Accumulation of Major Life Events in Childhood and Adult Life and Risk of Type 2 Diabetes Mellitus

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Accumulation of Major Life Events in Childhood and Adult Life and Risk of Type 2 Diabetes Mellitus. / Pedersen, Jolene Lee Masters; Rod, Naja Hulvej; Andersen, Ingelise; Lange, Theis; Poulsen, Gry; Prescott, Eva; Lund, Rikke.

In: P L o S One, Vol. 10, No. 9, 0138654, 22.09.2015, p. 1-12.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Pedersen, JLM, Rod, NH, Andersen, I, Lange, T, Poulsen, G, Prescott, E & Lund, R 2015, 'Accumulation of Major Life Events in Childhood and Adult Life and Risk of Type 2 Diabetes Mellitus', P L o S One, vol. 10, no. 9, 0138654, pp. 1-12. https://doi.org/10.1371/journal.pone.0138654

APA

Pedersen, J. L. M., Rod, N. H., Andersen, I., Lange, T., Poulsen, G., Prescott, E., & Lund, R. (2015). Accumulation of Major Life Events in Childhood and Adult Life and Risk of Type 2 Diabetes Mellitus. P L o S One, 10(9), 1-12. [0138654]. https://doi.org/10.1371/journal.pone.0138654

Vancouver

Pedersen JLM, Rod NH, Andersen I, Lange T, Poulsen G, Prescott E et al. Accumulation of Major Life Events in Childhood and Adult Life and Risk of Type 2 Diabetes Mellitus. P L o S One. 2015 Sep 22;10(9):1-12. 0138654. https://doi.org/10.1371/journal.pone.0138654

Author

Pedersen, Jolene Lee Masters ; Rod, Naja Hulvej ; Andersen, Ingelise ; Lange, Theis ; Poulsen, Gry ; Prescott, Eva ; Lund, Rikke. / Accumulation of Major Life Events in Childhood and Adult Life and Risk of Type 2 Diabetes Mellitus. In: P L o S One. 2015 ; Vol. 10, No. 9. pp. 1-12.

Bibtex

@article{62c5c3c9968a4a979644a2984973a10d,
title = "Accumulation of Major Life Events in Childhood and Adult Life and Risk of Type 2 Diabetes Mellitus",
abstract = "Background: The aim of the study was to estimate the effect of the accumulation of major life events(MLE) in childhood and adulthood, in both the private and working domains, on risk of type2 diabetes mellitus (T2DM). Furthermore, we aimed to test the possible interaction betweenchildhood and adult MLE and to investigate modification of these associations by educational attainment.Methods: The study was based on 4,761 participants from the Copenhagen City Heart Study free ofdiabetes at baseline and followed for 10 years. MLE were categorized as 0, 1, 2, 3 or moreevents. Multivariate logistic regression models adjusted for age, sex, education and familyhistory of diabetes were used to estimate the association between MLE and T2DM.Results: In childhood, experiencing 3 or more MLE was associated with a 69{\%} higher risk of developingT2DM (Odds Ratio (OR) 1.69; 95{\%} Confidence Interval (CI) 1.60, 3.27). The accumulationof MLE in adult private (p-trend = 0.016) and work life (p-trend = 0.049) was associatedwith risk of T2DM in a dose response manner. There was no evidence that experiencingMLE in both childhood and adult life was more strongly associated with T2DM thanexperiencing events at only one time point. There was some evidence that being simultaneouslyexposed to childhood MLE and short education (OR 2.28; 95{\%} C.I. 1.45, 3.59) andwork MLE and short education (OR 2.86; 95{\%} C.I. 1.62, 5.03) was associated with higherrisk of T2DM, as the joint effects were greater than the sum of their individual effects.Conclusions: Findings from this study suggest that the accumulation of MLE in childhood, private adultlife and work life, respectively, are risk factors for developing T2DM.",
author = "Pedersen, {Jolene Lee Masters} and Rod, {Naja Hulvej} and Ingelise Andersen and Theis Lange and Gry Poulsen and Eva Prescott and Rikke Lund",
year = "2015",
month = "9",
day = "22",
doi = "10.1371/journal.pone.0138654",
language = "English",
volume = "10",
pages = "1--12",
journal = "P L o S One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "9",

