Non-replication of genome-wide based associations between common variants in INSIG2 and PFKP and obesity in studies of 18,014 Danes
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Non-replication of genome-wide based associations between common variants in INSIG2 and PFKP and obesity in studies of 18,014 Danes. / Sandholt, Camilla Helene; Mogensen, Mette S; Borch-Johnsen, Knut; Sandbaek, Annelli; Lauritzen, Torsten; Sørensen, Thorkild I A; Hansen, Lars; Almind, Katrine; Jørgensen, Torben; Pedersen, Oluf; Hansen, Torben.
In: PLoS ONE, Vol. 3, No. 8, 2008, p. e2872.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Non-replication of genome-wide based associations between common variants in INSIG2 and PFKP and obesity in studies of 18,014 Danes
AU - Sandholt, Camilla Helene
AU - Mogensen, Mette S
AU - Borch-Johnsen, Knut
AU - Sandbaek, Annelli
AU - Lauritzen, Torsten
AU - Sørensen, Thorkild I A
AU - Hansen, Lars
AU - Almind, Katrine
AU - Jørgensen, Torben
AU - Pedersen, Oluf
AU - Hansen, Torben
PY - 2008
Y1 - 2008
N2 - The INSIG2 rs7566605 and PFKP rs6602024 polymorphisms have been identified as obesity gene variants in genome-wide association (GWA) studies. However, replication has been contradictory for both variants. The aims of this study were to validate these obesity-associations through case-control studies and analyses of obesity-related quantitative traits. Moreover, since environmental and genetic factors may modulate the impact of a genetic variant, we wanted to perform such interaction analyses. We focused on physical activity as an environmental risk factor, and on the GWA identified obesity variants in FTO (rs9939609) and near MC4R (rs17782313) as genetic risk factors.
AB - The INSIG2 rs7566605 and PFKP rs6602024 polymorphisms have been identified as obesity gene variants in genome-wide association (GWA) studies. However, replication has been contradictory for both variants. The aims of this study were to validate these obesity-associations through case-control studies and analyses of obesity-related quantitative traits. Moreover, since environmental and genetic factors may modulate the impact of a genetic variant, we wanted to perform such interaction analyses. We focused on physical activity as an environmental risk factor, and on the GWA identified obesity variants in FTO (rs9939609) and near MC4R (rs17782313) as genetic risk factors.
KW - Blood Platelets
KW - DNA Replication
KW - Denmark
KW - Exercise
KW - Female
KW - Genetic Variation
KW - Genome, Human
KW - Genotype
KW - Humans
KW - Intracellular Signaling Peptides and Proteins
KW - Male
KW - Membrane Proteins
KW - Motor Activity
KW - Obesity
KW - Overweight
KW - Phosphofructokinases
KW - Polymorphism, Genetic
U2 - 10.1371/journal.pone.0002872
DO - 10.1371/journal.pone.0002872
M3 - Journal article
C2 - 18682847
VL - 3
SP - e2872
JO - PLoS ONE
JF - PLoS ONE
SN - 1932-6203
IS - 8
ER -
ID: 10854692