Intergenerational transmission of tobacco smoking: The role of the child's behavioral difficulties. Data from the Danish National Birth cohort (DNBC)
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Intergenerational transmission of tobacco smoking : The role of the child's behavioral difficulties. Data from the Danish National Birth cohort (DNBC). / Fekom, Mathilde; Nguyen, Tri-Long; Lepeule, Johanna; Nakamura, Aurélie; Keyes, Katherine; Martins, Silvia; Strandberg-Larsen, Katrine; Melchior, Maria.
In: Drug and Alcohol Dependence, Vol. 255, 111056, 2024.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Intergenerational transmission of tobacco smoking
T2 - The role of the child's behavioral difficulties. Data from the Danish National Birth cohort (DNBC)
AU - Fekom, Mathilde
AU - Nguyen, Tri-Long
AU - Lepeule, Johanna
AU - Nakamura, Aurélie
AU - Keyes, Katherine
AU - Martins, Silvia
AU - Strandberg-Larsen, Katrine
AU - Melchior, Maria
N1 - Copyright © 2023 Elsevier B.V. All rights reserved.
PY - 2024
Y1 - 2024
N2 - AIMS: This study explores the role of offspring behavioral difficulties in the intergeneration transmission of tobacco smoking.METHODS: This longitudinal cohort study is based on children born in Denmark in 1996-2003 participating in the Danish National Birth Cohort (DNBC), followed-up until 18years of age. We included mother-child pairs with complete data regarding the exposure (4 trajectories of maternal daily smoking quantity during pregnancy: low, intermediate/stable, intermediate/decreasing and high), outcome (offspring daily smoking status at 18 years) and mediator (offspring symptoms of hyperactivity-inattention at 11 years), that is 24,588 mother-child pairs.RESULTS: In our study population, during pregnancy respectively 86.2%, 6.80%, 4.08% and 2.97% mothers belonged to the low, intermediate/stable, intermediate/decreasing and high smoking trajectory groups. After controlling for covariates using propensity scores, the direct effect of maternal smoking in pregnancy on offspring smoking in adolescence was statistically significant, especially when the mother belonged to the intermediate/stable smoking trajectory group (ORIPW = 2.09, 95% CI: 1.70 - 2.61) or to the high smoking trajectory group (ORIPW = 2.08, 95% CI: 1.52 - 3.11) compared to the low smoking trajectory group. None of the indirect effects of maternal smoking in pregnancy were statistically significant, and neither were the proportions mediated.CONCLUSION: Maternal pregnancy smoking seems to have an influence on offspring smoking in early adulthood, which does not appear to be mediated by offspring behavioral difficulties. Women should be strongly encouraged to quit smoking in pregnancy to reduce both short and long-term health risks among their offspring.
AB - AIMS: This study explores the role of offspring behavioral difficulties in the intergeneration transmission of tobacco smoking.METHODS: This longitudinal cohort study is based on children born in Denmark in 1996-2003 participating in the Danish National Birth Cohort (DNBC), followed-up until 18years of age. We included mother-child pairs with complete data regarding the exposure (4 trajectories of maternal daily smoking quantity during pregnancy: low, intermediate/stable, intermediate/decreasing and high), outcome (offspring daily smoking status at 18 years) and mediator (offspring symptoms of hyperactivity-inattention at 11 years), that is 24,588 mother-child pairs.RESULTS: In our study population, during pregnancy respectively 86.2%, 6.80%, 4.08% and 2.97% mothers belonged to the low, intermediate/stable, intermediate/decreasing and high smoking trajectory groups. After controlling for covariates using propensity scores, the direct effect of maternal smoking in pregnancy on offspring smoking in adolescence was statistically significant, especially when the mother belonged to the intermediate/stable smoking trajectory group (ORIPW = 2.09, 95% CI: 1.70 - 2.61) or to the high smoking trajectory group (ORIPW = 2.08, 95% CI: 1.52 - 3.11) compared to the low smoking trajectory group. None of the indirect effects of maternal smoking in pregnancy were statistically significant, and neither were the proportions mediated.CONCLUSION: Maternal pregnancy smoking seems to have an influence on offspring smoking in early adulthood, which does not appear to be mediated by offspring behavioral difficulties. Women should be strongly encouraged to quit smoking in pregnancy to reduce both short and long-term health risks among their offspring.
KW - Pregnancy
KW - Adolescent
KW - Humans
KW - Female
KW - Adult
KW - Longitudinal Studies
KW - Birth Cohort
KW - Prenatal Exposure Delayed Effects/epidemiology
KW - Tobacco Smoking
KW - Mothers
KW - Denmark/epidemiology
U2 - 10.1016/j.drugalcdep.2023.111056
DO - 10.1016/j.drugalcdep.2023.111056
M3 - Journal article
C2 - 38128363
VL - 255
JO - Drug and Alcohol Dependence
JF - Drug and Alcohol Dependence
SN - 0376-8716
M1 - 111056
ER -
ID: 381458289