Studies of variability in the PTEN gene among Danish caucasian patients with Type II diabetes mellitus
Research output: Contribution to journal › Journal article › Research › peer-review
Phosphatase and tensin homologue deleted from chromosome ten (PTEN) has recently been characterized as a novel member in the expanding network of proteins regulating the intracellular effects of insulin. By dephosphorylation of phosphatidyl-inositol-(3, 4, 5)-trisphosphate (PIP3) the PTEN protein regulates the insulin-dependent phosphoinositide 3-kinase (PI3K) signalling cassette and accordingly might function as a regulator of insulin sensitivity in skeletal muscle and adipose tissue. In this study we tested PTEN as a candidate gene for insulin resistance and late-onset Type II (non-insulin-dependent) diabetes mellitus in a Danish Caucasian population.
| Original language | English |
|---|---|
| Journal | Diabetologia |
| Volume | 44 |
| Issue number | 2 |
| Pages (from-to) | 237-240 |
| Number of pages | 4 |
| ISSN | 0012-186X |
| DOIs | |
| Publication status | Published - Feb 2001 |
- Adipose Tissue, Adult, Aged, Blood Glucose, Blood Pressure, C-Peptide, Denmark, Diabetes Mellitus, Type 2, European Continental Ancestry Group, Exons, Fasting, Gene Frequency, Humans, Insulin, Insulin Resistance, Middle Aged, Muscle, Skeletal, PTEN Phosphohydrolase, Phosphatidylinositol 3-Kinases, Phosphatidylinositol Phosphates, Phosphoric Monoester Hydrolases, Polymerase Chain Reaction, Polymorphism, Genetic, Polymorphism, Restriction Fragment Length, Polymorphism, Single-Stranded Conformational, Tumor Suppressor Proteins
Research areas
ID: 96264