Marta Guasch Ferre

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Primary fields of research

My research focuses on investigating the role of dietary and lifestyle factors in chronic diseases, specifically, cardiovascular disease (CVD) and type 2 diabetes (T2D). I have incorporated high-throughput –omics techniques, metabolomics, and genetics, into traditional epidemiological analysis to gain insights into underlying mechanisms that could explain the associations between diet and lifestyle factors in relation to CVD and T2D.

My research group is dedicated to integrating nutrition and lifestyle with big data to advance the prevention of non-communicable diseases such as CVD and T2D.

I am also a Group Leader at Novo Nordisk Foundation Center for Basic Metabolic Research and Adjunct Associate Professor at the Department of Nutrition at Harvard T.H. Chan School of Public Health, United States.

 

LINK TO: Nutrition, -omics, and cardiometabolic diseases group

https://cbmr.ku.dk/research/human-genomics-and-metagenomics-in-metabolism/guasch-group/

Current research

• Nutritional Epidemiology - Diet for the prevention of cardiometabolic diseases: Evaluating the association between several dietary factors, dietary patterns, and chronic diseases in the context of large prospective cohort studies.
• The interplay between diet, metabolomics, and cardiometabolic diseases: Co-Investigator of international, multi-institutional collaborative NIH (National Institutes of Health, US) funded projects in the context of Mediterranean diet, plasma metabolites, and cardiometabolic diseases.
• Circulating metabolites, lifestyle factors, and mortality risk: PI of an NIH-funded grant which leverages unique resources with longitudinal data to identify metabolite profiles and networks associated with total mortality, longevity, and healthy aging.
• Leveraging big data to improve diet biomarkers: Leveraging large cohort studies and clinical trials with dietary data and metabolomics to advance in the field of improving objective dietary biomarkers through metabolomics.
• The intersection between nutrition, environmental determinants, and their impact on both human and planetary health. Co-Investigator of a project aimed at developing a planetary healthy diet score (PHD) based on the EAT-Lancet recommendations to identify dietary patterns healthy for humans and the planet and their associations with chronic diseases.

Teaching

Supervisor for bachelor students, master students, and PhD students.

Fields of interest

Nutrition, epidemiology, type 2 diabetes, cardiovascular disease, metabolomics

Selected publications

1. Metabolomics and Type 2 Diabetes Risk: An Updated Systematic Review and Meta-analysis of Prospective Cohort Studies

   Morze, J., Wittenbecher, C., Schwingshackl, L., Danielewicz, A., Rynkiewicz, A., Hu, F. B. & Guasch Ferre, Marta, 2022, In: Diabetes Care. p. 1013–1024 12 p.

   Research output: Contribution to journal › Journal article › Research › peer-review

2. Consumption of Total Olive Oil and Risk of Total and Cause-Specific Mortality in US Adults

   Guasch Ferre, Marta, Li, Y., Willett, W., Sun, Q., Sampson, L., Salas-Salvado, J., Martinez-Gonzalez, M., Stampfer, M. & Hu, F., 2021, In: Current Developments in Nutrition. 5, Supplement 2, 1 p.

   Research output: Contribution to journal › Journal article › Research › peer-review

3. Published

   Role of sociodemographic, clinical, behavioral, and molecular factors in precision prevention of type 2 diabetes: a systematic review

   Bodhini, D., Morton, R. W., Santhakumar, V., Nakabuye, Mariam, Pomares-Millan, H., Clemmensen, Christoffer, Fitzpatrick, S. L., Guasch Ferre, Marta, Pankow, J. S., Ried-Larsen, M., Franks, P. W., Tobias, D. K., Merino, Jordi, Mohan, V., Loos, Ruth & ADA/EASD Precision Medicine in Diabetes Initiative, A. P. M. I. D. I., 2023, medRxiv.

   Research output: Working paper › Preprint › Research

4. Polygenic scores, diet quality, and type 2 diabetes risk: An observational study among 35,759 adults from 3 US cohorts

   Merino, Jordi, Guasch Ferre, Marta, Li, J., Chung, W., Hu, Y., Ma, B., Li, Y., Kang, J. H., Kraft, P., Liang, L., Sun, Q., Franks, P. W., Manson, J. E., Willet, W. C., Florez, J. C. & Hu, F. B., 2022, In: PLoS Medicine. 19, 4, 20 p.

   Research output: Contribution to journal › Journal article › Research › peer-review