Adhesion of Plasmodium falciparum infected erythrocytes in ex vivo perfused placental tissue: a novel model of placental malaria
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- Adhesion of Plasmodium falciparum infected erythrocytes in ex vivo perfused placental tissue: a novel model of placental malaria
Final published version, 1.52 MB, PDF document
Caroline Pehrson, Line Mathiesen, Kristine K Heno, Ali Salanti, Mafalda dos Santos Marques Resende, Ron Dzikowski, Peter Damm, Stefan R Hansson, Christopher L King, Henning Schneider, Christian W Wang, Thomas Lavstsen, Thor G Theander, Lisbeth E Knudsen, Morten A Nielsen
RESULTS: The ex vivo placental perfusion model was modified to study adhesion of infected erythrocytes binding to CSA, endothelial protein C receptor (EPCR) or a transgenic parasite where P. falciparum erythrocyte membrane protein 1 expression had been shut down. Infected erythrocytes expressing VAR2CSA accumulated in perfused placental tissue whereas the EPCR binding and the transgenic parasite did not. Soluble CSA and antibodies specific against VAR2CSA inhibited binding of infected erythrocytes.
CONCLUSION: The ex vivo model provides a novel way of studying receptor-ligand interactions and antibody mediated inhibition of binding in placental malaria.
|Number of pages||12|
|Publication status||Published - 26 May 2016|
- Faculty of Health and Medical Sciences - Placental malaria, Placental perfusion, VAR2CSA
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