Research areas

  1. Published

    Direct on-line monitoring of methylseleninic acid metabolism in hepatocytes using membrane inlet mass spectrometry

    Bak, S. A., Hansen, H. R., Badolo, L. & Lauritsen, F. R., Jul 2011.

    Research output: Contribution to conferencePosterResearch

  2. Published

    Enzyme kinetic studies of histone demethylases KDM4C and KDM6A: Towards understanding selectivity of inhibitors targeting oncogenic histone demethylases

    Kristensen, J. B. L., Nielsen, A. L., Jørgensen, L., Kristensen, L. H., Helgstrand, C., Juknaite, L., Kristensen, Jesper Langgaard, Kastrup, Jette Sandholm Jensen, Clausen, Rasmus Prætorius, Olsen, L. & Gajhede, Michael, 23 Jun 2011, In : F E B S Letters. 585, 12, p. 1951-1956

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Bacterial membrane activity of alpha-peptide/beta-peptoid chimeras: influence of amino acid composition and chain length on the activity against different bacterial strains

    Hein-Kristensen, L., Knapp, K. M., Franzyk, Henrik & Gram, L., 22 Jun 2011, In : B M C Microbiology. 11, 1, p. 144

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Deletion of the betaine-GABA transporter (BGT1; slc6a12) gene does not affect seizure thresholds of adult mice

    Lehre, A. C., Rowley, N. M., Zhou, Y., Holmseth, S., Guo, C., Holen, T., Hua, R., Laake, P., Olofsson, A. M., Poblete-Naredo, I., Rusakov, D. A., Madsen, K. K., Clausen, Rasmus Prætorius, Schousboe, Arne, White, H. S. & Danbolt, N. C., 1 Jun 2011, In : Epilepsy Research. 95, 1-2, p. 70-81

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Mechanism of Ca2+/calmodulin-dependent kinase II regulation of AMPA receptor gating

    Kristensen, Anders Skov, Jenkins, M. A., Banke, T. G., Schousboe, Arne, Makino, Y., Johnson, R. C., Huganir, R. & Traynelis, S. F., 1 Jun 2011, In : Nature Neuroscience. 14, 6, p. 727-735

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Synthesis of neurotransmitter GABA via the neuronal tricarboxylic acid cycle is elevated in rats with liver cirrhosis consistent with a high GABAergic tone in chronic hepatic encephalopathy

    Leke, R., Bak, Lasse Kristoffer, Iversen, P., Sørensen, M., Keiding, S., Vilstrup, H., Ott, P., Portela, L. V., Schousboe, Arne & Waagepetersen, Helle S., 1 Jun 2011, In : Journal of Neurochemistry. 117, 5, p. 824-32 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    In silico predictions of hERG channel blockers in drug discovery: from ligand-based and target-based approaches to systems chemical biology

    Taboureau, O. & Jørgensen, Flemming Steen, Jun 2011, In : Combinatorial Chemistry & High Throughput Screening. 14, 5, p. 375-387

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Epitope grafting, re-creating a conformational Bet v 1 antibody epitope on the surface of the homologous apple allergen Mal d 1

    Holm, J., Ferreras, M., Ipsen, H., Würtzen, P. A., Gajhede, Michael, Larsen, J. N., Lund, K. & Spangfort, M. D., 20 May 2011, In : Journal of Biological Chemistry. 286, 20, p. 17569-17578

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Expression and beta-glucan binding properties of Scots pine (Pinus sylvestris L.) antimicrobial protein (Sp-AMP)

    Sooriyaarachchi, S., Jaber, E., Covarrubias, A. S., Ubhayasekera, W., Asiegbu, F. O. & Mowbray, S. L., 17 May 2011, In : Plant Molecular Biology. 77, 1-2, p. 33-45

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Extraction and detection of Ionophores in the Aquatic Environment

    Bak, S. A., Hansen, M., Krogh, K. A., Björklund, E. & Halling-Sørensen, B., 17 May 2011.

