Matched survival data in a co-twin control design

Research output: Contribution to journalJournal articleResearchpeer-review

When using the co-twin control design for analysis of event times, one needs a model to address the possible within-pair association. One such model is the shared frailty model in which the random frailty variable creates the desired within-pair association. Standard inference for this model requires independence between the random effect and the covariates. We study how violations of this assumption affect inference for the regression coefficients and conclude that substantial bias may occur. We propose an alternative way of making inference for the regression parameters by using a fixed-effects models for survival in matched pairs. Fitting this model to data generated from the frailty model provides consistent and asymptotically normal estimates of regression coefficients, no matter whether the independence assumption is met.

Original languageEnglish
JournalLifetime Data Analysis
Volume20
Issue number1
Pages (from-to)38-50
Number of pages13
ISSN1380-7870
DOIs
Publication statusPublished - Jan 2014

    Research areas

  • Bias (Epidemiology), Computer Simulation, Humans, Models, Statistical, Research Design, Twin Studies as Topic

ID: 135437326