchpeer-review

  33. Published

    Comment on "Binding free energies of inhibitors to iron porphyrin complex as a model for cytochrome P450"

    Rydberg, P., Apr 2012, In : Biopolymers. 97, 4, p. 250-251

    Research output: Contribution to journalComment/debateResearchpeer-review

  34. Published

    Concise synthesis of new bridged-nicotine analogues

    Crestey, F., Hooyberghs, G. & Kristensen, Jesper Langgaard, 4 Feb 2012, In : Tetrahedron. 68, 5, p. 1417-1421

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Intersubunit bridge formation governs agonist efficacy at nicotinic acetylcholine alpha4beta2 receptors: Unique role of halogen bonding revealed

    Rohde, L. A. H., Ahring, P. K., Jensen, M. L., Nielsen, E. Ø., Peters, D., Helgstrand, C., Krintel, C., Harpsøe, Kasper, Gajhede, Michael, Kastrup, Jette Sandholm Jensen & Balle, T., 3 Feb 2012, In : The Journal of Biological Chemistry. 287, 6, p. 4248-4259

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    3-Alkyl- and 3-amido-isothiazoloquinolin-4-ones as ligands for the benzodiazepine site of GABAA receptors

    Nilsson, J., Nielsen, E. Ø., Liljefors, T., Nielsen, M. P. C. & Sterner, O., Feb 2012, In : Bioorganic Chemistry. 40, p. 125-130

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Biased agonism of the calcium-sensing receptor

    Thomsen, A. R. B., Hvidtfeldt, M. & Bräuner-Osborne, Hans, Feb 2012, In : Cell Calcium. 51, 2, p. 107-116

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Ligand-based site of metabolism prediction for cytochrome P450 2D6

    Rydberg, P. & Olsen, L., 12 Jan 2012, In : A C S Medicinal Chemistry Letters. 3, 1, p. 69-73

    Research output: Contribution to journalLetterResearchpeer-review

  39. Published

    (1S, 3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid (CPP-115), a potent gamma-aminobutyric acid aminotransferase inactivator for the treatment of cocaine addiction

    Pan, Y., Gerasimov, M. R., Kvist, T., Wellendorph, Petrine, Madsen, K. K., Pera, E., Lee, H., Schousboe, Arne, Chebib, M., Bräuner-Osborne, Hans, Craft, C. M., Brodie, J. D., Schiffer, W. K., Dewey, S. L., Miller, S. R. & Silverman, R. B., 1 Jan 2012, In : Journal of Medicinal Chemistry. 55, 1, p. 357-366

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Thermodynamics and structural analysis of positive allosteric modulation of the ionotropic glutamate receptor GluA2

    Krintel, C., Frydenvang, Karla Andrea, Olsen, L., Kristensen, M. T., de Barrios, O., Naur, P., Francotte, P., Pirotte, B., Gajhede, Michael & Kastrup, Jette Sandholm Jensen, 1 Jan 2012, In : Biochemical Journal. 441, 1, p. 173-178

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Evaluation of the antibacterial activity of Chilean plants traditionally used for wound healing therapy against multidrug-resistant Staphylococcus aureus

    Holler, J. G., Søndergaard, K., Slotved, H., Gúzman, A. & Mølgaard, Per, Jan 2012, In : Planta Medica. 78, 2, p. 200-205

    Research output: Contribution to journalLetterResearchpeer-review

  42. Published

    Side-chain interactions form late and cooperatively in the binding reaction between disordered peptides and PDZ domains

    Haq, S. R., Chi, C. N., Bach, Anders, Dogan, J., Engström, Å., Hultqvist, G., Karlsson, O. A., Lundström, P., Montemiglio, L. C., Strømgaard, Kristian, Gianni, S. & Jemth, P., Jan 2012, In : Journal of the American Chemical Society. 134, 1, p. 599-605

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    In vitro efficacy testing of praziquantel, ivermectin, and oxfendazole against Taenia Solium cysts

    Cederberg, S., Sikasunge, C. S., Andersson, Å. & Johansen, Maria Vang, 2012, In : Journal of Parasitology Research. 2012, 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    In vitro release from oil injectabels for intra-articular administration: importance of interfacial area, diffusivity and partitioning

    Thing, M. A., Larsen, C. S., Østergaard, Jesper, Jensen, H. & Larsen, Susan Weng, 2012, In : European Journal of Pharmaceutical Sciences. 45, 3, p. 351-357

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    A 3D-QSAR-driven approach to binding mode and affinity prediction

    Tosco, P. & Balle, T., 2012, In : Journal of Chemical Information and Modeling. 52, 2, p. 302-307

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    A robust force field based method for calculating conformational energies of charged drug-like molecules

    Pøhlsgaard, J., Harpsøe, Kasper, Jørgensen, Flemming Steen & Olsen, L., 2012, In : Journal of Chemical Information and Modeling. 52, 2, p. 409-419

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Absorption difference between diacylglycerol oil and butter blend containing deacylglycerol oil

    Kristensen, J. B., Jørgensen, H. & Mu, Huiling, 2012, In : European Journal of Lipid Science and Technology. 114, 2, p. 146-152

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    An electrochemical approach to protein adsorption at charged interfaces

    Hartvig, R. A., 2012, København: Det Farmaceutiske Fakultet. 127 p.

    Research output: Book/ReportPh.D. thesisResearch

  49. Published

    Assessing element-specific patterns of bioaccumulation across New England lakes

    Ward, D. M., Mayes, B., Stürup, Stefan, Folt, C. L. & Chen, C. Y., 2012, In : Science of the Total Environment. 421-422, 3-4, p. 230-237

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Behaviour of HPMC compacts investigated using UV-imaging

    Pekka Pajander, J., Baldursdottir, S. G., Rantanen, Jukka & Østergaard, Jesper, 2012, In : International Journal of Pharmaceutics. 427, 2, p. 345-353

    Research output: Contribution to journalJournal articleResearchpeer-review

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