    Research output: Contribution to conferencePosterResearch

  11. Published

    Design, synthesis, and pharmacological characterization of novel spirocyclic quinuclidinyl-Delta2 -isoxazoline derivatives as potent and selective agonists of alpha7 nicotinic acetylcholine receptors

    Dallanoce, C., Magrone, P., Matera, C., Frigerio, F., Grazioso, G., De Amici, M., Fucile, S., Piccari, V., Frydenvang, Karla Andrea, Pucci, L., Gotti, C., Clementi, F. & De Micheli, C., 2 May 2011, In : ChemMedChem. 6, 5, p. 889-903

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Thapsigargin affinity purification of intracellular P2A-type Ca2+ ATPases

    Vandecaetsbeek, I., Christensen, Søren Brøgger, Liu, H., van Veldhoven, P. P., Waelkens, E., Eggermont, J., Raeymaekers, L., Møller, J. V., Nissen, P., Wuytack, F. & Vangheluwe, P., 1 May 2011, In : BBA General Subjects. 1813, 5, p. 1118-1127

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    1,2,3-triazoles in peptidomimetic chemistry

    Pedersen, D. S. & Abell, A., May 2011, In : European Journal of Organic Chemistry. 2011, 13, p. 2399-2411

    Research output: Contribution to journalReviewResearchpeer-review

  14. Published

    New insights into the GABAA receptor structure and orthosteric ligand binding: Receptor modeling guided by experimental data

    Sander, T., Frølund, Bente, Bruun, A. T., Ivanov, I., McCammon, J. A. & Balle, T., May 2011, In : Proteins: Structure, Function, and Bioinformatics. 79, 5, p. 1458-1477

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Studies of monoamine transporters: Phosphorylation of the serotonin transporter and interactions of antidepressants with the serotonin and norepinephrine transporters

    Sørensen, L., May 2011, København: Det Farmaceutiske Fakultet. 174 p.

    Research output: Book/ReportPh.D. thesisResearch

  16. Published

    X-ray crystal structure and small-angle X-ray scattering of sheep liver sorbitol dehydrogenase

    Yennawar, H., Møller, M., Gillilan, R. & Yennawar, N., May 2011, In : Acta Crystallographica. Section D: Biological Crystallography. 67, Pt 5, p. 440-446

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Comparative pharmacokinetics between a microdose and therapeutic dose for clarithromycin, sumatriptan, propafenone, paracetamol (acetaminophen) and phenobarbital in human volunteers

    Lappin, G., Shishikura, Y., Jochemsen, R., Weaver, R. J., Gesson, C., Houston, J. B., Oosterhuis, B., Bjerrum, Ole Jannik, Grynkiewicz, G., Alder, J., Rowland, M. & Garner, C., 20 Apr 2011, In : European Journal of Pharmaceutical Sciences. 43, 3, p. 141-150 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Pharmacological properties of Anagallis arvensis L. ("scarlet pimpernel") and Anagallis foemina Mill. ("blue pimpernel") traditionally used as wound healing remedies in Navarra (Spain)

    López, V., Jäger, A. K., Akerreta, S., Cavero, R. Y. & Calvo, M. I., 12 Apr 2011, In : Journal of Ethnopharmacology. 134, 3, p. 1014-1017

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Electrophilic organic selenium reagents: protonated seleninic acids as precursors for unsymmetrical aromatic selenides

    Stuhr-Hansen, N., Sølling, Theis Ivan & Henriksen, L., 8 Apr 2011, In : Tetrahedron. 67, 14, p. 2633-2643

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    ZP2307, a novel cyclic PTH(1-17) analog, reversed established osteopenia in adult ovariectomized rats

    Vääräniemi, J., Morko, J., Peng, Z., Rissanen, J. P., Suominen, M. I., Fagerlund, K. M., Suutari, T. A., Boonen, Harrie C.M., Neerup, T. S., Bak, H. H. & Halleen, J. M., 7 Apr 2011. 1 p.

    Research output: Contribution to conferencePosterResearch

  21. Published

    Discovery of benzamide analogues as a novel class of 5-HT3 receptor agonists

    Jørgensen, C. G., Frølund, Bente, Kehler, J. & Jensen, Anders A., 4 Apr 2011, In : ChemMedChem. 6, 4, p. 725-736

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Amaryllidaceae alkaloids from the Australasian tribe Calostemmateae with acetylcholinesterase inhibitory activity

    Søvsø Jensen, B., Christensen, Søren Brøgger, Jäger, A. K. & Rønsted, Nina, Apr 2011, In : Biochemical Systematics and Ecology. 39, 2, p. 153-155

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Glutamate receptor agonists: stereochemical aspects

    Vogensen, S. B., Greenwood, J. R., Bunch, Lennart & Clausen, Rasmus Prætorius, Apr 2011, In : Current Topics in Medicinal Chemistry. 11, 7, p. 887-906

