TY - JOUR

T1 - The CODATwins Project

T2 - The Cohort Description of Collaborative Project of Development of Anthropometrical Measures in Twins to Study Macro-Environmental Variation in Genetic and Environmental Effects on Anthropometric Traits

AU - Silventoinen, Karri

AU - Jelenkovic, Aline

AU - Sund, Reijo

AU - Honda, Chika

AU - Aaltonen, Sari

AU - Yokoyama, Yoshie

AU - Tarnoki, Adam D

AU - Tarnoki, David L

AU - Ning, Feng

AU - Ji, Fuling

AU - Pang, Zengchang

AU - Ordoñana, Juan R

AU - Sánchez-Romera, Juan F

AU - Colodro-Conde, Lucia

AU - Burt, S Alexandra

AU - Klump, Kelly L

AU - Medland, Sarah E

AU - Montgomery, Grant W

AU - Kandler, Christian

AU - McAdams, Tom A

AU - Eley, Thalia C

AU - Gregory, Alice M

AU - Saudino, Kimberly J

AU - Dubois, Lise

AU - Boivin, Michel

AU - Haworth, Claire M A

AU - Plomin, Robert

AU - Öncel, Sevgi Y

AU - Aliev, Fazil

AU - Stazi, Maria A

AU - Fagnani, Corrado

AU - D'Ippolito, Cristina

AU - Craig, Jeffrey M

AU - Saffery, Richard

AU - Siribaddana, Sisira H

AU - Hotopf, Matthew

AU - Sumathipala, Athula

AU - Spector, Timothy

AU - Mangino, Massimo

AU - Lachance, Genevieve

AU - Gatz, Margaret

AU - Butler, David A

AU - Bayasgalan, Gombojav

AU - Narandalai, Danshiitsoodol

AU - Freitas, Duarte L

AU - Maia, José Antonio

AU - Harden, K Paige

AU - Tucker-Drob, Elliot M

AU - Christensen, Kaare

AU - Skytthe, Axel

AU - Kyvik, Kirsten O

AU - Hong, Changhee

AU - Chong, Youngsook

AU - Derom, Catherine A

AU - Vlietinck, Robert F

AU - Loos, Ruth J F

AU - Cozen, Wendy

AU - Hwang, Amie E

AU - Mack, Thomas M

AU - He, Mingguang

AU - Ding, Xiaohu

AU - Chang, Billy

AU - Silberg, Judy L

AU - Eaves, Lindon J

AU - Maes, Hermine H

AU - Cutler, Tessa L

AU - Hopper, John L

AU - Aujard, Kelly

AU - Magnusson, Patrik K E

AU - Pedersen, Nancy L

AU - Aslan, Anna K Dahl

AU - Song, Yun-Mi

AU - Yang, Sarah

AU - Lee, Kayoung

AU - Baker, Laura A

AU - Tuvblad, Catherine

AU - Bjerregaard-Andersen, Morten

AU - Beck-Nielsen, Henning

AU - Sodemann, Morten

AU - Heikkilä, Kauko

AU - Tan, Qihua

AU - Zhang, Dongfeng

AU - Swan, Gary E

AU - Krasnow, Ruth

AU - Jang, Kerry L

AU - Knafo-Noam, Ariel

AU - Mankuta, David

AU - Abramson, Lior

AU - Lichtenstein, Paul

AU - Krueger, Robert F

AU - McGue, Matt

AU - Pahlen, Shandell

AU - Tynelius, Per

AU - Duncan, Glen E

AU - Buchwald, Dedra

AU - Corley, Robin P

AU - Huibregtse, Brooke M

AU - Nelson, Tracy L

AU - Whitfield, Keith E

AU - Franz, Carol E

AU - Kremen, William S

AU - Lyons, Michael J

AU - Ooki, Syuichi

AU - Brandt, Ingunn

AU - Nilsen, Thomas Sevenius

AU - Inui, Fujio

AU - Watanabe, Mikio

AU - Bartels, Meike

AU - van Beijsterveldt, Toos C E M

AU - Wardle, Jane

AU - Llewellyn, Clare H

AU - Fisher, Abigail

AU - Rebato, Esther

AU - Martin, Nicholas G

AU - Iwatani, Yoshinori

AU - Hayakawa, Kazuo

AU - Rasmussen, Finn

AU - Sung, Joohon

AU - Harris, Jennifer R

AU - Willemsen, Gonneke

AU - Busjahn, Andreas

AU - Goldberg, Jack H

AU - Boomsma, Dorret I

AU - Hur, Yoon-Mi

AU - Sørensen, Thorkild I A

AU - Kaprio, Jaakko

PY - 2015/8

Y1 - 2015/8

N2 - For over 100 years, the genetics of human anthropometric traits has attracted scientific interest. In particular, height and body mass index (BMI, calculated as kg/m2) have been under intensive genetic research. However, it is still largely unknown whether and how heritability estimates vary between human populations. Opportunities to address this question have increased recently because of the establishment of many new twin cohorts and the increasing accumulation of data in established twin cohorts. We started a new research project to analyze systematically (1) the variation of heritability estimates of height, BMI and their trajectories over the life course between birth cohorts, ethnicities and countries, and (2) to study the effects of birth-related factors, education and smoking on these anthropometric traits and whether these effects vary between twin cohorts. We identified 67 twin projects, including both monozygotic (MZ) and dizygotic (DZ) twins, using various sources. We asked for individual level data on height and weight including repeated measurements, birth related traits, background variables, education and smoking. By the end of 2014, 48 projects participated. Together, we have 893,458 height and weight measures (52% females) from 434,723 twin individuals, including 201,192 complete twin pairs (40% monozygotic, 40% same-sex dizygotic and 20% opposite-sex dizygotic) representing 22 countries. This project demonstrates that large-scale international twin studies are feasible and can promote the use of existing data for novel research purposes.

AB - For over 100 years, the genetics of human anthropometric traits has attracted scientific interest. In particular, height and body mass index (BMI, calculated as kg/m2) have been under intensive genetic research. However, it is still largely unknown whether and how heritability estimates vary between human populations. Opportunities to address this question have increased recently because of the establishment of many new twin cohorts and the increasing accumulation of data in established twin cohorts. We started a new research project to analyze systematically (1) the variation of heritability estimates of height, BMI and their trajectories over the life course between birth cohorts, ethnicities and countries, and (2) to study the effects of birth-related factors, education and smoking on these anthropometric traits and whether these effects vary between twin cohorts. We identified 67 twin projects, including both monozygotic (MZ) and dizygotic (DZ) twins, using various sources. We asked for individual level data on height and weight including repeated measurements, birth related traits, background variables, education and smoking. By the end of 2014, 48 projects participated. Together, we have 893,458 height and weight measures (52% females) from 434,723 twin individuals, including 201,192 complete twin pairs (40% monozygotic, 40% same-sex dizygotic and 20% opposite-sex dizygotic) representing 22 countries. This project demonstrates that large-scale international twin studies are feasible and can promote the use of existing data for novel research purposes.

KW - Anthropometry

KW - Body Height

KW - Body Mass Index

KW - Body Weight

KW - Female

KW - Gene-Environment Interaction

KW - Humans

KW - Male

KW - Phenotype

KW - Twin Studies as Topic

KW - Twins

U2 - 10.1017/thg.2015.29

DO - 10.1017/thg.2015.29

M3 - Journal article

C2 - 26014041

VL - 18

SP - 348

EP - 360

JO - Acta Geneticae Medicae et Gemellologiae

JF - Acta Geneticae Medicae et Gemellologiae

SN - 1832-4274

IS - 4

ER -