}

RIS

TY - JOUR

T1 - Accumulation of Major Life Events in Childhood and Adult Life and Risk of Type 2 Diabetes Mellitus

AU - Pedersen, Jolene Lee Masters

AU - Rod, Naja Hulvej

AU - Andersen, Ingelise

AU - Lange, Theis

AU - Poulsen, Gry

AU - Prescott, Eva

AU - Lund, Rikke

PY - 2015/9/22

Y1 - 2015/9/22

N2 - Background: The aim of the study was to estimate the effect of the accumulation of major life events(MLE) in childhood and adulthood, in both the private and working domains, on risk of type2 diabetes mellitus (T2DM). Furthermore, we aimed to test the possible interaction betweenchildhood and adult MLE and to investigate modification of these associations by educational attainment.Methods: The study was based on 4,761 participants from the Copenhagen City Heart Study free ofdiabetes at baseline and followed for 10 years. MLE were categorized as 0, 1, 2, 3 or moreevents. Multivariate logistic regression models adjusted for age, sex, education and familyhistory of diabetes were used to estimate the association between MLE and T2DM.Results: In childhood, experiencing 3 or more MLE was associated with a 69% higher risk of developingT2DM (Odds Ratio (OR) 1.69; 95% Confidence Interval (CI) 1.60, 3.27). The accumulationof MLE in adult private (p-trend = 0.016) and work life (p-trend = 0.049) was associatedwith risk of T2DM in a dose response manner. There was no evidence that experiencingMLE in both childhood and adult life was more strongly associated with T2DM thanexperiencing events at only one time point. There was some evidence that being simultaneouslyexposed to childhood MLE and short education (OR 2.28; 95% C.I. 1.45, 3.59) andwork MLE and short education (OR 2.86; 95% C.I. 1.62, 5.03) was associated with higherrisk of T2DM, as the joint effects were greater than the sum of their individual effects.Conclusions: Findings from this study suggest that the accumulation of MLE in childhood, private adultlife and work life, respectively, are risk factors for developing T2DM.

AB - Background: The aim of the study was to estimate the effect of the accumulation of major life events(MLE) in childhood and adulthood, in both the private and working domains, on risk of type2 diabetes mellitus (T2DM). Furthermore, we aimed to test the possible interaction betweenchildhood and adult MLE and to investigate modification of these associations by educational attainment.Methods: The study was based on 4,761 participants from the Copenhagen City Heart Study free ofdiabetes at baseline and followed for 10 years. MLE were categorized as 0, 1, 2, 3 or moreevents. Multivariate logistic regression models adjusted for age, sex, education and familyhistory of diabetes were used to estimate the association between MLE and T2DM.Results: In childhood, experiencing 3 or more MLE was associated with a 69% higher risk of developingT2DM (Odds Ratio (OR) 1.69; 95% Confidence Interval (CI) 1.60, 3.27). The accumulationof MLE in adult private (p-trend = 0.016) and work life (p-trend = 0.049) was associatedwith risk of T2DM in a dose response manner. There was no evidence that experiencingMLE in both childhood and adult life was more strongly associated with T2DM thanexperiencing events at only one time point. There was some evidence that being simultaneouslyexposed to childhood MLE and short education (OR 2.28; 95% C.I. 1.45, 3.59) andwork MLE and short education (OR 2.86; 95% C.I. 1.62, 5.03) was associated with higherrisk of T2DM, as the joint effects were greater than the sum of their individual effects.Conclusions: Findings from this study suggest that the accumulation of MLE in childhood, private adultlife and work life, respectively, are risk factors for developing T2DM.

U2 - 10.1371/journal.pone.0138654

DO - 10.1371/journal.pone.0138654

M3 - Journal article

C2 - 26394040

VL - 10

SP - 1

EP - 12

JO - P L o S One

JF - P L o S One

SN - 1932-6203

IS - 9

M1 - 0138654

ER -

ID: 153043859