Additive interaction in survival analysis: use of the additive hazards model

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Additive interaction in survival analysis : use of the additive hazards model. / Rod, Naja Hulvej; Lange, Theis; Andersen, Ingelise; Marott, Jacob Louis; Diderichsen, Finn.

In: Epidemiology, Vol. 23, No. 5, 09.2012, p. 733-7.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Rod, NH, Lange, T, Andersen, I, Marott, JL & Diderichsen, F 2012, 'Additive interaction in survival analysis: use of the additive hazards model', Epidemiology, vol. 23, no. 5, pp. 733-7. https://doi.org/10.1097/EDE.0b013e31825fa218

APA

Rod, N. H., Lange, T., Andersen, I., Marott, J. L., & Diderichsen, F. (2012). Additive interaction in survival analysis: use of the additive hazards model. Epidemiology, 23(5), 733-7. https://doi.org/10.1097/EDE.0b013e31825fa218

Vancouver

Rod NH, Lange T, Andersen I, Marott JL, Diderichsen F. Additive interaction in survival analysis: use of the additive hazards model. Epidemiology. 2012 Sep;23(5):733-7. https://doi.org/10.1097/EDE.0b013e31825fa218

Author

Rod, Naja Hulvej ; Lange, Theis ; Andersen, Ingelise ; Marott, Jacob Louis ; Diderichsen, Finn. / Additive interaction in survival analysis : use of the additive hazards model. In: Epidemiology. 2012 ; Vol. 23, No. 5. pp. 733-7.

Bibtex

@article{e8805326abea46edb152d4547f76f8dd,
title = "Additive interaction in survival analysis: use of the additive hazards model",
abstract = "It is a widely held belief in public health and clinical decision-making that interventions or preventive strategies should be aimed at patients or population subgroups where most cases could potentially be prevented. To identify such subgroups, deviation from additivity of absolute effects is the relevant measure of interest. Multiplicative survival models, such as the Cox proportional hazards model, are often used to estimate the association between exposure and risk of disease in prospective studies. In Cox models, deviations from additivity have usually been assessed by surrogate measures of additive interaction derived from multiplicative models-an approach that is both counter-intuitive and sometimes invalid. This paper presents a straightforward and intuitive way of assessing deviation from additivity of effects in survival analysis by use of the additive hazards model. The model directly estimates the absolute size of the deviation from additivity and provides confidence intervals. In addition, the model can accommodate both continuous and categorical exposures and models both exposures and potential confounders on the same underlying scale. To illustrate the approach, we present an empirical example of interaction between education and smoking on risk of lung cancer. We argue that deviations from additivity of effects are important for public health interventions and clinical decision-making, and such estimations should be encouraged in prospective studies on health. A detailed implementation guide of the additive hazards model is provided in the appendix.",
author = "Rod, {Naja Hulvej} and Theis Lange and Ingelise Andersen and Marott, {Jacob Louis} and Finn Diderichsen",
year = "2012",
month = "9",
doi = "10.1097/EDE.0b013e31825fa218",
language = "English",
volume = "23",
pages = "733--7",
journal = "Epidemiology",
issn = "1044-3983",
publisher = "Lippincott Williams & Wilkins",
number = "5",

}

RIS

TY - JOUR

T1 - Additive interaction in survival analysis

T2 - use of the additive hazards model

AU - Rod, Naja Hulvej

AU - Lange, Theis

AU - Andersen, Ingelise

AU - Marott, Jacob Louis

AU - Diderichsen, Finn

PY - 2012/9

Y1 - 2012/9

N2 - It is a widely held belief in public health and clinical decision-making that interventions or preventive strategies should be aimed at patients or population subgroups where most cases could potentially be prevented. To identify such subgroups, deviation from additivity of absolute effects is the relevant measure of interest. Multiplicative survival models, such as the Cox proportional hazards model, are often used to estimate the association between exposure and risk of disease in prospective studies. In Cox models, deviations from additivity have usually been assessed by surrogate measures of additive interaction derived from multiplicative models-an approach that is both counter-intuitive and sometimes invalid. This paper presents a straightforward and intuitive way of assessing deviation from additivity of effects in survival analysis by use of the additive hazards model. The model directly estimates the absolute size of the deviation from additivity and provides confidence intervals. In addition, the model can accommodate both continuous and categorical exposures and models both exposures and potential confounders on the same underlying scale. To illustrate the approach, we present an empirical example of interaction between education and smoking on risk of lung cancer. We argue that deviations from additivity of effects are important for public health interventions and clinical decision-making, and such estimations should be encouraged in prospective studies on health. A detailed implementation guide of the additive hazards model is provided in the appendix.

AB - It is a widely held belief in public health and clinical decision-making that interventions or preventive strategies should be aimed at patients or population subgroups where most cases could potentially be prevented. To identify such subgroups, deviation from additivity of absolute effects is the relevant measure of interest. Multiplicative survival models, such as the Cox proportional hazards model, are often used to estimate the association between exposure and risk of disease in prospective studies. In Cox models, deviations from additivity have usually been assessed by surrogate measures of additive interaction derived from multiplicative models-an approach that is both counter-intuitive and sometimes invalid. This paper presents a straightforward and intuitive way of assessing deviation from additivity of effects in survival analysis by use of the additive hazards model. The model directly estimates the absolute size of the deviation from additivity and provides confidence intervals. In addition, the model can accommodate both continuous and categorical exposures and models both exposures and potential confounders on the same underlying scale. To illustrate the approach, we present an empirical example of interaction between education and smoking on risk of lung cancer. We argue that deviations from additivity of effects are important for public health interventions and clinical decision-making, and such estimations should be encouraged in prospective studies on health. A detailed implementation guide of the additive hazards model is provided in the appendix.

U2 - 10.1097/EDE.0b013e31825fa218

DO - 10.1097/EDE.0b013e31825fa218

M3 - Journal article

C2 - 22732385

VL - 23

SP - 733

EP - 737

JO - Epidemiology

JF - Epidemiology

SN - 1044-3983

IS - 5

ER -

ID: 40343312