A follow-up from a randomized controlled trial suggests that fish oil in pregnancy may increase the risk of obesity and metabolic syndrome in the offspring-a reason for concern?
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A follow-up from a randomized controlled trial suggests that fish oil in pregnancy may increase the risk of obesity and metabolic syndrome in the offspring-a reason for concern? / Olsen, Sjurdur Frodi.
In: The American Journal of Clinical Nutrition, Vol. 119, No. 4, 2024, p. 863-864.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - A follow-up from a randomized controlled trial suggests that fish oil in pregnancy may increase the risk of obesity and metabolic syndrome in the offspring-a reason for concern?
AU - Olsen, Sjurdur Frodi
PY - 2024
Y1 - 2024
N2 - Vinding, Stokholm, Chaves, Bønnelykke and others, in the present issue of the American Journal of Clinical Nutrition, report potentially harmful offspring effects of taking supplements with long chain n-3 fatty acids, also known as n-3 polyunsaturated fatty acids (LCPUFAs) in pregnancy [1]. They examined the impact of maternal supplementation with fish oil during gestation, starting in week 24, on offspring growth and metabolic health assessed when the children were 10 y old. The study was based on follow-up from an influential trial in the field, the COPSAC2010 Study, which in 2016 provided evidence that fish oil could reduce offspring risk of persistent wheeze or asthma and infections of the lower respiratory tract, assessed up to age 5 y [2]. A number of additional studies focusing on a range of different outcomes in children have since been published based on this very same trial population. In the present work, the authors undertook physical examinations of the children at 10 y of age [1]. This publication succeeds 2 earlier publications from the trial cohort, where related outcomes were studied, one reporting increased birth weight for gestational age after maternal supplementation with n-3 LCPUFA, and the other reporting increased BMI during ages 1 to 6 y (several assessments were undertaken of BMI during this age span), as well as increased lean mass, bone mass, and fat mass (assessed by dual x-ray absorptiometry scan) at 6 y. Based on this new analysis, the authors infer that children of mothers receiving long chain n-3 fatty acids in pregnancy seem to have increased BMI, increased risk of being overweight, a tendency of increased fat percentage, and higher metabolic syndrome score at the age of 10
AB - Vinding, Stokholm, Chaves, Bønnelykke and others, in the present issue of the American Journal of Clinical Nutrition, report potentially harmful offspring effects of taking supplements with long chain n-3 fatty acids, also known as n-3 polyunsaturated fatty acids (LCPUFAs) in pregnancy [1]. They examined the impact of maternal supplementation with fish oil during gestation, starting in week 24, on offspring growth and metabolic health assessed when the children were 10 y old. The study was based on follow-up from an influential trial in the field, the COPSAC2010 Study, which in 2016 provided evidence that fish oil could reduce offspring risk of persistent wheeze or asthma and infections of the lower respiratory tract, assessed up to age 5 y [2]. A number of additional studies focusing on a range of different outcomes in children have since been published based on this very same trial population. In the present work, the authors undertook physical examinations of the children at 10 y of age [1]. This publication succeeds 2 earlier publications from the trial cohort, where related outcomes were studied, one reporting increased birth weight for gestational age after maternal supplementation with n-3 LCPUFA, and the other reporting increased BMI during ages 1 to 6 y (several assessments were undertaken of BMI during this age span), as well as increased lean mass, bone mass, and fat mass (assessed by dual x-ray absorptiometry scan) at 6 y. Based on this new analysis, the authors infer that children of mothers receiving long chain n-3 fatty acids in pregnancy seem to have increased BMI, increased risk of being overweight, a tendency of increased fat percentage, and higher metabolic syndrome score at the age of 10
KW - Pregnancy
KW - Female
KW - Humans
KW - Fish Oils
KW - Metabolic Syndrome/etiology
KW - Follow-Up Studies
KW - Obesity
KW - Fatty Acids, Omega-3/metabolism
KW - Dietary Supplements
U2 - 10.1016/j.ajcnut.2024.01.015
DO - 10.1016/j.ajcnut.2024.01.015
M3 - Journal article
C2 - 38569781
VL - 119
SP - 863
EP - 864
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
SN - 0002-9165
IS - 4
ER -
ID: 387933206