Abdominal Wall Defects in Greenland 1989–2015

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Abdominal Wall Defects in Greenland 1989–2015. / Bugge, Merete; Drachmann, Gitte; Kern, Peder; Budtz–Jørgensen, Esben; Eiberg, Hans; Olsen, Britta; Tommerup, Niels; Nielsen, Inge Merete.

In: Birth Defects Research. Part A: Clinical and Molecular Teratology, Vol. 109, No. 11, 2017, p. 836-842.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Bugge, M, Drachmann, G, Kern, P, Budtz–Jørgensen, E, Eiberg, H, Olsen, B, Tommerup, N & Nielsen, IM 2017, 'Abdominal Wall Defects in Greenland 1989–2015', Birth Defects Research. Part A: Clinical and Molecular Teratology, vol. 109, no. 11, pp. 836-842. https://doi.org/10.1002/bdr2.1025

APA

Bugge, M., Drachmann, G., Kern, P., Budtz–Jørgensen, E., Eiberg, H., Olsen, B., Tommerup, N., & Nielsen, I. M. (2017). Abdominal Wall Defects in Greenland 1989–2015. Birth Defects Research. Part A: Clinical and Molecular Teratology, 109(11), 836-842. https://doi.org/10.1002/bdr2.1025

Vancouver

Bugge M, Drachmann G, Kern P, Budtz–Jørgensen E, Eiberg H, Olsen B et al. Abdominal Wall Defects in Greenland 1989–2015. Birth Defects Research. Part A: Clinical and Molecular Teratology. 2017;109(11):836-842. https://doi.org/10.1002/bdr2.1025

Author

Bugge, Merete ; Drachmann, Gitte ; Kern, Peder ; Budtz–Jørgensen, Esben ; Eiberg, Hans ; Olsen, Britta ; Tommerup, Niels ; Nielsen, Inge Merete. / Abdominal Wall Defects in Greenland 1989–2015. In: Birth Defects Research. Part A: Clinical and Molecular Teratology. 2017 ; Vol. 109, No. 11. pp. 836-842.

Bibtex

@article{5812f3d1cb0246fea3b34bc0c1beceff,
title = "Abdominal Wall Defects in Greenland 1989–2015",
abstract = "Background: In the last decades, an increasing rate of gastroschisis but not of omphalocele has been reported worldwide. Greenland is the world's largest island, but 80% is covered by an ice cap, it has a small population of around 56,000 peoples (as of 2016). The occurrence of abdominal wall defects has never been investigated in Greenland. Methods: The present study is based on data retrieved from three nationwide and two local registries in the Greenlandic health care system over 27 years (1989–2015). Results: We identified 33 infants with abdominal wall defects born in the study time period. All cases were reclassified to 28 cases of gastroschisis, four cases of omphalocele, and there was 1 infant in the indeterminate group. The point prevalence at birth for gastroschisis increased significantly from 8 to 35 (average 10.7) per 10,000 liveborn and -stillborn infants. Mothers below 20 years of age represented 23% of all cases and the prevalence for this group was 17 per 10,000 liveborn and stillborn. Perinatal mortality for infants with gastroschisis was high (18%), and 1 year survival was 71%. For omphalocele, the prevalence varied from 8 to 11 per 10,000 liveborn and stillborn infants. There was no increasing rate in the period, further highlighting an etiological difference between gastroschisis and omphalocele. Conclusion: This study confirms the increasing prevalence of gastroschisis in Greenland in the period from 1989 to 2015. The average was 10.7 per 10,000 liveborn and -stillborn infants and, to the best of our knowledge, this is the highest prevalence ever reported. Birth Defects Research 109:836–842, 2017.",
keywords = "abdominal wall defects, gastroschisis, Greenland, omphalocele",
author = "Merete Bugge and Gitte Drachmann and Peder Kern and Esben Budtz–J{\o}rgensen and Hans Eiberg and Britta Olsen and Niels Tommerup and Nielsen, {Inge Merete}",
year = "2017",
doi = "10.1002/bdr2.1025",
language = "English",
volume = "109",
pages = "836--842",
journal = "Birth Defects Research Part B - Developmental and Reproductive Toxicology",
issn = "1542-0752",
publisher = "Wiley",
number = "11",

