Epidemiological Seminar & Drinks. Monday May 2nd, seminar at 3 to 4 pm followed by drinks.

The trial and tribulations from the 26 years of the Diabetes Prevention Program and its Outcomes Study

Dr. Ella Temprosa, Department and Biostatistics and Bioinformatics, Biostatistics Center, the George Washington University

The Diabetes Prevention Program is a US based multicenter trial conducted from 1996 to 2001 that established the success of either an intensive lifestyle program or treatment with metformin to prevent or delay the development of type 2 diabetes (T2D) in individuals who were considered at high risk for developing the disease. The DPP demonstrated that lifestyle intervention, aimed at achieving weight loss, and metformin treatment reduced the risk of T2D development by 58% and 31%, respectively, compared to placebo, after an average of 3 years. This talk will review the trial and the impact on global diabetes prevention efforts and will discuss tribulations with regards to the design, methods, and statistical issues due to the changing medical and research landscape.

Dr. Ella Temprosa is an Associate Research Professor at the Department of Biostatistics and Bioinformatics. Her research projects have focused on Phase 3 NIH-sponsored multi-center clinical trials for more than 25 years at the Biostatistics Center, a research center at the George Washington University. She is the Principal Investigator of the Biostatistics Research and Coordinating Center for the NIDDK-sponsored landmark study, Diabetes Prevention Program, and its Outcome Study since 2013 and as biostatistician/ investigator since 1998. Her research interests include various aspects of clinical trial design, conduct and analyses as well as data visualization, longitudinal data analysis and missingness. Throughout her research career, she continues to enjoy the confluence of the technical, scientific, and public health aspects of collaborative studies in the areas of diabetes, cardiovascular disease, cancer, and obesity with major focus on novel markers such as adipocytes, cytokines, lipid subfractions, inflammation, endothelial dysfunction and more recently metabolomics. More recently, she is leading the data management efforts in the DC HIV cohort where she hopes to make the use of EHR data streams more robust for monitoring and analyses in order to explore the intersection of HIV and diabetes.
Everyone is invited to join us for a glass of wine and epidemiological networking after the seminar.
Participation is free and open to everyone. The seminar is arranged by the Section of Epidemiology and the Graduate Program in Public Health and Epidemiology.