Accumulation of Major Life Events in Childhood and Adult Life and Risk of Type 2 Diabetes Mellitus
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Accumulation of Major Life Events in Childhood and Adult Life and Risk of Type 2 Diabetes Mellitus. / Pedersen, Jolene Lee Masters; Rod, Naja Hulvej; Andersen, Ingelise; Lange, Theis; Poulsen, Gry; Prescott, Eva; Lund, Rikke.
In: P L o S One, Vol. 10, No. 9, 0138654, 22.09.2015, p. 1-12.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Accumulation of Major Life Events in Childhood and Adult Life and Risk of Type 2 Diabetes Mellitus
AU - Pedersen, Jolene Lee Masters
AU - Rod, Naja Hulvej
AU - Andersen, Ingelise
AU - Lange, Theis
AU - Poulsen, Gry
AU - Prescott, Eva
AU - Lund, Rikke
PY - 2015/9/22
Y1 - 2015/9/22
N2 - Background: The aim of the study was to estimate the effect of the accumulation of major life events(MLE) in childhood and adulthood, in both the private and working domains, on risk of type2 diabetes mellitus (T2DM). Furthermore, we aimed to test the possible interaction betweenchildhood and adult MLE and to investigate modification of these associations by educational attainment.Methods: The study was based on 4,761 participants from the Copenhagen City Heart Study free ofdiabetes at baseline and followed for 10 years. MLE were categorized as 0, 1, 2, 3 or moreevents. Multivariate logistic regression models adjusted for age, sex, education and familyhistory of diabetes were used to estimate the association between MLE and T2DM.Results: In childhood, experiencing 3 or more MLE was associated with a 69% higher risk of developingT2DM (Odds Ratio (OR) 1.69; 95% Confidence Interval (CI) 1.60, 3.27). The accumulationof MLE in adult private (p-trend = 0.016) and work life (p-trend = 0.049) was associatedwith risk of T2DM in a dose response manner. There was no evidence that experiencingMLE in both childhood and adult life was more strongly associated with T2DM thanexperiencing events at only one time point. There was some evidence that being simultaneouslyexposed to childhood MLE and short education (OR 2.28; 95% C.I. 1.45, 3.59) andwork MLE and short education (OR 2.86; 95% C.I. 1.62, 5.03) was associated with higherrisk of T2DM, as the joint effects were greater than the sum of their individual effects.Conclusions: Findings from this study suggest that the accumulation of MLE in childhood, private adultlife and work life, respectively, are risk factors for developing T2DM.
AB - Background: The aim of the study was to estimate the effect of the accumulation of major life events(MLE) in childhood and adulthood, in both the private and working domains, on risk of type2 diabetes mellitus (T2DM). Furthermore, we aimed to test the possible interaction betweenchildhood and adult MLE and to investigate modification of these associations by educational attainment.Methods: The study was based on 4,761 participants from the Copenhagen City Heart Study free ofdiabetes at baseline and followed for 10 years. MLE were categorized as 0, 1, 2, 3 or moreevents. Multivariate logistic regression models adjusted for age, sex, education and familyhistory of diabetes were used to estimate the association between MLE and T2DM.Results: In childhood, experiencing 3 or more MLE was associated with a 69% higher risk of developingT2DM (Odds Ratio (OR) 1.69; 95% Confidence Interval (CI) 1.60, 3.27). The accumulationof MLE in adult private (p-trend = 0.016) and work life (p-trend = 0.049) was associatedwith risk of T2DM in a dose response manner. There was no evidence that experiencingMLE in both childhood and adult life was more strongly associated with T2DM thanexperiencing events at only one time point. There was some evidence that being simultaneouslyexposed to childhood MLE and short education (OR 2.28; 95% C.I. 1.45, 3.59) andwork MLE and short education (OR 2.86; 95% C.I. 1.62, 5.03) was associated with higherrisk of T2DM, as the joint effects were greater than the sum of their individual effects.Conclusions: Findings from this study suggest that the accumulation of MLE in childhood, private adultlife and work life, respectively, are risk factors for developing T2DM.
U2 - 10.1371/journal.pone.0138654
DO - 10.1371/journal.pone.0138654
M3 - Journal article
C2 - 26394040
VL - 10
SP - 1
EP - 12
JO - PLoS ONE
JF - PLoS ONE
SN - 1932-6203
IS - 9
M1 - 0138654
ER -
ID: 153043859