Infant Feeding and Risk of Type 1 Diabetes in Two Large Scandinavian Birth Cohorts

Research output: Contribution to journalJournal articleResearchpeer-review

  • Nicolai A. Lund-Blix
  • Stine Dydensborg Sander
  • Ketil Størdal
  • Nybo Andersen, Anne-Marie
  • Kjersti S. Rønningen
  • Geir Joner
  • Torild Skrivarhaug
  • Pal R. Njølstad
  • Steffen Husby
  • Lars C. Stene
OBJECTIVE: Our aim was to study the relation between the duration of full and any breastfeeding and risk of type 1 diabetes.

RESEARCH DESIGN AND METHODS: We included two population-based cohorts of children followed from birth (1996–2009) to 2014 (Denmark) or 2015 (Norway). We analyzed data from a total of 155,392 children participating in the Norwegian Mother and Child Cohort Study (MoBa) and the Danish National Birth Cohort (DNBC). Parents reported infant dietary practices when their child was 6 and 18 months old. The outcome was clinical type 1 diabetes, ascertained from nationwide childhood diabetes registries. Hazard ratios (HRs) were estimated using Cox regression.

RESULTS: Type 1 diabetes was identified in 504 children during follow-up, and the incidence of type 1 diabetes per 100,000 person-years was 30.5 in the Norwegian cohort and 23.5 in the Danish cohort. Children who were never breastfed had a twofold increased risk of type 1 diabetes compared with those who were breastfed (HR 2.29 [95% CI 1.14–4.61] for no breastfeeding vs. any breastfeeding for ≥12 months). Among those who were breastfed, however, the incidence of type 1 diabetes was independent of duration of both full breastfeeding (HR per month 0.99 [95% CI 0.97–1.01]) and any breastfeeding (0.97 [0.92–1.03]).

CONCLUSIONS: Suggestive evidence supports the contention that breastfeeding reduces the risk of type 1 diabetes. Among those who were breastfed, however, no evidence indicated that prolonging full or any breastfeeding was associated with a reduced risk of type 1 diabetes.
Original languageEnglish
JournalDiabetes Care
Issue number7
Pages (from-to)920-927
Number of pages8
Publication statusPublished - Jul 2017

ID: 188197324