DNA incorporation of 6-thioguanine nucleotides during maintenance therapy of childhood acute lymphoblastic leukaemia and non-Hodgkin lymphoma
Research output: Contribution to journal › Journal article › Research › peer-review
To explore the DNA incorporation of 6-thioguanine nucleotide levels (DNA-6TGN) during 6-mercaptopurine (6MP) therapy of childhood acute lymphoblastic leukaemia (ALL) and non-Hodgkin lymphoma (NHL) and its relation to erythrocyte levels of their metabolites: 6-thioguanine-nucleotides (E-6TGN), methylated metabolites (E-MeMP), Methotrexate polyglutamates (E-MTX), and to thiopurine methyltransferase activity (TPMT).
| Original language | English |
|---|---|
| Journal | Cancer Chemotherapy and Pharmacology |
| Volume | 66 |
| Issue number | 3 |
| Pages (from-to) | 485-91 |
| Number of pages | 7 |
| ISSN | 0344-5704 |
| DOIs | |
| Publication status | Published - 1 Aug 2010 |
- 6-Mercaptopurine, Antineoplastic Combined Chemotherapy Protocols, Child, Child, Preschool, Cytosol, DNA, Drug Monitoring, Erythrocytes, Female, Guanine Nucleotides, Humans, Infant, Lymphoma, Non-Hodgkin, Male, Methotrexate, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Purines, Thionucleotides
Research areas
ID: 33769619