1,2,3-triazolyl amino acids as AMPA receptor ligands

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The central nervous system glutamate receptors are an important target for drug discovery. Herein we report initial investigations into the synthesis and glutamate receptor activity of 1,2,3-triazolyl amino acids. Two compounds were found to be selective AMPA receptor ligands, which warrant further investigation.
Original languageEnglish
JournalBioorganic & Medicinal Chemistry Letters
Issue number24
Pages (from-to)7512-7515
Publication statusPublished - 15 Dec 2010

Bibliographical note

Keywords: synthesis; glutamate receptor; triazole

ID: 32132476