TY - JOUR

T1 - Maternal smoking during pregnancy and offspring overweight

T2 - is there a dose-response relationship? An individual patient data meta-analysis

AU - Albers, Lucia

AU - Sobotzki, Christina

AU - Kuß, Oliver

AU - Ajslev, Teresa

AU - Batista, Rosangela Fl

AU - Bettiol, Heloisa

AU - Brabin, Bernard

AU - Buka, Stephen L

AU - Cardoso, Viviane C

AU - Clifton, Vicki L

AU - Devereux, Graham

AU - Gilman, Stephen E

AU - Grzeskowiak, Luke E

AU - Heinrich, Joachim

AU - Hummel, Sandra

AU - Jacobsen, Geir W

AU - Jones, Graeme

AU - Koshy, Gibby

AU - Morgen, Camilla Schmidt

AU - Oken, Emily

AU - Paus, Tomas

AU - Pausova, Zdenka

AU - Rifas-Shiman, Sheryl L

AU - Sharma, Andrea J

AU - da Silva, Antônio Am

AU - Sørensen, Thorkild Ia

AU - Thiering, Elisabeth

AU - Turner, Stephen

AU - Vik, Torstein

AU - von Kries, Rüdiger

PY - 2018

Y1 - 2018

N2 - BACKGROUND/OBJECTIVES: A number of meta-analyses suggest an association between any maternal smoking in pregnancy and offspring overweight obesity. Whether there is a dose-response relationship across number of cigarettes and whether this differs by sex remains unclear.SUBJECT/METHODS: Studies reporting number of cigarettes smoked during pregnancy and offspring BMI published up to May 2015 were searched. An individual patient data meta-analysis of association between the number of cigarettes smoked during pregnancy and offspring overweight (defined according to the International Obesity Task Force reference) was computed using a generalized additive mixed model with non-linear effects and adjustment for confounders (maternal weight status, breastfeeding, and maternal education) and stratification for sex.RESULTS: Of 26 identified studies, 16 authors provided data on a total of 238,340 mother-child-pairs. A linear positive association was observed between the number of cigarettes smoked and offspring overweight for up to 15 cigarettes per day with an OR increase per cigarette of 1.03, 95% CI = [1.02-1.03]. The OR flattened with higher cigarette use. Associations were similar in males and females. Sensitivity analyses supported these results.CONCLUSIONS: A linear dose-response relationship of maternal smoking was observed in the range of 1-15 cigarettes per day equally in boys and girls with no further risk increase for doses above 15 cigarettes.

AB - BACKGROUND/OBJECTIVES: A number of meta-analyses suggest an association between any maternal smoking in pregnancy and offspring overweight obesity. Whether there is a dose-response relationship across number of cigarettes and whether this differs by sex remains unclear.SUBJECT/METHODS: Studies reporting number of cigarettes smoked during pregnancy and offspring BMI published up to May 2015 were searched. An individual patient data meta-analysis of association between the number of cigarettes smoked during pregnancy and offspring overweight (defined according to the International Obesity Task Force reference) was computed using a generalized additive mixed model with non-linear effects and adjustment for confounders (maternal weight status, breastfeeding, and maternal education) and stratification for sex.RESULTS: Of 26 identified studies, 16 authors provided data on a total of 238,340 mother-child-pairs. A linear positive association was observed between the number of cigarettes smoked and offspring overweight for up to 15 cigarettes per day with an OR increase per cigarette of 1.03, 95% CI = [1.02-1.03]. The OR flattened with higher cigarette use. Associations were similar in males and females. Sensitivity analyses supported these results.CONCLUSIONS: A linear dose-response relationship of maternal smoking was observed in the range of 1-15 cigarettes per day equally in boys and girls with no further risk increase for doses above 15 cigarettes.

U2 - 10.1038/s41366-018-0050-0

DO - 10.1038/s41366-018-0050-0

M3 - Journal article

C2 - 29717267

VL - 42

SP - 1249

EP - 1264

JO - International Journal of Obesity

JF - International Journal of Obesity

SN - 0307-0565

ER -