    Research output: Contribution to journalReviewResearchpeer-review

  24. Published

    Cell-permeable and plasma-stable peptidomimetic inhibitors of the postsynaptic density-95/N-methyl-D-aspartate receptor interaction

    Bach, Anders, Eildal, J. N. N., Stuhr-Hansen, N., Deeskamp, R., Gottschalk, M., Pedersen, S. W., Kristensen, Anders Skov & Strømgaard, Kristian, 10 Mar 2011, In : Journal of Medicinal Chemistry. 54, 5, p. 1333-1346

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    European new safe and innovative medicines initiatives: history and progress (through December 2009)

    Bjerrum, Ole Jannik & H. Linden, H., Mar 2011, Translational medicine and drug discovery. Cambridge: Cambridge University Press, p. 265-288 23 p.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterCommunication

  26. Published

    Metabolic profiling of Rhodiola rosea rhizomes by 1H NMR spectroscopy

    Ioset, K. N., Nyberg, N. T., Van Diermen, D., Malnoe, P., Hostettmann, K., Shikov, A. N. & Jaroszewski, J. W., Mar 2011, In : Phytochemical Analysis. 22, 2, p. 158-165

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    G protein- and agonist-bound serotonin 5-HT2A receptor model activated by steered molecular dynamics simulations

    Ísberg, V., Balle, T., Sander, T., Jørgensen, Flemming Steen & Gloriam, David E., 28 Feb 2011, In : Journal of Chemical Information and Modeling. 51, 2, p. 315-325

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Human phenotypically distinct TGFBI corneal dystrophies are linked to the stability of the fourth FAS1 domain of TGFBIp

    Runager, K., Basaiawmoit, R. V., Deva, T., Andreasen, M., Valnickova, Z., Sørensen, C. S., Karring, H., Thøgersen, I. B., Christiansen, G., Underhaug, J., Kristensen, T., Nielsen, N. C., Klintworth, G. K., Otzen, D. E. & Enghild, J. J., 18 Feb 2011, In : The Journal of Biological Chemistry. 286, 7, p. 4951-4958

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Medicinal chemistry of competitive kainate receptor antagonists

    Larsen, A. M. & Bunch, Lennart, 16 Feb 2011, In : ACS Chemical Neuroscience. 2, 2, p. 60-74

    Research output: Contribution to journalReviewResearchpeer-review

  30. Published

    Flavonoids and the CNS

    Jäger, A. K. & Saaby, L., 10 Feb 2011, In : Molecules. 16, 2, p. 1471-1485

    Research output: Contribution to journalReviewResearchpeer-review

  31. Published

    Functional and structural studies of neuronal D-serine transporter Asc1

    Wang, X., 10 Feb 2011, København: Det Farmaceutiske Fakultet. 148 p.

    Research output: Book/ReportPh.D. thesisResearch

  32. Published

    Expedient synthesis of 1,3-substituted benzene peptidomimetics

    Bach, Anders & Strømgaard, Kristian, 8 Feb 2011, In : Synthesis. 2011, 5, p. 807-815

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Biophysical characterization of the complex between human papillomavirus E6 protein and synapse-associated protein 97

    Chi, C. N., Bach, Anders, Engström, Å., Strømgaard, Kristian, Lundström, P., Ferguson, N. & Jemth, P., 4 Feb 2011, In : Journal of Biological Chemistry. 286, 5, p. 3597-3606

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Synthesis of new isoxazoline-based acidic amino acids and investigation of their affinity and selectivity profile at ionotropic glutamate receptors

    Pinto, A., Conti, P., Grazioso, G., Tamborini, L., Madsen, Ulf, Nielsen, Birgitte & De Micheli, C., 1 Feb 2011, In : European Journal of Medicinal Chemistry. 46, 2, p. 787-793

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published
  36. Published

    Isolation of immunomodulatory triterpene acids from a standardized rose hip powder (Rosa canina L.)

