Vitamin D Concentrations at Birth and the Risk of Rheumatoid Arthritis in Early Adulthood: A Danish Population-Based Case-Cohort Study
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Vitamin D Concentrations at Birth and the Risk of Rheumatoid Arthritis in Early Adulthood : A Danish Population-Based Case-Cohort Study. / Cardoso, Isabel; Specht, Ina Olmer; Thorsteinsdottir, Fanney; Thorbek, Marta Jadwiga; Keller, Amélie; Stougaard, Maria; Cohen, Arieh S.; Händel, Mina Nicole; Kristensen, Lars Erik; Heitmann, Berit Lilienthal.
In: Nutrients, Vol. 14, No. 3, 447, 2022.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Vitamin D Concentrations at Birth and the Risk of Rheumatoid Arthritis in Early Adulthood
T2 - A Danish Population-Based Case-Cohort Study
AU - Cardoso, Isabel
AU - Specht, Ina Olmer
AU - Thorsteinsdottir, Fanney
AU - Thorbek, Marta Jadwiga
AU - Keller, Amélie
AU - Stougaard, Maria
AU - Cohen, Arieh S.
AU - Händel, Mina Nicole
AU - Kristensen, Lars Erik
AU - Heitmann, Berit Lilienthal
N1 - Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2022
Y1 - 2022
N2 - Background: Low vitamin D in pregnancy may impair the development of the fetal immune system and influence the risk of later development of rheumatoid arthritis (RA) in the offspring. The aim was to examine whether lower 25-hydroxyvitamin D3 (25(OH)D) concentrations at birth were associated with the risk of developing RA in early adulthood. Methods: This case-cohort study obtained data from Danish registers and biobanks. Cases included all individuals born during 1981–1996 and recorded in the Danish National Patient Register with a diagnosis of RA with age >18 years at first admission. The random comparison consisted of a subset of Danish children. Vitamin D concentrations were measured in newborn dried blood. In total, 805 RA cases and 2416 individuals from the subcohort were included in the final analysis. Weighted Cox regression was used to calculate hazard ratio (HR). Results: The median (interquartile rage (IQR)) 25(OH)D concentrations among cases were 24.9 nmol/L (IQR:15.4;36.9) and 23.9 nmol/L (IQR:13.6;36.4) among the subcohort. There was no indication of a lower risk of RA among individuals in the highest vitamin D quintile compared with the lowest (HRadj.:1.21 (0.90;1.63)). Conclusion: The risk of RA in early adulthood was not associated with vitamin D concentrations at birth.
AB - Background: Low vitamin D in pregnancy may impair the development of the fetal immune system and influence the risk of later development of rheumatoid arthritis (RA) in the offspring. The aim was to examine whether lower 25-hydroxyvitamin D3 (25(OH)D) concentrations at birth were associated with the risk of developing RA in early adulthood. Methods: This case-cohort study obtained data from Danish registers and biobanks. Cases included all individuals born during 1981–1996 and recorded in the Danish National Patient Register with a diagnosis of RA with age >18 years at first admission. The random comparison consisted of a subset of Danish children. Vitamin D concentrations were measured in newborn dried blood. In total, 805 RA cases and 2416 individuals from the subcohort were included in the final analysis. Weighted Cox regression was used to calculate hazard ratio (HR). Results: The median (interquartile rage (IQR)) 25(OH)D concentrations among cases were 24.9 nmol/L (IQR:15.4;36.9) and 23.9 nmol/L (IQR:13.6;36.4) among the subcohort. There was no indication of a lower risk of RA among individuals in the highest vitamin D quintile compared with the lowest (HRadj.:1.21 (0.90;1.63)). Conclusion: The risk of RA in early adulthood was not associated with vitamin D concentrations at birth.
KW - Cohort
KW - Denmark
KW - Dried blood spots
KW - Early adulthood
KW - Rheumatoid arthritis
KW - Vitamin D
U2 - 10.3390/nu14030447
DO - 10.3390/nu14030447
M3 - Journal article
C2 - 35276806
AN - SCOPUS:85122915242
VL - 14
JO - Nutrients
JF - Nutrients
SN - 2072-6643
IS - 3
M1 - 447
ER -
ID: 291113552