}

RIS

TY - JOUR

T1 - Abdominal Wall Defects in Greenland 1989–2015

AU - Bugge, Merete

AU - Drachmann, Gitte

AU - Kern, Peder

AU - Budtz–Jørgensen, Esben

AU - Eiberg, Hans

AU - Olsen, Britta

AU - Tommerup, Niels

AU - Nielsen, Inge Merete

PY - 2017

Y1 - 2017

N2 - Background: In the last decades, an increasing rate of gastroschisis but not of omphalocele has been reported worldwide. Greenland is the world's largest island, but 80% is covered by an ice cap, it has a small population of around 56,000 peoples (as of 2016). The occurrence of abdominal wall defects has never been investigated in Greenland. Methods: The present study is based on data retrieved from three nationwide and two local registries in the Greenlandic health care system over 27 years (1989–2015). Results: We identified 33 infants with abdominal wall defects born in the study time period. All cases were reclassified to 28 cases of gastroschisis, four cases of omphalocele, and there was 1 infant in the indeterminate group. The point prevalence at birth for gastroschisis increased significantly from 8 to 35 (average 10.7) per 10,000 liveborn and -stillborn infants. Mothers below 20 years of age represented 23% of all cases and the prevalence for this group was 17 per 10,000 liveborn and stillborn. Perinatal mortality for infants with gastroschisis was high (18%), and 1 year survival was 71%. For omphalocele, the prevalence varied from 8 to 11 per 10,000 liveborn and stillborn infants. There was no increasing rate in the period, further highlighting an etiological difference between gastroschisis and omphalocele. Conclusion: This study confirms the increasing prevalence of gastroschisis in Greenland in the period from 1989 to 2015. The average was 10.7 per 10,000 liveborn and -stillborn infants and, to the best of our knowledge, this is the highest prevalence ever reported. Birth Defects Research 109:836–842, 2017.

AB - Background: In the last decades, an increasing rate of gastroschisis but not of omphalocele has been reported worldwide. Greenland is the world's largest island, but 80% is covered by an ice cap, it has a small population of around 56,000 peoples (as of 2016). The occurrence of abdominal wall defects has never been investigated in Greenland. Methods: The present study is based on data retrieved from three nationwide and two local registries in the Greenlandic health care system over 27 years (1989–2015). Results: We identified 33 infants with abdominal wall defects born in the study time period. All cases were reclassified to 28 cases of gastroschisis, four cases of omphalocele, and there was 1 infant in the indeterminate group. The point prevalence at birth for gastroschisis increased significantly from 8 to 35 (average 10.7) per 10,000 liveborn and -stillborn infants. Mothers below 20 years of age represented 23% of all cases and the prevalence for this group was 17 per 10,000 liveborn and stillborn. Perinatal mortality for infants with gastroschisis was high (18%), and 1 year survival was 71%. For omphalocele, the prevalence varied from 8 to 11 per 10,000 liveborn and stillborn infants. There was no increasing rate in the period, further highlighting an etiological difference between gastroschisis and omphalocele. Conclusion: This study confirms the increasing prevalence of gastroschisis in Greenland in the period from 1989 to 2015. The average was 10.7 per 10,000 liveborn and -stillborn infants and, to the best of our knowledge, this is the highest prevalence ever reported. Birth Defects Research 109:836–842, 2017.

KW - abdominal wall defects

KW - gastroschisis

KW - Greenland

KW - omphalocele

U2 - 10.1002/bdr2.1025

DO - 10.1002/bdr2.1025

M3 - Journal article

C2 - 28464537

AN - SCOPUS:85025822543

VL - 109

SP - 836

EP - 842

JO - Birth Defects Research Part B - Developmental and Reproductive Toxicology

JF - Birth Defects Research Part B - Developmental and Reproductive Toxicology

SN - 1542-0752

IS - 11

ER -

ID: 183580640