    Saaby, L., Jäger, A. K., Moesby, L., Hansen, E. W. & Christensen, Søren Brøgger, Feb 2011, In : Phytotherapy Research. 25, 2, p. 195-201

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    The minor C-allele of rs2014355 in ACADS is associated with reduced insulin release following an oral glucose load

    Hornbak, M., Banasik, Karina, Justesen, Johanne Marie, Krarup, N. T., Sandholt, C. H., Andersson, Å., Sandbaek, A., Lauritzen, T., Pisinger, Charlotta Holm, Witte, D. R., Sørensen, Thorkild I.A., Pedersen, Oluf Borbye & Hansen, Torben, 6 Jan 2011, In : BMC Medical Genetics. 12, 1, p. 4 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Lessons from more than 80 structures of the GluA2 ligand-binding domain in complex with agonists, antagonists and allosteric modulators

    Pøhlsgaard, J., Frydenvang, Karla Andrea, Madsen, Ulf & Kastrup, Jette Sandholm Jensen, 1 Jan 2011, In : Neuropharmacology. 60, 1, p. 135-150

    Research output: Contribution to journalReviewResearchpeer-review

  39. Published

    Potentiating action of propofol at GABAA receptors of retinal bipolar cells

    Yue, L., Xie, A., Bruzik, K. S., Frølund, Bente, Qian, H. & Pepperberg, D. R., 1 Jan 2011, In : Investigative Ophthalmology & Visual Science. 52, 5, p. 2497-2509

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Purification, crystallization and preliminary X-ray diffraction of the G3BP1 NTF2-like domain

    Vognsen, T., Möller, Ingvar Rúnar & Kristensen, O., 1 Jan 2011, In : Acta Crystallographica. Section F: Structural Biology and Crystallization Communications Online. 67, Pt 1, p. 48-50

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Triazoloquinazolinediones as novel high affinity ligands for the benzodiazepine site of GABA(A) receptors

    Nilsson, J., Gidlöf, R., Nielsen, E. Ø., Liljefors, T., Nielsen, M. P. C. & Sterner, O., 1 Jan 2011, In : Bioorganic & Medicinal Chemistry. 19, 1, p. 111-121

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Effects of bile on the oral absorption of poorly water-soluble drugs in rats

    Tønsberg, H., Jan 2011, København: Det Farmaceutiske Fakultetsbibliotek, Det Farmaceutiske Fakultet, Københavns Universitet. 83 p.

    Research output: Book/ReportPh.D. thesisResearch

  43. Published

    On-chip electro membrane extraction with online ultaviolet and mass spectrometric detection

    Petersen, Nickolaj J., Foss, S. T., Jensen, H., Hansen, S. H., Skonberg, C., Snakenborg, D., Kutter, J. P. & Pedersen-Bjergaard, Stig, Jan 2011, In : Analytical Chemistry. 83, 1, p. 44-51

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    (Eco)teoxicological effects of transformation products: (Not) a research question ?

    Hansen, M., 2011.

    Research output: Working paperResearch

  45. Published

    1H NMR- and HPLC-based metabolomics combined with hyphenated HPLC-SPE-NMR methods for the investigation of herbal remedies and medicinal plants

    Agnolet, Sara, 2011, København: Det Farmaceutiske Fakultet.

    Research output: Book/ReportPh.D. thesisResearch

  46. Published

    2-Oleoyl glycerol is a GPR119 agonist and signals GLP-1 release in humans

    Hansen, K. B., Rosenkilde, Mette, Knop, Filip Krag, Wellner, N., Diep, T. A., Rehfeld, Jens Frederik, Andersen, U. B., Holst, Jens Juul & Hansen, Harald S., 2011, In : Journal of Clinical Endocrinology and Metabolism. 96, 9, p. E1409-17

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    In vitro penetration properties of solid lipid nanoparticles in intact and barrier-impaired skin

    Jensen, L. B., Petersson, K. & Nielsen, Hanne Mørck, 2011, In : European Journal of Pharmaceutics and Biopharmaceutics. 79, 1, p. 68-75

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    A ligand's view of target similarity: chemogenomic binding site-directed techniques for drug discovery

    Garland, S. L. & Gloriam, David E., 2011, In : Current Topics in Medicinal Chemistry. 11, 15, p. 1872-1881

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    A model on the carbon cycling in Lake Taihu, China

    Weiping, H., Jørgensen, S. E., Fabing, Z., Yonggen, C., Zhixin, H. & Longyuan, Y., 2011, In : Ecological Modelling. 222, 16, p. 2973-2991

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    A novel excipient, 1-perfluorohexyloctane shows limited utility for the oral delivery of poorly water-soluble drugs

    Holm, R., Jørgensen, E. B., Harborg, M., Larsen, R. S., Holm, P., Mullertz, Anette & Jacobsen, Jette, 2011, In : European Journal of Pharmaceutical Sciences. 42, p. 416-422

    Research output: Contribution to journalJournal articleResearchpeer-review

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