Maternal occupation during pregnancy, birth weight, and length of gestation: combined analysis of 13 European birth cohorts
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Maternal occupation during pregnancy, birth weight, and length of gestation : combined analysis of 13 European birth cohorts. / Casas, Maribel; Cordier, Sylvaine; Martínez, David; Barros, Henrique; Bonde, Jens Peter; Burdorf, Alex; Costet, Nathalie; Dos Santos, Ana Cristina; Danileviciute, Asta; Eggesbø, Merete; Fernandez, Mariana; Fevotte, Joelle; García, Ana M; Gražuleviciene, Regina; Hallner, Eva; Hanke, Wojciech; Kogevinas, Manolis; Kull, Inger; Stemann Larsen, Pernille; Melaki, Vasiliki; Monfort, Christine; Nordby, Karl-Christian; Nybo Andersen, Anne-Marie; Patelarou, Evridiki; Polanska, Kinga; Richiardi, Lorenzo; Santa Marina, Loreto; Snijder, Claudia; Tardón, Adonina; van Eijsden, Manon; Vrijkotte, Tanja G M; Zugna, Daniela; Nieuwenhuijsen, Mark; Vrijheid, Martine.
In: Scandinavian Journal of Work, Environment & Health, Vol. 41, No. 4, 07.2015, p. 384-396.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Maternal occupation during pregnancy, birth weight, and length of gestation
T2 - combined analysis of 13 European birth cohorts
AU - Casas, Maribel
AU - Cordier, Sylvaine
AU - Martínez, David
AU - Barros, Henrique
AU - Bonde, Jens Peter
AU - Burdorf, Alex
AU - Costet, Nathalie
AU - Dos Santos, Ana Cristina
AU - Danileviciute, Asta
AU - Eggesbø, Merete
AU - Fernandez, Mariana
AU - Fevotte, Joelle
AU - García, Ana M
AU - Gražuleviciene, Regina
AU - Hallner, Eva
AU - Hanke, Wojciech
AU - Kogevinas, Manolis
AU - Kull, Inger
AU - Stemann Larsen, Pernille
AU - Melaki, Vasiliki
AU - Monfort, Christine
AU - Nordby, Karl-Christian
AU - Nybo Andersen, Anne-Marie
AU - Patelarou, Evridiki
AU - Polanska, Kinga
AU - Richiardi, Lorenzo
AU - Santa Marina, Loreto
AU - Snijder, Claudia
AU - Tardón, Adonina
AU - van Eijsden, Manon
AU - Vrijkotte, Tanja G M
AU - Zugna, Daniela
AU - Nieuwenhuijsen, Mark
AU - Vrijheid, Martine
PY - 2015/7
Y1 - 2015/7
N2 - OBJECTIVES: We assessed whether maternal employment during pregnancy - overall and in selected occupational sectors - is associated with birth weight, small for gestational age (SGA), term low birth weight (LBW), length of gestation, and preterm delivery in a population-based birth cohort design.METHODS: We used data from >200 000 mother-child pairs enrolled in 13 European birth cohorts and compared employed versus non-employed women. Among employees, we defined groups of occupations representing the main sectors of employment for women where potential reproductive hazards are considered to be present. The comparison group comprised all other employed women not included in the occupational sector being assessed. We performed meta-analyses of cohort-specific estimates and explored heterogeneity.RESULTS: Employees had a lower risk of preterm delivery than non-employees [adjusted odds ratio (ORadj) 0.86, 95% confidence interval (95% CI) 0.81-0.91]. Working in most of the occupational sectors studied was not associated with adverse birth outcomes. Being employed as a nurse was associated with lower risk SGA infants (ORadj 0.91, 95% CI 0.84-0.99) whereas food industry workers had an increased risk of preterm delivery (ORadj 1.50, 95% CI 1.12-2.02). There was little evidence for heterogeneity between cohorts.CONCLUSIONS: This study suggests that, overall, employment during pregnancy is associated with a reduction in the risk of preterm birth and that work in certain occupations may affect pregnancy outcomes. This exploratory study provides an important platform on which to base further prospective studies focused on the potential consequences of maternal occupational exposures during pregnancy on child development.
AB - OBJECTIVES: We assessed whether maternal employment during pregnancy - overall and in selected occupational sectors - is associated with birth weight, small for gestational age (SGA), term low birth weight (LBW), length of gestation, and preterm delivery in a population-based birth cohort design.METHODS: We used data from >200 000 mother-child pairs enrolled in 13 European birth cohorts and compared employed versus non-employed women. Among employees, we defined groups of occupations representing the main sectors of employment for women where potential reproductive hazards are considered to be present. The comparison group comprised all other employed women not included in the occupational sector being assessed. We performed meta-analyses of cohort-specific estimates and explored heterogeneity.RESULTS: Employees had a lower risk of preterm delivery than non-employees [adjusted odds ratio (ORadj) 0.86, 95% confidence interval (95% CI) 0.81-0.91]. Working in most of the occupational sectors studied was not associated with adverse birth outcomes. Being employed as a nurse was associated with lower risk SGA infants (ORadj 0.91, 95% CI 0.84-0.99) whereas food industry workers had an increased risk of preterm delivery (ORadj 1.50, 95% CI 1.12-2.02). There was little evidence for heterogeneity between cohorts.CONCLUSIONS: This study suggests that, overall, employment during pregnancy is associated with a reduction in the risk of preterm birth and that work in certain occupations may affect pregnancy outcomes. This exploratory study provides an important platform on which to base further prospective studies focused on the potential consequences of maternal occupational exposures during pregnancy on child development.
KW - Birth Weight
KW - Cohort Studies
KW - Employment
KW - Europe
KW - Female
KW - Gestational Age
KW - Health Behavior
KW - Humans
KW - Infant, Low Birth Weight
KW - Infant, Newborn
KW - Infant, Small for Gestational Age
KW - Maternal Exposure
KW - Meta-Analysis as Topic
KW - Occupations
KW - Pregnancy
KW - Pregnancy Outcome
KW - Premature Birth
KW - Regression Analysis
KW - Risk Factors
KW - Surveys and Questionnaires
U2 - 10.5271/sjweh.3500
DO - 10.5271/sjweh.3500
M3 - Journal article
C2 - 25940455
VL - 41
SP - 384
EP - 396
JO - Scandinavian Journal of Work, Environment & Health
JF - Scandinavian Journal of Work, Environment & Health
SN - 0355-3140
IS - 4
ER -
ID: 160098822