Elemental Constituents of Particulate Matter and Newborn's Size in Eight European Cohorts

Research output: Contribution to journalJournal articleResearchpeer-review

Marie Pedersen, Ulrike Gehring, Rob Beelen, Meng Wang, Lise Giorgis-Allemand, Anne-Marie Nybo Andersen, Xavier Basagaña, Claire Bernard, Marta Cirach, Francesco Forastiere, Kees de Hoogh, Regina Gražulevičienė, Olena Gruzieva, Gerard Hoek, Aleksandra Jedynska, Claudia Klümper, Ingeborg M Kooter, Ursula Krämer, Jaakko Kukkonen, Daniela Porta & 13 more Dirkje S Postma, Ole Raaschou-Nielsen, Lenie van Rossem, Jordi Sunyer, Mette Sørensen, Ming-Yi Tsai, Tanja G Vrijkotte, Michael Wilhelm, Mark J Nieuwenhuijsen, Göran Pershagen, Bert Brunekreef, Manolis Kogevinas, Rémy Slama

BACKGROUND: The health effects of suspended particulate matter (PM) may depend on its chemical composition. Associations between maternal exposure to chemical constituents of PM and newborn's size have been little examined.

AIM: We aimed to investigate the associations of exposure to elemental constituents of PM with term low birth weight (LBW, weight<2,500 g among births after 37 weeks of gestation), mean birth weight and head circumference, relying on standardised fine-scale exposure assessment and with extensive control for potential confounders.

METHODS: We pooled data from eight European cohorts comprising 34,923 singleton births in 1994-2008. Annual average concentrations of elemental constituents of PM smaller than 2.5 and 10 µm (PM2.5 and PM10) at maternal home addresses during pregnancy were estimated using land-use regression models. Adjusted associations between each birth measurement and concentrations of eight elements (copper, iron, potassium, nickel, sulfur, silicon, vanadium and zinc) were calculated using random-effects regression on pooled data.

RESULTS: A 200 ng/m(3) increase in sulfur in PM2.5 was associated with an increased risk of LBW (adjusted odds ratio, 1.36, 95% confidence interval: 1.17, 1.58). Increased nickel and zinc in PM2.5 concentrations were also associated with an increased risk of LBW. Head circumference was reduced at higher exposure to all elements except potassium. All associations with sulfur were most robust to adjustment for PM2.5 mass concentration. All results were similar for PM10.

CONCLUSION: Sulfur, reflecting secondary combustion particles in this study, may adversely affect LBW and head circumference, independently of particle mass.

Original languageEnglish
JournalEnvironmental Health Perspectives
Volume124
Issue number1
Pages (from-to)141-150
Number of pages10
ISSN0091-6765
DOIs
Publication statusPublished - Jan 2016

ID: 143933986